Physico-chemical and biological considerations for membrane wound evolution and repair in animal cells

Jiménez, Ana Joaquina; Perez, Franck

doi:10.1016/j.semcdb.2015.09.023

Cited by 29 publications

(26 citation statements)

References 112 publications

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“…The molecular players involved in cell splitting might be similar to those involved in the final stages of cytokinesis (abscission) during mitosis (reviewed in Fededa and Gerlich, 2012). Alternatively, and more likely, splitting of the cell membrane might result in small lesions that are sealed by generic membrane healing processes (Jimenez and Perez, 2015). Using available molecular markers for each of these processes and analyzing them during angiogenesis might provide some initial insights into the possible molecular mechanisms involved in cell splitting.…”

Section: Endothelial Cell Splittingmentioning

confidence: 99%

Cell behaviors and dynamics during angiogenesis

et al. 2016

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Vascular networks are formed and maintained through a multitude of angiogenic processes, such as sprouting, anastomosis and pruning. Only recently has it become possible to study the behavior of the endothelial cells that contribute to these networks at a single-cell level in vivo. This Review summarizes what is known about endothelial cell behavior during developmental angiogenesis, focusing on the morphogenetic changes that these cells undergo.

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Section: Endothelial Cell Splittingmentioning

confidence: 99%

Cell behaviors and dynamics during angiogenesis

et al. 2016

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“…Transient PM lesions still occur in healthy conditions, particularly, in tissues under high mechanical stress or biochemical stress such as muscle, skin, or gut epithelia [4, 5]. Conversely, persistent PM damage hallmarks several pathologies, such as heart failure, neurodegeneration, and infection [6–9]. …”

Section: Introductionmentioning

confidence: 99%

Mechanisms protecting host cells against bacterial pore-forming toxins

Brito

Cabanes

Mesquita

et al. 2018

Cell. Mol. Life Sci.

109

142

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Pore-forming toxins (PFTs) are key virulence determinants produced and secreted by a variety of human bacterial pathogens. They disrupt the plasma membrane (PM) by generating stable protein pores, which allow uncontrolled exchanges between the extracellular and intracellular milieus, dramatically disturbing cellular homeostasis. In recent years, many advances were made regarding the characterization of conserved repair mechanisms that allow eukaryotic cells to recover from mechanical disruption of the PM membrane. However, the specificities of the cell recovery pathways that protect host cells against PFT-induced damage remain remarkably elusive. During bacterial infections, the coordinated action of such cell recovery processes defines the outcome of infected cells and is, thus, critical for our understanding of bacterial pathogenesis. Here, we review the cellular pathways reported to be involved in the response to bacterial PFTs and discuss their impact in single-cell recovery and infection.

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“…Inundation with reactive oxygen species and other toxic molecules may cause further damage to endogenous proteins and biomolecules 49 . Thus, cells urgently deploy repair pathways to reseal membrane disruptions and recover from the damage imposed (see recent reviews [70][71][72][73][74] ).…”

mentioning

confidence: 99%

In vitro and ex vivo strategies for intracellular delivery

Stewart¹,

Sharei²,

Ding³

et al. 2016

Nature

709

742

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Although carrier-mediated delivery systems offer promise for nucleic acid transfection in vivo 1,2 , membrane-disruption-based modalities are attractive candidates for universal delivery systems in vitro and ex vivo. In this review, we begin with motivations driving next-generation intracellular delivery strategies and suggest relevant requirements for future systems. Next, a broad overview of current delivery concepts covering salient strengths, challenges and opportunities is presented. Following that, our focus shifts to prevalent mechanisms of membrane disruption and recovery in the context of intracellular delivery. Finally,

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Physico-chemical and biological considerations for membrane wound evolution and repair in animal cells

Cited by 29 publications

References 112 publications

Cell behaviors and dynamics during angiogenesis

Cell behaviors and dynamics during angiogenesis

Mechanisms protecting host cells against bacterial pore-forming toxins

In vitro and ex vivo strategies for intracellular delivery

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