“…130 Furthermore, several components in ginseng inhibit platelet aggregation, 131 and several reports recorded bleeding in women after using products containing ginseng. 132,133 Co-administration of xuesaitong dispersible tablet (0.8 g/kg), which contains P. notoginseng saponins such as ginsenoside Rg1, Rd, and R1, and aspirin altered AUC, C max , T max , V d (volume of distribution), as well as CL (plasma clearance) of R1 and Rg1, but did not significantly affect pharmacokinetic parameters of aspirin in blood stasis rats, implying a ginseng-aspirin interaction involving R1 and Rg1 absorption, distribution, and disposition. 134 No clinical ginseng-aspirin interactions have been reported to date, but concomitant use of aspirin and ginseng products may aggravate bleeding tendencies.…”