Physicians Who Move

Coe, Robert C.

doi:10.1001/jama.1983.03330390026011

Cited by 1 publication

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“…130 Furthermore, several components in ginseng inhibit platelet aggregation, 131 and several reports recorded bleeding in women after using products containing ginseng. 132,133 Co-administration of xuesaitong dispersible tablet (0.8 g/kg), which contains P. notoginseng saponins such as ginsenoside Rg1, Rd, and R1, and aspirin altered AUC, C max , T max , V d (volume of distribution), as well as CL (plasma clearance) of R1 and Rg1, but did not significantly affect pharmacokinetic parameters of aspirin in blood stasis rats, implying a ginseng-aspirin interaction involving R1 and Rg1 absorption, distribution, and disposition. 134 No clinical ginseng-aspirin interactions have been reported to date, but concomitant use of aspirin and ginseng products may aggravate bleeding tendencies.…”

Section: Aspirinmentioning

confidence: 99%

Phytochemical and Over-The-Counter Drug Interactions: Involvement of Phase I and II Drug-Metabolizing Enzymes and Phase III Transporters

Truong

Jun

Jeong

2021

Journal of Medicinal Food

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Consumption of plant-derived natural products and over-the-counter (OTC) drugs is increasing on a global scale, and studies of phytochemical-OTC drug interactions are becoming more significant. The intake of dietary plants and herbs rich in phytochemicals may affect drug-metabolizing enzymes (DMEs) and transporters. These effects may lead to alterations in pharmacokinetics and pharmacodynamics of OTC drugs when concomitantly administered. Some phytochemical-drug interactions benefit patients through enhanced efficacy, but many interactions cause adverse effects. This review discusses possible mechanisms of phytochemical-OTC drug interactions mediated by phase I and II DMEs and phase III transporters. In addition, current information is summarized for interactions between phytochemicals derived from fruits, vegetables, and herbs and OTC drugs, and counseling is provided on appropriate and safe use of OTC drugs.

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