Physico-chemical characteristics, biocompatibility, and MRI applicability of novel monodisperse PEG-modified magnetic Fe3O4&amp;SiO2core–shell nanoparticles

Kostiv, Uliana; Patsula, Vitalii; Šlouf, Miroslav; Pongrac, I; Škokić, Siniša; Radmilović, Marina Dobrivojević; Pavičić, Ivan; Vrček, Ivana Vinković; Gajović, Srećko; Horák, Daniel

doi:10.1039/c7ra00224f

Cited by 46 publications

(21 citation statements)

References 52 publications

(58 reference statements)

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“…For silica shells grown onto iron oxide NPs using an inverse microemulsion, it was shown that the thickness of the shell increases as the amount of TEOS increases, while core-free silica NPs appear when the TEOS content exceeds the threshold of homogeneous nucleation [36,39,[47][48][49]. Typically, a maximum diameter <50 nm can be reached with this technique [23].…”

Section: Introductionmentioning

confidence: 99%

Coating of upconversion nanoparticles with silica nanoshells of 5–250 nm thickness

Kembuan¹,

Saleh²,

Rühle³

et al. 2019

Beilstein J. Nanotechnol.

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A concept for the growth of silica shells with a thickness of 5–250 nm onto oleate-coated NaYF4:Yb3+/Er3+ upconversion nanoparticles (UCNP) is presented. The concept enables the precise adjustment of shell thicknesses for the preparation of thick-shelled nanoparticles for applications in plasmonics and sensing. First, an initial 5–11 nm thick shell is grown onto the UCNPs in a reverse microemulsion. This is followed by a stepwise growth of these particles without a purification step, where in each step equal volumes of tetraethyl orthosilicate and ammonia water are added, while the volumes of cyclohexane and the surfactant Igepal® CO-520 are increased so that the ammonia water and surfactant concentrations remain constant. Hence, the number of micelles stays constant, and their size is increased to accommodate the growing core–shell particles. Consequently, the formation of core-free silica particles is suppressed. When the negative zeta potential of the particles, which continuously decreased during the stepwise growth, falls below −40 mV, the particles can be dispersed in an ammoniacal ethanol solution and grown further by the continuous addition of tetraethyl orthosilicate to a diameter larger than 500 nm. Due to the high colloidal stability, a coalescence of the particles can be suppressed, and single-core particles are obtained. This strategy can be easily transferred to other nanomaterials for the design of plasmonic nanoconstructs and sensor systems.

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Section: Introductionmentioning

confidence: 99%

Coating of upconversion nanoparticles with silica nanoshells of 5–250 nm thickness

Kembuan¹,

Saleh²,

Rühle³

et al. 2019

Beilstein J. Nanotechnol.

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“…/Er 3 + particles were modified with as ilica shell using aw ater-in-oil microemulsion technique. [25,34] Briefly,N aYF 4 :Yb 3 + /Er 3 + (30 mg) nanoparticle dispersion in hexane (10 mL), 25 %N H 4 OH (0.08 mL), and Igepal CO-520 (0.5 mL) were sonicated for 20 min to form a transparent colloid. TMOS (0.04 mL) was added, and the reaction mixture was stirred (600 rpm) at RT for 48 h. To obtain methacrylate-functionalized nanospheres (NaYF 4 :Yb 3 + /Er 3 + @SiO 2 -MA), TSPMA (0.02 mL) was added to NaYF 4 :Yb 3 + /Er 3 + @SiO 2 particles, and the dispersion was stirred at RT for 24 h. Finally,N aYF 4 :Yb 3 + /Er 3 + @SiO 2 and/or NaYF 4 :Yb 3 + /Er 3 + @SiO 2 -MA nanospheres were precipitated by acetone (10 mL), washed with ethanol and water three times each, transferred in water,a nd kept at 4 8C.…”

Section: /Ermentioning

confidence: 99%

Phthalocyanine‐Conjugated Upconversion NaYF₄:Yb³⁺/Er³⁺@SiO₂ Nanospheres for NIR‐Triggered Photodynamic Therapy in a Tumor Mouse Model

