Physicochemical and Biological Performance of Aloe Vera-Incorporated Native Collagen Films

Andonegi, Mireia; Irastorza, Ainhoa; Izeta, Ander; Caba, Koro de la; Guerrero, Pedro

doi:10.3390/pharmaceutics12121173

Cited by 32 publications

(27 citation statements)

References 52 publications

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“…The broad band at around 3500–2500 cm −1 can be assigned to amide A (N-H stretching) and OH in collagen [ 38 , 39 ]. Distinctive bands for collagen are also visible at 1631 cm −1 for amide I, which indicates C=O stretching, at 1541 cm −1 for amide II (N-H binding), and 1233 cm −1 for amide III (C-N bending).…”

Section: Resultsmentioning

confidence: 99%

The Infuence of Salicin on Rheological and Film-Forming Properties of Collagen

2021

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Collagen films are widely used as adhesives in medicine and cosmetology. However, its properties require modification. In this work, the influence of salicin on the properties of collagen solution and films was studied. Collagen was extracted from silver carp skin. The rheological properties of collagen solutions with and without salicin were characterized by steady shear tests. Thin collagen films were prepared by solvent evaporation. The structure of films was researched using infrared spectroscopy. The surface properties of films were investigated using Atomic Force Microscopy (AFM). Mechanical properties were measured as well. It was found that the addition of salicin modified the roughness of collagen films and their mechanical and rheological properties. The above-mentioned parameters are very important in potential applications of collagen films containing salicin.

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Section: Resultsmentioning

confidence: 99%

The Infuence of Salicin on Rheological and Film-Forming Properties of Collagen

2021

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“…Native collagen was obtained according to the method of Andonegi et al [ 26 ]. Firstly, porcine skins were defatted by immersion into 1 M NaOH solution for 12 h and then, neutralized in phosphate buffer saline (PBS) solution (pH = 7.4).…”

Section: Methodsmentioning

confidence: 99%

3D-Printed Mucoadhesive Collagen Scaffolds as a Local Tetrahydrocurcumin Delivery System

et al. 2021

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Native collagen doughs were processed using a syringe-based extrusion 3D printer to obtain collagen scaffolds. Before processing, the rheological properties of the doughs were analyzed to determine the optimal 3D printing conditions. Samples showed a high shear-thinning behavior, reported beneficial in the 3D printing process. In addition, tetrahydrocurcumin (THC) was incorporated into the dough formulation and its effect on collagen structure, as well as the resulting scaffold’s suitability for wound healing applications, were assessed. The denaturation peak observed by differential scanning calorimetry (DSC), along with the images of the scaffolds’ surfaces assessed using scanning electron microscopy (SEM), showed that the fibrillar structure of collagen was maintained. These outcomes were correlated with X-ray diffraction (XRD) results, which showed an increase of the lateral packaging of collagen chains was observed in the samples with a THC content up to 4%, while a higher content of THC considerably decreased the structural order of collagen. Furthermore, physical interactions between collagen and THC molecules were observed using Fourier transform infrared (FTIR) spectroscopy. Additionally, all samples showed swelling and a controlled release of THC. These results along with the mucoadhesive properties of collagen suggested the potential of these THC–collagen scaffolds as sustained THC delivery systems.

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“…Fourier transform infrared spectroscopy was used to determine the functional group's presence in membrane Hypericum perforatum (HP) oil-loaded chitosan in the form of cryogel for healing wounds. [69] Cryogels are three-dimensional structures produced by cryotropic gelation; by changing the quantity of H. perforatum oil, the pore size distribution of the composite cryogels can be varied.…”

Section: Hypericum Perforatummentioning

confidence: 99%

“…Synergy, in this context, refers to the biochemical interactions between active ingredients in aloe vera and the body's coordinated reactions to these ingredients. [ 69 ] Aloe vera (AV) is a gel applied topically to treat lesions and has anti‐inflammatory, antibacterial, and antiseptic properties. Microorganisms can be used as antifungals to prevent post‐harvest fungal infections since they also limit the growth of Gram‐positive and Gram‐negative bacteria.…”

Section: Fabrication Of Biopolymer Wound Healing Materials Using Trad...mentioning

confidence: 99%

Bio‐based polymers containing traditional medicinal fillers for wound healing applications – An evaluation of neoteric development and future perspectives

Unni,

Gayathri

et al. 2023

Biotechnology Journal

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In recent years, health‐care providers have seen more patients with difficult‐to‐treat wounds and burns. The biopolymer‐based wound dressing protects the wounded area while assisting in the recovery of dermal and epithelial tissues throughout the healing process. The overall number of patients with chronic lesions has been expanding due to developing society, over weight, and cardiovascular illness. For the treatment of chronic wounds, there is an increasing demand for the development of ideal wound dressing materials with excellent properties such as antibacterial activity, biocompatibility, free radical scavenging capacity, non‐adherent property, hydrophilicity, and so on. Nevertheless, owing to the above mention properties, natural polymers are being used for several key functions of biomedicine like narcotic distribution systems, tissue manufacturing, bandages, and so on. Accordingly, the significance of these bio‐based polymers interfered with healing functions that lead to informing and inspiring youth and scientist researchers worldwide to grab with these far‐reaching areas of medicine and biology. The review highlights the physiochemical properties of natural polymers, the biological evaluation of various materials as wound dressings, their synthesis and mechanical properties, clinical status, challenges, and future perspectives.

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Physicochemical and Biological Performance of Aloe Vera-Incorporated Native Collagen Films

Cited by 32 publications

References 52 publications

The Infuence of Salicin on Rheological and Film-Forming Properties of Collagen

The Infuence of Salicin on Rheological and Film-Forming Properties of Collagen

3D-Printed Mucoadhesive Collagen Scaffolds as a Local Tetrahydrocurcumin Delivery System

Bio‐based polymers containing traditional medicinal fillers for wound healing applications – An evaluation of neoteric development and future perspectives

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