Physico-chemical characteristics and cytotoxicity evaluation of CuO and TiO2 nanoparticles biosynthesized using extracts of Mucuna pruriens utilis seeds

Gamedze, Nozipho P.; Mthiyane, Doctor Mziwenkosi Nhlanhla; Babalola, Olubukola Oluranti; Singh, Moganavelli; Onwudiwe, Damian C.

doi:10.1016/j.heliyon.2022.e10187

Cited by 14 publications

(9 citation statements)

References 59 publications

(68 reference statements)

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“…The results assessed these nanoparticles' antioxidant efficacy through the DPPH and FRAP assays, affirming their robust antioxidant properties. These findings emphasize the immense potential of functionalized Nb-N-TiO 2 NPs in biomedical applications, spanning domains such as drug delivery, diagnostics, and therapeutics [ 48 ]. This study underscores the substantial promise offered by doped titanium dioxide nanoparticles in various biomedical fields, paving the way for continued research and development to further enhance their utility in diverse biomedical applications [ 28 ].…”

Section: Discussionmentioning

confidence: 91%

“…A remarkable spectacle unfolds when we focus on the functionalized Nb-N-TiO 2 NPs, revealing a triangular aggregation pattern ranging from 500 nm to 2 µm, captured in Fig. 4 [ 48 ]. These variances in shape and size in the SEM images emphasize the profound influence of capping active phytochemicals derived from the ethanolic extracts of M. arvensis upon the doped Nb-N-TiO 2 NPs morphology [ 55 ].…”

Section: Resultsmentioning

confidence: 99%

“…The ensuing pellet was systematically discarded, while the supernatant was harmoniously merged with an equal volume of double-distilled water and 0.1% (1 mL) ferric chloride (FeCl 3 ). Subsequently, the absorbance magnitude was discerningly quantified at a precise wavelength of 700 nm, employing the specificity and reliability of a Spark multi-plate reader (Tecan) [ 48 ]. This methodical approach optimizes the antioxidant potential of materials, offering profound insights into the reducing potential of ethanolic M. arvensis extracts, pure Nb-N-TiO 2 and functionalized Nb-N-TiO 2 [ 49 ].…”

Section: Characterization Of Nb-n-tio 2 Npsmentioning

confidence: 99%

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Functionalization of niobium nitrogen-doped titanium dioxide (TiO2) nanoparticles with ethanolic extracts of Mentha arvensis

Farooqi,

Bhatti

et al. 2024

Discover Nano

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Titanium dioxide (TiO2) nanoparticles have gained significant attention due to their wide-ranging applications. This research explores an approach to functionalize Niobium Nitrogen Titanium Dioxide nanoparticles (Nb-N-TiO2 NPs) with Mentha arvensis ethanolic leaf extracts. This functionalization allows doped NPs to interact with the bioactive compounds in extracts, synergizing their antioxidant activity. While previous studies have investigated the antioxidant properties of TiO2 NPs synthesized using ethanolic extracts of Mentha arvensis, limited research has focused on evaluating the antioxidant potential of doped nanoparticles functionalized with plant extracts. The characterization analyses are employed by Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and Ultraviolet–visible (UV–Vis) spectroscopy to evaluate these functionalized doped nanoparticles thoroughly. Subsequently, the antioxidant capabilities through the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric-reducing antioxidant power (FRAP) assays have been assessed. Within functionalized Nb-N-TiO2, the FTIR has a distinctive peak at 2350, 2010, 1312, 1212, and 1010 cm−1 with decreased transmittance associated with vibrations linked to the Nb-N bond. SEM revealed a triangular aggregation pattern, 500 nm to 2 µm of functionalized Nb-N-TiO2 NPs. Functionalized doped Nb-N-TiO2 NPs at 500 µg mL−1 exhibited particularly robust antioxidant activity, achieving an impressive 79% efficacy at DPPH assessment; meanwhile, ferric reduction efficiency of functionalized doped Nb-N-TiO2 showed maximum 72.16%. In conclusion, doped Nb-N-TiO2 NPs exhibit significantly enhanced antioxidant properties when functionalized with Mentha arvensis ethanolic extract compared to pure Nb-N-TiO2 manifested that doped Nb-N-TiO2 have broad promising endeavors for various biomedicine applications.