et al. 2017

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Photodynamic therapy (PDT) has garnered immense attention as a minimally invasive clinical treatment modality for malignant cancers. However, its low penetration depth and photodamage of living tissues by UV and visible light, which activate a photosensitizer, limit the application of PDT. In this study, monodisperse NaYF4:Yb3+/Er3+ nanospheres 20 nm in diameter, that serve as near‐infrared (NIR)‐to‐visible light converters and activators of a photosensitizer, were synthesized by high‐temperature co‐precipitation of lanthanide chlorides in a high‐boiling organic solvent (octadec‐1‐ene). The nanoparticles were coated with a thin shell (≈3 nm) of homogenous silica via the hydrolysis and condensation of tetramethyl orthosilicate. The NaYF4:Yb3+/Er3+@SiO2 particles were further functionalized by methacrylate‐terminated groups via 3‐(trimethoxysilyl)propyl methacrylate. To introduce a large number of reactive amino groups on the particle surface, methacrylate‐terminated NaYF4:Yb3+/Er3+@SiO2 nanospheres were modified with a branched polyethyleneimine (PEI) via Michael addition. Aluminum carboxyphthalocyanine (Al Pc‐COOH) was then conjugated to NaYF4:Yb3+/Er3+@SiO2‐PEI nanospheres via carbodiimide chemistry. The resulting NaYF4:Yb3+/Er3+@SiO2‐PEI‐Pc particles were finally modified with succinimidyl ester of poly(ethylene glycol) (PEG) in order to alleviate their future uptake by the reticuloendothelial system. Upon 980 nm irradiation, the intensive red emission of NaYF4:Yb3+/Er3+@SiO2‐PEI‐Pc‐PEG nanoparticles completely vanished, indicating efficient energy transfer from the nanoparticles to Al Pc‐COOH, which generates singlet oxygen (1O2). Last but not least, NaYF4:Yb3+/Er3+@SiO2‐PEI‐Pc‐PEG nanospheres were intratumorally administered into mammary carcinoma MDA‐MB‐231 growing subcutaneously in athymic nude mice. Extensive necrosis developed at the tumor site of all mice 24–48 h after irradiation by laser at 980 nm wavelength. The results demonstrate that the NaYF4:Yb3+/Er3+@SiO2‐PEI‐Pc‐PEG nanospheres have great potential as a novel NIR‐triggered PDT nanoplatform for deep‐tissue cancer therapy.

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“…Its promising properties such as low cost, high thermal stability, resistance towards corrosion, tuneable magnetic and optical properties, non-toxic/benign nature towards environment as well as living tissues makes a-Fe 2 O 3 worthy to investigate. 2,[4][5][6][7] Till date, a-Fe 2 O 3 NPs with diverse morphologies such as nanoowers, 8 nanotubes, 9 nanodiscs, 10 polyhedrals, 10 nanoplates 5 and needles, 11 which show morphology dependent properties, have been reported.…”

Section: Introductionmentioning

confidence: 99%

“…This journal is © The Royal Society of Chemistry 2019 NPs, respectively in the same time frame. Moreover, only 5% degradation of RhB dye in the absence of catalyst and H2 O 2 and 8% using MIL ([C 16 min][FeCl 4 ] as representative) and H 2 O 2 under sunlight(Fig. 5B)is observed, which conrms the role of a-Fe 2 O 3 NPs.…”

mentioning

confidence: 98%

Sustainable preparation of sunlight active α-Fe₂O₃nanoparticles using iron containing ionic liquids for photocatalytic applications

et al. 2019

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Physico-chemical characteristics, biocompatibility, and MRI applicability of novel monodisperse PEG-modified magnetic Fe₃O₄&SiO₂core–shell nanoparticles

Abstract: Biocompatible monodisperse PEG-modified magnetic Fe3O4&SiO2 core–shell nanoparticles with controlled size provided sufficient contrast for magnetic resonance imaging (MRI).

Cited by 46 publications

References 52 publications

Coating of upconversion nanoparticles with silica nanoshells of 5–250 nm thickness

Coating of upconversion nanoparticles with silica nanoshells of 5–250 nm thickness

Phthalocyanine‐Conjugated Upconversion NaYF₄:Yb³⁺/Er³⁺@SiO₂ Nanospheres for NIR‐Triggered Photodynamic Therapy in a Tumor Mouse Model

Sustainable preparation of sunlight active α-Fe₂O₃nanoparticles using iron containing ionic liquids for photocatalytic applications

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Physico-chemical characteristics, biocompatibility, and MRI applicability of novel monodisperse PEG-modified magnetic Fe3O4&SiO2core–shell nanoparticles

Abstract: Biocompatible monodisperse PEG-modified magnetic Fe3O4&SiO2 core–shell nanoparticles with controlled size provided sufficient contrast for magnetic resonance imaging (MRI).

Cited by 46 publications

References 52 publications

Coating of upconversion nanoparticles with silica nanoshells of 5–250 nm thickness

Coating of upconversion nanoparticles with silica nanoshells of 5–250 nm thickness

Phthalocyanine‐Conjugated Upconversion NaYF4:Yb3+/Er3+@SiO2 Nanospheres for NIR‐Triggered Photodynamic Therapy in a Tumor Mouse Model

Sustainable preparation of sunlight active α-Fe2O3nanoparticles using iron containing ionic liquids for photocatalytic applications

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Physico-chemical characteristics, biocompatibility, and MRI applicability of novel monodisperse PEG-modified magnetic Fe₃O₄&SiO₂core–shell nanoparticles

Phthalocyanine‐Conjugated Upconversion NaYF₄:Yb³⁺/Er³⁺@SiO₂ Nanospheres for NIR‐Triggered Photodynamic Therapy in a Tumor Mouse Model

Sustainable preparation of sunlight active α-Fe₂O₃nanoparticles using iron containing ionic liquids for photocatalytic applications