Physically Cross-Linked Alkylacrylamide Hydrogels:  Phase Behavior and Microstructure

Tian, Jun; Seery, Thomas A. P.; Weiß, Robert

doi:10.1021/ma049475r

Cited by 45 publications

(75 citation statements)

References 62 publications

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“…The LCST of GrRD2N was markedly increased as predicted from the previous reports. 28,29 This can explain the previous finding that no change of contact angle was detected in the measurements at 20 C and 60 C. 21 Namely, the both temperatures for the measurement were lower than that of hydrophobic aggregation of GrRD2N.…”

Section: Thermoresponsive Behavior and Additional Property Of The Grasupporting

confidence: 64%

“…21 The component of poly(DMAA), which presents more hydrophilic environment compared to the poly(NIPAM), in the block copolymer may raise Lowest Critical Phase Separation Temperature (LCST) as shown in the random copolymer prepared from the same monomers. 28,29 While, no influence on the thermoresponsive behavior is observed on the gel containing the block copolymer of NIPAM. 30 The examination concerning the behavior of the block copolymer grafted PSQs, in which the hydrophilic environment should be changed by sequence and molecular weight of the polymeric components, was expected to give the information concerning the phenomenon of thermoresponsive phase separation caused by poly(NIPAM).…”

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confidence: 96%

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Preparation of Stimuli-responsive Polysilsesquioxane Grafted Block Copolymer of Acrylamide Monomers

Masuda

Yamamoto

Moriya

et al. 2007

Polym J

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The polysilsesquioxanes (PSQs) having the graft block copolymer of N-isopropylacrylamide (NIPAM) and N,Ndimethylacrylamide (DMAA), which showed the different sequence and number of the monomer units, were obtained by RAFT process. In addition, the PSQ derivatives containing other organic functional groups besides the grafted polymers were prepared by the use of chloromethylphenyl groups on the starting PSQ. Through the formation of ester bond and quarternary ammonium salt, phenol, triethylamine, and N,N-dimethylaniline groups were introduced into the grafted PSQ, respectively. In the behaviors of reversible thermoresponsive aggregation caused by poly(NIPAM) component, the almost same Lowest Critical Solution Temperature such as 34 C was observed for the grafted PSQs, although the poly(DMAA), phenol groups, and/or the quarternary ammonium salts were existed on the same PSQ backbone. As an additional function, the presence of phenol groups led to pH responsive solubility in water. The solubility of the PSQs in water was also affected by hydrophilic property of the amines to form the quarternary ammonium salts. In addition, a kind of chromism, which related with pH value, was observed in the case containing N,N-dimethylaniline moieties.KEY WORDS: Thermoresponsive Phase Separation / Polysilsesquioxane / N-Isopropylacrylamide / Chromism / Graft Polymerization / Recently, various investigations on oligomeric and polymeric silsesquioxanes, which stress on the modifications by various organic functional groups, have been presented from the interests in a useful hybrid material. [1][2][3][4][5][6][7][8][9] The graft polymerization from polysilsesquioxane backbone is shown as an effective procedure for the modifications. The methodology enables to provide the additional functions based on the polymeric components without loosing the essential properties of inorganic siloxane structure such as durability for heat and weatherability. [10][11][12][13][14][15][16] In the previous works, we also have investigated concerning the graft polymerizations from polysilsesquioxane backbone, which intended to develop the new multi-functional hybrid materials. [17][18][19][20][21] As an example of such graftings, the introduction of block copolymer of N,N-dimethylacrylamide (DMAA) and N-isopropylacrylamide (NIPAM) by the living polymerization technique, reversible addition-fragmentation chain transfer (RAFT) process, was reported. 21 In the graft polymerization, the PSQ having chloromethylphenyl groups (CPPSQ) was prepared from the corresponding trimethoxysilane and, then, N,N-dimethyldithiocarbamate (DTC) group was introduced as a chain transfer specie for RAFT process.The previous results demonstrated that the block copolymer grafted PSQs showed an expected amphiphilic property, where the solubility in water was influenced by the sequence and number of the monomer units in the grafted chain. 21 Namely, when the more hydrophilic poly(DMAA) was grafted from the polysilsesquioxane backbone at first and poly(NIPAM) was grafted after poly(...

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Section: Thermoresponsive Behavior and Additional Property Of The Grasupporting

confidence: 64%

mentioning

confidence: 96%

Preparation of Stimuli-responsive Polysilsesquioxane Grafted Block Copolymer of Acrylamide Monomers

Masuda

Yamamoto

Moriya

et al. 2007

Polym J

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“…As an alternative to alkyl side chains, fluorocarbon hydrophobes can also be used to prepare hydrogels based on hydrophobic interactions [265][266][267]. In water, fluorocarbon motifs display even stronger hydrophobic association than hydrogenated hydrophobes.…”

Section: Hydrophobic Interactionsmentioning

confidence: 99%

Supramolecular Polymer Networks: Preparation, Properties, and Potential

Rossow

Seiffert

2015

Advances in Polymer Science

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“…For example, physical gels of poly(N-isopropylacrylamide) are formed due to hydrophobic interactions between side groups. [251][252][253] During deformation of the material, hydrophobic interactions between side groups can be ''broken'' and then reformed between different combinations of polymer side groups. The interchangeable nature of the hydrophobic interactions can result in a viscous or viscoelastic gel.…”

Section: Physical Gelsmentioning

confidence: 99%

Injectable hydrogels

Overstreet

Dutta

Stabenfeldt

et al. 2012

J Polym Sci B Polym Phys

159

124

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Hydrogels are promising for a variety of medical applications due to their high water content and mechanical similarity to natural tissues. When made injectable, hydrogels can reduce the invasiveness of application, which in turn reduces surgical and recovery costs. Key schemes used to make hydrogels injectable include in situ formation due to physical and/or chemical cross-linking. Advances in polymer science have provided new injectable hydrogels for applications in drug delivery and tissue engineering. A number of these injectable hydrogel systems have reached the clinic and impact the health care of many patients. However, a significant remaining challenge is translating the ever-growing family of injectable hydrogels developed in laboratories around the world to the clinic. V C 2012 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 50: 2012

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Physically Cross-Linked Alkylacrylamide Hydrogels: Phase Behavior and Microstructure

Cited by 45 publications

References 62 publications

Preparation of Stimuli-responsive Polysilsesquioxane Grafted Block Copolymer of Acrylamide Monomers

Preparation of Stimuli-responsive Polysilsesquioxane Grafted Block Copolymer of Acrylamide Monomers

Supramolecular Polymer Networks: Preparation, Properties, and Potential

Injectable hydrogels

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