Physico-Chemical and Biological Studies on Actinoxanthin, an Antibiotic From Actinomyces Globisporus 1131

Khokhlov, A. S.; Cherches, B. Z.; Reshetov, P. D.; Smirnova, G. M.; Sorokina, I B; Prokoptzeva, T. A.; Koloditskaya, T. A.; Смірнов, В. В.; Navashin, S M; Fomina, I P

doi:10.7164/antibiotics.22.541

Cited by 41 publications

(9 citation statements)

References 5 publications

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“…Degradation studies on the auromomycin chromophore indicate that it contains a benzoxazine side chain identical to that found in C-1027. 102 Similarly, actinoxanthin 95,96 is an antitumor chromoprotein antibiotic isolated from Actinomyces globisporus No. 1131 in 1957.…”

Section: The Calicheamicins and Esperamicinsmentioning

confidence: 99%

The Enediyne Antibiotics

1996

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Section: The Calicheamicins and Esperamicinsmentioning

confidence: 99%

The Enediyne Antibiotics

1996

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“…F-41 [l] is a member of the macromolecular antitumour antibiotic family which also includes actinoxanthin (AXN) [2] and auromomycin [3]. NCS has been clinically used for treatment of bladder and liver cancer .…”

mentioning

confidence: 99%

Crystal structure of apo‐neocarzinostatin at 0.15‐nm resolution

Teplyakov¹,

Obmolova²,

Wilson³

et al. 1993

European Journal of Biochemistry

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The three-dimensional structure of apo-neocarzinostatin, an antitumour antibiotic protein isolated from Streptomyces curzinostuticus, has been determined by X-ray diffraction at 0.15-nm resolution and refined to R = 17.2%. The crystal structure of neocarzinostatin is similar to that of the related proteins actinoxanthin and macromomycin. It is also in good agreement with the solution structure determined by NMR spectroscopy. The protein molecule consists of a seven-stranded antiparallel P-sandwich and a smaller lobe formed by two P-ribbons. A deep cleft between the two lobes is a putative chromophore binding site. Side chains of Trp39, Leu45, Phe52, Phe78 and the disulphide Cys37-Cys47 aligning the binding cleft in neocarzinostatin suggest the importance of hydrophobic interactions in stabilizing the chromophore molecule. Comparison of the atomic models of neocarzinostatin, actinoxanthin and macromomycin reveals functional residues which might determine specificity towards different chromophores.

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“…Among representatives of S. globisporus the producers of antitumor antibiotics lidamycin, landomycins and actinoxanthins, which also possess antibacterial properties, were described. Antifungal activity has not been previously described [23,24,25,26,27,28]. It is possible that strain S. globisporus INA 01180 forms one of these antibiotics, as well as an unidentified antifungal antibiotic.…”

Section: Resultsmentioning

confidence: 99%

Antibiotic Activity of Actinobacteria from the Digestive Tract of Millipede Nedyopus dawydoffiae (Diplopoda)

et al. 2018

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Because of the spread of drug resistance, it is necessary to look for new antibiotics that are effective against pathogenic microorganisms. The purpose of this study was to analyse the species composition of actinobacteria isolated from the digestive tract of the millipedes Nedyopus dawydoffiae and to determine their antimicrobial properties. Species identification was carried out on the basis of the morphological and culture properties and the sequence of the 16S rRNA gene. Actinobacteria were grown in different liquid media. Antibiotic properties were determined against some Gram-positive and Gram-negative bacteria as well as fungi. Of the 15 isolated strains, 13 have antibiotic activity against Gram-positive bacteria (including methicillin-resistant Staphylococcus aureus—MRSA) and fungi, but there was no antibiotic activity against Gram-negative test strains Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 27853. It was established that antibiotic-producing actinobacteria belong to eight species of the genus Streptomyces. Depending on the nutrient medium, actinobacteria demonstrate different antimicrobial activities. As an example, S. hydrogenans shows that even strains selected in one population differ by the range of antimicrobial activity and the level of biosynthesis. Since the antibiotic production is considered as a feature for species competition in the microbiota community, the variability of antibiotic production among different strains of the same species is an adaptive characteristic for the competition in millipedes’ digestive tract community.

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Physico-Chemical and Biological Studies on Actinoxanthin, an Antibiotic From Actinomyces Globisporus 1131

Cited by 41 publications

References 5 publications

The Enediyne Antibiotics

The Enediyne Antibiotics

Crystal structure of apo‐neocarzinostatin at 0.15‐nm resolution

Antibiotic Activity of Actinobacteria from the Digestive Tract of Millipede Nedyopus dawydoffiae (Diplopoda)

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