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Section: Discussionmentioning

confidence: 91%

Section: Resultsmentioning

confidence: 99%

Section: Characterization Of Nb-n-tio 2 Npsmentioning

confidence: 99%

See 1 more Smart Citation

Functionalization of niobium nitrogen-doped titanium dioxide (TiO2) nanoparticles with ethanolic extracts of Mentha arvensis

Farooqi,

Bhatti

et al. 2024

Discover Nano

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“…However, doxorubicin which is the toxic anticancer agent used in this study as a reference was toxic to HEK 293 cells with an LC 50 = 1.20 ± 1.09 μg/mL. The cytotoxicity of CuO biosynthesized using extracts of seeds of Mucuna pruriens utilis IC 50 = 42.33 μg/mL against HEK 293 cells [ 32 ]. The latter concurs with our finding that CuO biosynthesized A. phylicoides NPs are none toxic to normal cells, therefore, are safe for the development of therapeutic drugs.…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial, antioxidant, and cytotoxic properties of biosynthesized copper oxide nanoparticles (CuO-NPs) using Athrixia phylicoides DC

Kaningini¹,

Motlhalamme²,

More³

et al. 2023

Heliyon

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“…For the synthesis of the CuO nanoparticles, the method reported by Gamedze, Mthiyane, Babalola, Singh and Onwudiwe [19] with slight modification was used. In a typical synthesis, about 2.5 g of copper(II) nitrate hemipentahydrate was dissolved in 20 ml of distilled water.…”

Section: Biosynthesis Of Cuo Nanoparticlesmentioning

confidence: 99%

Green synthesis of CuO nanoparticles using Ligustrum lucidum extract, and the antioxidant and antifungal evaluation

Ogwuegbu,

Ayangbenro,

Mthiyane

et al. 2024

Mater. Res. Express

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Biosynthesis of metal oxide nanoparticles using plant extract is an inexpensive, simple, rapid, and environmentally friendly approach to obtaining nanoparticles for biological applications. Herein, copper oxide nanoparticles (CuO-NPs) were successfully synthesized using an aqueous extract from Ligustrum lucidum leaves. The structural, optical, and morphological characteristics of the nanoparticles were assessed using X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, UV-visible spectrophotometer, transmission and scanning electron microscopy (TEM and SEM), and energy-dispersive X-ray (EDX). Nanocrystalline CuO with an average crystalline size of 22.0 nm and a band gap energy of 1.4 eV were confirmed from the XRD and UV vis spectrophotometer, respectively. Morphological studies showed spherical nanoparticles, whose particle size estimation (30±5 nm) agrees with the crystalline size deduced from the XRD pattern. A free radical scavenging activity of the CuO nnanoparticles, evaluated using the 1, 1-diphenhyl-2-picrylhydrazyl (DPPH) assay, showed that it exhibited high antioxidant activity (IC50: 63.35 µg/mL) that is concentration dependent. Antifungal evaluation using four different fungal strains (Aspergillus flavus, Aspergillus niger, Fusarium oxysporum, and Trichoderma harzianum) indicated a direct relationship between the potency of the particles and their concentration, with 1 ppm solution exhibiting the highest potency. The green synthesized CuO-NPs using Ligustrum lucidum may be potentially used as an antioxidant and antifungal agent for therapeutic applications.

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Physico-chemical characteristics and cytotoxicity evaluation of CuO and TiO2 nanoparticles biosynthesized using extracts of Mucuna pruriens utilis seeds

Cited by 14 publications

References 59 publications

Functionalization of niobium nitrogen-doped titanium dioxide (TiO2) nanoparticles with ethanolic extracts of Mentha arvensis

Functionalization of niobium nitrogen-doped titanium dioxide (TiO2) nanoparticles with ethanolic extracts of Mentha arvensis

Antimicrobial, antioxidant, and cytotoxic properties of biosynthesized copper oxide nanoparticles (CuO-NPs) using Athrixia phylicoides DC

Green synthesis of CuO nanoparticles using Ligustrum lucidum extract, and the antioxidant and antifungal evaluation

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