Physico-Chemical Study of Mn(II), Co(II), Cu(II), Cr(III), and Pd(II) Complexes with Schiff-Base and Aminopyrimidyl Derivatives and Anti-Cancer, Antioxidant, Antimicrobial Applications

Abstract

A new class of biologically active mineral complexes was synthesized by reacting the following metal salts: MnCl2·4H2O, CoCl2·6H2O, CuCl2·2H2O, CrCl3·6H2O, and PdCl2 respectively with 2-amino-4,6-dimethyl pyrimidine (ADMPY) and Schiff’s base resulting from the condensation reaction between benzaldehyde with p-phenylenediamine and 2-hydroxy-1-naphthaldehyde as ligands have been synthesized and characterized on the basis of their CHN, thermal analysis, XRD, SEM and magnetic measurements along with their FT-IR and UV-vis spectra. The scanning electron microscope SEM measurements and the calculations on the powder XRD data indicate the nano-sized nature of the prepared complexes (average size 32–88 nm). The spectral data confirmed the coordinated ligand (HL) via a nitrogen atom of an azomethine group (-C=N-) and phenolic -OH group and NH2-ADMPY ligand with the metal ions. An octahedral geometry for all complexes has been proposed based on magnetic and electronic spectral data except Pd(II) complex, which has a tetrahedral geometry. Molecular modeling was performed for Cu(II) complex using the density functional method DFT/B3LYP to study the structures and the frontier molecular orbitals (HOMO and LUMO). The antioxidant of the complexes was studied using the 2,2-diphenyl-1-picrylhydrazyl (DPPH)-free radical-scavenging assays. The metal complexes were tested in vitro for anticancer activities against two cancer lines A-549 and MRC-5 cells. Cu(II) and Pd(II) complexes showed the highest cytotoxicity effect, comparable to that of other cis-platinum-based drugs. The complexes showed significant activity against fungi and bacteria.

Novel Schiff Base Derived from Amino Pyrene: Synthesis, Characterization, Crystal Structure Determination, and Anticancer Applications of the Ligand and Its Metal Complexes

“…The magnetic moment value of 4.16 BM for the Co(II) complex is consistent with high-spin Co 2+ ions, which is in agreement with the reported value for tetrahedral geometry. The electronic spectrum for the Cr(III) complex band exhibited at 680 nm is assigned to the 4 A 2g → 4 T 2g (F) transition, as expected for octahedral complexes [28]. The magnetic moment value of 3.61 B.M.…”

Preparation and Characterization of Nano-Sized Co(II), Cu(II), Mn(II) and Ni(II) Coordination PAA/Alginate Biopolymers and Study of Their Biological and Anticancer Performance

“…In addition, at these wavenumber frequencies, the IR spectra of the complexes showed separation values ∆υ (representing the difference between ν (COO)asym and ν (COO)sym ) which are around 277-312 cm −1 , pointing to a monodentate mode of coordination for the carboxylate group in a network of hydrogen bonds [46]. The IR spectra of the polymeric complexes show a band at 409-471 cm −1 allocated to (M-Cl) [47]. The weak bands at 409-471 cm −1 in the far IR regions were observed for complexes and are attributed to chloride anions coordinated in a trans-octahedral geometry.…”

Antioxidant Activity and DFT Calculations of Metal Complexes Derived from a Schiff Base Ligand: Synthesis, Characterization, and Biological Evaluation

“…The observed findings are in line with literature studies exploring similar systems. For instance, Al-fakeh et al [52] investigated metal complexes derived from Schiff bases and reported enhanced radical scavenging activity upon coordination with Mn(II) ions, while limited effects were observed with Ni(II) and Cu(II) ions. This supports our observation that only coordination with Mn(II) influenced the activity of the ligand (C1).…”