“…Lung cancer is accompanied by the occurrence of peripheral nodular shadows and subpleural consolidation with irregular margins of thin-walled cavities and an elevation of the diaphragm [11,12,13]. Regardless of all radiographic differences, lung cancer and tuberculosis cannot be differentiated with certainty [11].…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, it is important to educate doctors, especially in smaller centers, to recognize the early signs and symptoms of the two diseases in order for them to be diagnosed in time [12]. The gold standard is a histological confirmation coupled with microbiological analyses.…”
Abstract. Simultaneous occurrence of lung cancer and pulmonary tuberculosis, as a significant cause of morbidity and mortality, appears in 0.7% of cases. The mechanisms of interaction between them are not fully clarified. We present a patient who, during the treatment of lung adenocarcinoma, developed pulmonary tuberculosis and, owing to a correct diagnosis, was provided with appropriate treatment. We analyzed the CT and radiographic findings during the follow-up of the patient and discussed the problems and doubts about the diagnosis of simultaneous occurrence of lung cancer and pulmonary tuberculosis. Differential diagnosis between tuberculosis and lung cancer is difficult and can pose a real clinical challenge due to the very similar symptomatology involving fever, malaise, sweating, and loss of body weight. Imaging methods routinely used in clinics, such as RTG, CT, and PET-CT, are of great help in such cases. The existence of the TB infection makes it difficult to adequately determine the nodal status in patients with lung cancer. The newly established lymph nodes may not only be the occurrence of tumors, but also already active tuberculosis or the progression of TB infection. Only the correct diagnosis can lead to successful treatment as described in this case.
“…Lung cancer is accompanied by the occurrence of peripheral nodular shadows and subpleural consolidation with irregular margins of thin-walled cavities and an elevation of the diaphragm [11,12,13]. Regardless of all radiographic differences, lung cancer and tuberculosis cannot be differentiated with certainty [11].…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, it is important to educate doctors, especially in smaller centers, to recognize the early signs and symptoms of the two diseases in order for them to be diagnosed in time [12]. The gold standard is a histological confirmation coupled with microbiological analyses.…”
Abstract. Simultaneous occurrence of lung cancer and pulmonary tuberculosis, as a significant cause of morbidity and mortality, appears in 0.7% of cases. The mechanisms of interaction between them are not fully clarified. We present a patient who, during the treatment of lung adenocarcinoma, developed pulmonary tuberculosis and, owing to a correct diagnosis, was provided with appropriate treatment. We analyzed the CT and radiographic findings during the follow-up of the patient and discussed the problems and doubts about the diagnosis of simultaneous occurrence of lung cancer and pulmonary tuberculosis. Differential diagnosis between tuberculosis and lung cancer is difficult and can pose a real clinical challenge due to the very similar symptomatology involving fever, malaise, sweating, and loss of body weight. Imaging methods routinely used in clinics, such as RTG, CT, and PET-CT, are of great help in such cases. The existence of the TB infection makes it difficult to adequately determine the nodal status in patients with lung cancer. The newly established lymph nodes may not only be the occurrence of tumors, but also already active tuberculosis or the progression of TB infection. Only the correct diagnosis can lead to successful treatment as described in this case.
