Physico-chemical characterization of solid state reaction between terephtalaldehyde and p-aminophenol

Meltzer, Viorica; Oancea, Petruţa; Stănculescu, Ioana; Pincu, Elena

doi:10.33224/rrch.2021.66.3.07

Cited by 3 publications

(3 citation statements)

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“…FTIR spectroscopy is a useful tool in the investigation of molecular interactions appearing between the API components of physical mixtures [ 22 , 23 , 24 , 25 , 26 ]. Pure ibuprofen, ketoprofen, and drotaverine hydrochloride were the subject of several FTIR studies [ 27 , 28 , 29 , 30 , 31 , 32 ] using different techniques but to the best of our knowledge, their mixtures were never studied before.…”

Section: Resultsmentioning

confidence: 99%

Compatibility of Drotaverine Hydrochloride with Ibuprofen and Ketoprofen Nonsteroidal Anti-Inflammatory Drugs Mixtures

et al. 2022

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Formulations with two or more active pharmaceutical ingredients (APIs) are a researched trend due to their convenient use compared with multiple medications. Moreover, drug-drug combinations may have a synergistic effect. Drotaverine hydrochloride (D-HCl) is commonly used for its antispasmodic action. The combination of a spasmolytic and an analgesic drug such as ibuprofen (Ibu) or ketoprofen (Ket) could become the answer for the treatment of localized pain. D-HCl:Ibu and D-HCl:Ket drug-drug interactions leading to the formation of eutectic compositions with increased bioavailability, obtained by mechanosynthesis, a green, solvent-free method was explored for the first time. The compatibility of Ibuprofen, Ketoprofen, and Drotaverine Hydrochloride was investigated using differential scanning calorimetry (DSC), X-ray diffraction (XRD), and Fourier-Transform Infrared spectroscopy (FTIR). Solid-liquid equilibrium (SLE) phase diagrams for the binary systems of active pharmaceutical ingredients were developed and the Tammann diagrams were designed to determine the eutectic compositions. The excess thermodynamic functions GE for the pre-, post-, and eutectic compositions were obtained using the computed activity coefficients data. Results show that drotaverine-based pharmaceutical forms for pain treatment may be obtained at 0.9 respectively 0.8 molar fractions of ibuprofen and ketoprofen which is advantageous because the maximum allowed daily dose of Ibu is about 6 times higher than those of D-HCl and Ket. The obtained eutectics may be a viable option for the treatment of pain associated with cancer therapy.

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Section: Resultsmentioning

confidence: 99%

Compatibility of Drotaverine Hydrochloride with Ibuprofen and Ketoprofen Nonsteroidal Anti-Inflammatory Drugs Mixtures

et al. 2022

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“…The band at (3196 cm -1 ) assigned to υ(O-H) (Pimsin et al, 2021) E), this band has been shifted to a higher frequency for the Mn(II), Co(II), Ni(II), and Cu(II)metal ion complexes at range of (3211-3221 cm -1 ) (Mushtaque et al, 2017) in comparison to that of the free ligand, as a result of the coordination between the ligand and metal ion. The band at (2970 cm -1 ) assign to the υ(C 6 H 6 ) ring (Meltzer et al, 2021), and the band at (1691 cm -1 ) of the υ(C=N) (Mondal et al, 2021) of the ligand these two bands has been shifted to a lower frequency for all the formed complexes, affected by the coordination. Furthermore, the bands at the range of (416-434 cm -1 ) are due to υ(M-N) (Liao et al, 2001, El-Boraey et al, 2016 and (486-524 cm -1 ) range of υ(M-O) (Liao et al, 2001, El-Boraey et al, 2016 for Mn(II), Co(II), Ni(II), and Cu(II) metal ion complexes respectively.…”

Section: Synthesis and Characterization Of Derivative Ligand Type [Lh...mentioning

confidence: 96%

New schiff base ligand type [LH2] donor derevative from 4-Aminophenol with Manganese (II), Cobalt(II), Nickal(II), and Copper(II)

2023

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The condensation reaction between dimethylglyoxime, acetic acid, and 4-aminophenol was significantly influenced by the [LH 2 ] type donor derivative ligand. The reaction was conducted in methanol for 24 hours while being stirred and refluxed. The syntheses forming a new (2E,3E)-butane-2,3-dione O2-. Spectroscopic techniques (FT-IR and UV-Vis), elemental analysis (CHN), magnetic susceptibility testing, thin-layer chromatography (TLC), X-RD powder diffraction, 1 H-NMR molar conductance, and other methods have been used to characterize the ligand and its complexes with the general formula [M(LH 2 )] where [M= Mn(II), Co(II), Ni(II), and Cu(II), and [LH 2 ] = donor atoms ligand with N 4 and O]. Our study reveals the formation of a new ligand and new complexes with trigonal bipyramid geometrical shape around the Manganese(II), Cobalt(II), Nickel(II), and Copper(II) metal ions. Biological function using the agar disc diffusion method for the ligand and its complexes showed considerable activity against one kind of bacteria (Staphylococcus aureus) after being exposed to two types of bacteria (Staphylococcus aureus and Escherichia coli).

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“…To the best of our knowledge, only DSC data of pure nimesulide and, respectively, salicylic acid are found in the literature [24][25][26][27]. FTIR spectroscopy is widely used in conjunction with DSC and/or other techniques to characterize chemical structure modifications and molecular interactions in any physical state due to the high selectivity, low analysis costs and rapid sample preparation [21,22,[30][31][32].…”

Section: Introductionmentioning

confidence: 99%

Thermal Behavior of the Nimesulide-Salicylic Acid Eutectic Mixtures Prepared by Mechanosynthesis and Recrystallization

et al. 2021

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Nimesulide, salicylic acid and their binary mixtures were studied by differential scanning calorimetry (DSC) and Fourier Transform Infrared spectroscopy (FTIR). The study of such systems is a promising and viable approach for solving the problem of poor solubility of materials in general and drug systems in particular. All areas of human activity are inextricably linked to materials, and thus, the study presented in the paper and not reported in the literature is very important and provides useful data for those working in various fields. The eutectic mixtures were obtained by mechanosynthesis and by recrystallization from ethanol over the entire 0–1 range of molar fractions. For both situations at the molar fraction of nimesulide 0.5, the mixture has a eutectic that suggests an increase in solubility at this composition. The interactions that take place between the components were determined with the help of the excess thermodynamic functions (GE, SE, µE), which highlight the deviation from the ideality of the considered binary systems.

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Physico-chemical characterization of solid state reaction between terephtalaldehyde and p-aminophenol

Cited by 3 publications

References 12 publications

Compatibility of Drotaverine Hydrochloride with Ibuprofen and Ketoprofen Nonsteroidal Anti-Inflammatory Drugs Mixtures

Compatibility of Drotaverine Hydrochloride with Ibuprofen and Ketoprofen Nonsteroidal Anti-Inflammatory Drugs Mixtures

New schiff base ligand type [LH2] donor derevative from 4-Aminophenol with Manganese (II), Cobalt(II), Nickal(II), and Copper(II)

Thermal Behavior of the Nimesulide-Salicylic Acid Eutectic Mixtures Prepared by Mechanosynthesis and Recrystallization

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