Summary:The purpose of this paper was to (1) comprehensively analyze transplant-related costs for predicted temporal cost shifting and (2) to evaluate whether previous findings of decreasing costs of care persisted using a cost analysis of 353 NHL patients who received autologous stem cell transplantation (SCT) at the University of Nebraska Medical Center. All transplant-related costs between the patient's initial consult and program dismissal were obtained and inflated to constant 1995 dollars. Homogeneous resources were categorized into six cost-drivers and subdivided into outpatient, transplant, and additional inpatient time periods in order to evaluate resource utilization and cost shifting patterns. Between 1989 and 1991 both the average length of stay and comprehensive costs decreased 4.9 days and 14%, respectively. By 1995 additional decreases of 25.7 days and 51% led to an overall 7 year cost decline of 65%. Percent contributions of the six cost-drivers remained similar demonstrating uniformed suppression in transplant-related resource consumption. In contrast, the timing of resource utilization changed dramatically, with transplant hospitalization costs accounting for 83% of the overall costs in 1989, 71% by 1992, and only 45% in 1995, while total outpatient's contribution was 14%, 26% and 49%. Before 1991 ebbing costs were likely related to the development of new technologies such as hematopoietic growth factors and peripheral SCT, while the three-fold larger improvement in costs reported by 1995 are presumably associated with learning curve effects such as organizational changes, increased use of coordinated outpatient facilities, and the more cost-effective use of laboratory tests and pharmaceuticals. Keywords: NHL; costs; transplant High-dose chemotherapy with autologous bone marrow or peripheral blood stem cell transplantation (SCT) has become the standard of care for many patients with relapsed Our earlier report from the University of Nebraska Medical Center (UNMC) indicated that costs of care for NHL patients decreased by 25% between 1987 and 1991, while the average inpatient stay decreased from 45 days to 38 days. 10 During this evaluation period, the use of hematopoietic colony-stimulating factors was a major reason for shortened periods of neutropenia, earlier discharge, and significant cost savings. More recent data on temporal changes in costs have not been reported, despite continued technological improvements and organizational changes (such as coordinated outpatient centers) for persons undergoing autologous SCT. The current study was undertaken to determine whether improvements in economic outcomes found during the first 5 years of the transplant program at UNMC persisted as the procedure continued to evolve and technological advances became more established. In addition, the possibility of cost shifting was of interest given the increased use of outpatient transplantation since 1991. As technological advances and organization changes facilitated earlier discharges and outpatient transp...