“…The total sample size from primary studies was 3133 participants. An average of 2233 were predominately male from nine studies and 803 females [33][34][35][36][37][38][39][40][41], one study [42] did not specify on the sex of the participants. About smoking status, six studies showed significant male predominance [33-35, 38, 40, 41].…”
Section: Characteristics Of Included Studiesmentioning
confidence: 99%
“…About smoking status, six studies showed significant male predominance [33-35, 38, 40, 41]. Of the ten included studies, 4 were retrospective studies [33,34,36,41]; 3 were prospective studies [38,40,42]; 2 were descriptive studies [37,39] and 1 was cross-sectional study [35]. All the ten studies described at least one interval in lung cancer care.…”
Section: Characteristics Of Included Studiesmentioning
confidence: 99%
“…All the ten studies described at least one interval in lung cancer care. Three studies reported that most patients visited two or more GPs before a confirmation of their diagnosis [37,40,42]. Eight studies showed median time from symptom onset to diagnosis [33-35, 37-40, 42].…”
Section: Characteristics Of Included Studiesmentioning
Background: Globally, lung cancer is the most common cancer and cause of cancer-related deaths, responsible for nearly one in five deaths. Many health systems in low-and middle-income countries, including sub-Saharan Africa have weak organizational structure, which results in delayed lead time for lung cancer patient care continuum from diagnosis to palliative care. Aim: To map evidence on the health systems issues impacting on the delays in timely lung cancer care continuum from diagnosis to palliative care in LMICs, including sub-Saharan Africa. Methods: A scoping review was performed following the method of Arksey and O'Malley. Systematic searches were performed using EBSCOhost platform, a keyword search from the following electronic databases were conducted: PubMed/MEDLINE, Google Scholar, Science Direct, World Health Organization (WHO) library, and grey literature. The screening was guided by the inclusion and exclusion criteria. The quality of the included studies was determined by Mixed Method Appraisal Tool (MMAT). Results: A total of 2886 articles were screened, and 236 met the eligibility criteria for this scoping review study. Furthermore, 155 articles were also excluded following abstract screening. Eighty-one articles were selected for fullarticle screening by two researchers with 10 being selected for independent detailed data extraction for synthesis. These studies were also subjected to methodological quality assessment. All included studies were conducted in LMICs mostly Asia, the Middle East, and Latin America and published between January 2008 and June 2018. The ten included studies described at least one interval in lung cancer care. Conclusions: Reducing wait time across this care continuum is needed to improve easy access to healthcare, quality care, survival and patient outcomes, as many patients still face longer wait times for diagnosis and treatment of lung cancer than recommended in several healthcare settings. A multidisciplinary team approach will help to reduce wait time and ensure that all patients receive appropriate care. Interventions are needed to address delays in lung cancer care in LMICs. Health-care providers at all levels of care should be educated and equipped with skills to identify lung cancer symptoms and perform or refer for appropriate diagnostic tests.
Introduction Clinical cancer can arise from heterogenous pathways through various genetic mutations. Although we cannot predict the timeline by which an individual will develop cancer, certain risk assessment tools can be used among high-risk groups for focusing the preventive activities. As primary level of cancer prevention, healthy lifestyle approach is being promoted. The etiological factors for lung cancer include by-products of industrialization and air pollution. We need to factor the increase in household air pollution as well.
Methods “PubMed” database and Google search engines were used for searching the relevant articles. Search terms with Boolean operators used include “Cancer prevention,” “Missed opportunities in cancer causation,” and “incidence of risk factors.” This review includes 20 studies and other relevant literature that address the opportunities for cancer prevention.
Body The narrative describes the association between many of the risk factors and development of cancer. This includes tobacco, alcohol, infections, air pollution, physical inactivity, diet, obesity, screening and preventive strategies, chemoprevention, biomarkers of carcinogenesis, and factors that prolong the diagnosis of cancer.
Discussion Reports from basic science research provide evidence on the potential of biologically active food components and pharmacological agents for mitigating the risk of cancer and its progression. However, some reports from observational studies and randomized trials have been inconsistent. We need to recognize the impact of sociodemographic factors such as age, sex, ethnicity, culture, and comorbid illness on preventive interventions. Spiral computed tomographic scan is a robust tool for early detection of lung cancer.
Conclusion Infectious etiology for specific cancers provides opportunities for prevention and treatment. The complex interplay between man and microbial flora needs to be dissected, for understanding the pathogenesis of relevant malignancies. For reducing the morbidity of cancer, we need to focus on prevention as a priority strategy and intervene early during the carcinogenic process.
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