Physical urticaria: Clinical features, pathogenesis, diagnostic work-up, and management

McSweeney, Sheila M; Christou, Evangelos A.A.; Maurer, Marcus; Grattan, Clive; Tziotzios, Christos; McGrath, John A.

doi:10.1016/j.jaad.2023.02.062

Cited by 4 publications

(2 citation statements)

References 190 publications

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“…A positive test was indicated through the appearance of a localized wheal and flare reaction upon rewarming. The presence of solar urticaria was determined by observing urticaria episodes on the skin after exposure to sunlight or specific wavelengths of ultraviolet A and ultraviolet B [19,20].…”

Section: Diagnostic Physical Urticaria Provocation Testsmentioning

confidence: 99%

Evaluation of Pediatric Chronic Urticaria with Emphasis on Clinical and Laboratory Characteristics and Treatment Response to Omalizumab: A Real-Life Experience from a Tertiary Allergy Center

Özhan,

Arıkoğlu

2024

Children

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Pediatric data on the clinical and etiologic features, treatment response, and use of omalizumab for chronic urticaria (CU) are quite limited. The aim of this study was to evaluate the clinical and demographic characteristics, laboratory findings, and response to treatment of CU in children. Children with a diagnosis of CU between 2019 and 2023 were included in the study. Information on demographic characteristics, clinical features, laboratory tests, provocation tests for inducible urticaria, urticaria activity scores (UAS7), and treatment responses were obtained from patients’ medical records. A total of 150 children (50.7% male) with CU were enrolled in the study. A total of 14 (9.3%) patients had autoimmune diseases of which 11 (7.3%) had autoimmune thyroiditis. Overall, 97 (64.7%) patients had chronic spontaneous urticaria (CSU) and 53 (35.3%) had chronic inducible urticaria. A total of 16 patients who remained symptomatic despite high-dose antihistamines were treated with omalizumab, with a good response in 13 (81.3%) and a partial response in 3 (18.7%) patients. CSU accounts for the majority of pediatric CU, with the etiology being in part related to an autoimmune background. This study provides an overview of CU in children and demonstrates the safety and efficacy of treatment with omalizumab.

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Section: Diagnostic Physical Urticaria Provocation Testsmentioning

confidence: 99%

Evaluation of Pediatric Chronic Urticaria with Emphasis on Clinical and Laboratory Characteristics and Treatment Response to Omalizumab: A Real-Life Experience from a Tertiary Allergy Center

Özhan,

Arıkoğlu

2024

Children

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“…For this review, chronic urticaria is the more relevant grouping, which includes the category of chronic spontaneous urticaria and its two subtypes: autoallergic (type 1 autoimmunity, IgE auto-antibody presence) and autoimmune (type IIb autoimmunity, IgG auto-antibody presence) [ 10 ]. Another known category is chronic inducible urticaria (physical urticaria), which includes subcategories based on its triggers: mechanical (which includes friction, pressure, and vibration urticaria), thermal (including cold and heat urticaria), and solar electromagnetic radiation (Figure 3 ) [ 1 , 10 - 11 ]. Physical urticarial groupings can be alternatively broadly subdivided into common physical urticaria (including cholinergic, cold, delayed pressure, and dermatographism) and uncommon physical urticaria (including aquagenic, vibratory, solar, and adrenergic) (Figure 4 ) [ 1 ].…”

Section: Reviewmentioning

confidence: 99%

Adrenergic Urticaria: An Updated Review

Slater,

Abu-Zahra,

Kartono

2024

Cureus

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It can be difficult to delineate the cause of urticarial eruptions, and in chronic cases, it can be a challenging condition to effectively treat. Several forms of urticarial eruptions are well documented and established. Our review focuses on a form of urticaria that is less commonly reported: adrenergic urticaria. In this review, we aim to consolidate the literature in the hopes that this urticarial subtype is considered in urticarial differentials, as well as highlight potential gaps in the research and future directions in treatment options.

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