Physically-triggered nanosystems based on two-dimensional materials for cancer theranostics

Ji, Ding‐Kun; Ménard‐Moyon, Cécilia; Bianco, Alberto

doi:10.1016/j.addr.2018.08.010

Cited by 59 publications

(53 citation statements)

References 164 publications

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“…Currently, multiple combinations of various therapeutic and diagnostic modalities are adopted to achieve a theranostic effect (Orecchioni et al, 2015; Ji et al, 2019), and can be further improved and expanded thanks to the development of NM-based theranostic nanoplatforms. Among 2D NMs suitable for this purpose, graphene and graphene-based materials (GBMs), including few layer graphene (FLG), graphene oxide (GO), reduced graphene oxide (rGO), nano-graphene oxide (NGO), and graphene quantum dots (GQDs), bring the technological innovations needed to the current societal and industrial challenges (Boukhvalov and Katsnelson, 2008; Park and Ruoff, 2009; Gao et al, 2010; Kuila et al, 2012; Mao et al, 2012; James and Tour, 2013; Quintana et al, 2013; Yang et al, 2013a; Roppolo et al, 2014; Sechi et al, 2014; Servant et al, 2014; Kim et al, 2016; Shin et al, 2016; McManus et al, 2017; Park et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Photodynamic Therapy Based on Graphene and MXene in Cancer Theranostics

Gazzi

Fusco

Khan

et al. 2019

Front. Bioeng. Biotechnol.

110

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Cancer is one of the leading causes of death in the world. Therefore, the development of new advanced and targeted strategies in cancer research for early diagnosis and treatment has become essential to improve diagnosis outcomes and reduce therapy side effects. Graphene and more recently, MXene, are the main representatives of the family of two-dimensional (2D) materials and are widely studied as multimodal nanoplatforms for cancer diagnostics and treatment, in particular leveraging their potentialities as photodynamic therapeutic agents. Indeed, due to their irreplaceable physicochemical properties, they are virtuous allies for photodynamic therapy (PDT) in combination with bioimaging, photothermal therapy, as well as drug and gene delivery. In this review, the rapidly progressing literature related to the use of these promising 2D materials for cancer theranostics is described in detail, highlighting all their possible future advances in PDT.

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Section: Introductionmentioning

confidence: 99%

Photodynamic Therapy Based on Graphene and MXene in Cancer Theranostics

Gazzi

Fusco

Khan

et al. 2019

Front. Bioeng. Biotechnol.

110

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“…Graphene oxide (GO) has been extensively investigated in many fields, in particular in nanomedicine because of its excellent aqueous processability, amphiphilicity and the possibility of surface functionalization . In its reduced form, it displays thermal and electrical conductivity that can be exploited for the development of biosensors .…”

Section: Introductionmentioning

confidence: 99%

Strategies for the Controlled Covalent Double Functionalization of Graphene Oxide

Vacchi

Guo

Raya

et al. 2020

Chemistry A European J

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Graphene oxide (GO) is av ersatile platform with unique properties that have found broad applications in the biomedical field. Double functionalization is ak ey aspecti n the designo fmultifunctional GO with combined imaging, targeting, and therapeutic properties. Compared to noncovalent functionalization, covalents trategies lead to GO conjugates with ah igher stability in biological fluids. However, only af ew double covalentf unctionalization approaches have been developed so far.T he complexity of GO makes the derivatization of the oxygenated groups difficult to control. The combination of an ucleophilic epoxide ring opening with the derivatization of the hydroxyl groups through esterification or Williamson reaction was investigated. The conditions were selective and mild, thus preserving the structure of GO. Our strategy of double functionalization holds great potentialf or different applications in which the derivatization of GO with different molecules is needed, especiallyi nt he biomedical field.Supporting information and the ORCID identification number(s) for the author(s) of this articlecan be found under: https://doi.Scheme1.Double-functionalization approach combining the opening of the epoxides and the Williamson reaction (each reaction is showno nly on one functional group for clarity).Scheme2.Double functionalization of GO performedbyc ombining the epoxide opening with esterification on GO-A (each reaction is shownonly on one functional groupf or clarity).

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“…2D nanomaterials for drug delivery systems have been extensively studied due to their high specific surface area and unique surface chemistry functions. 64,65 The surface of BP is negatively charged and can bond with positively charge drugs. 66 Various functional biomolecules and nanoparticles can be adsorbed onto the surface of BP nanomaterials.…”

Section: Drug-loading Capacitymentioning

confidence: 99%

<p>Advanced Black Phosphorus Nanomaterials for Bone Regeneration</p>

Qing

et al. 2020

IJN

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Bone regeneration remains a great clinical challenge. Two-dimensional materials, especially graphene and its derivative graphene oxide, have been widely used for bone regeneration. Since its discovery in 2014, black phosphorus (BP) nanomaterials including BP nanosheets and BP quantum dots have attracted considerable scientific attention and are considered as prospective graphene substitutes. BP nanomaterials exhibit numerous advantages such as excellent optical and mechanical properties, electrical conductivity, excellent biocompatibility, and good biodegradation, all of which make them particularly attractive in biomedicine. In this review, we comprehensively summarize recent advances of BP-based nanomaterials in bone regeneration. The advantages are reviewed, the different synthesis methods of BP are summarized, and the applications to promote bone regeneration are highlighted. Finally, the existing challenges and perspectives of BP in bone regeneration are briefly discussed.

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Physically-triggered nanosystems based on two-dimensional materials for cancer theranostics

Cited by 59 publications

References 164 publications

Photodynamic Therapy Based on Graphene and MXene in Cancer Theranostics

Photodynamic Therapy Based on Graphene and MXene in Cancer Theranostics

Strategies for the Controlled Covalent Double Functionalization of Graphene Oxide

<p>Advanced Black Phosphorus Nanomaterials for Bone Regeneration</p>

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