Physical training prior to myocardial infarction potentializes stem cell therapy, SDF-1/CXCR4 axis activation and inhibits the vasoconstrictor response in hypertensive rats

Objectives Cichorium intybus is used in traditional medicine for various diseases including heart disease. This study aimed at evaluating the chemokine receptor type 4 up-regulation and cardioprotective effects of hydroalcoholic extract of C. intybus in a rat model of ischemic reperfusion. Methods Animals in four groups of eight rats each received vehicle or one of three doses of C. intybus (50, 100 or 200 mg/kg/d) for 14 days. Then they were subjected to 30 min of ischemia followed by 7 days of reperfusion. At the end of the experiment, blood specimens were prepared for serum assays. The level of myocardium chemokine receptor type 4 was also measured using RT-PCR. Key findings Cichorium intybus (CI-50) improved infarct size, episodes of the ventricular ectopic beat, ventricular tachycardia, and duration of ventricular tachycardia, QTc shortening. It also stabilized the ST segment changes and increased heart rate during ischemia. The blood pressure decreased in CI-50 group in comparison to the control and CI-200 group. C. intybus increased serum superoxide dismutase and reduced lactate dehydrogenase activity, Cardiac Troponin I and malondialdehyde levels. C. intybus led to an increase in the expression of chemokine receptor type 4. Conclusions These findings suggest that C. intybus administration before ischemia is able to induce cardioprotective effect against ischemic reperfusion injury, probably through chemokine receptor type 4 over-expression and antioxidant activity.

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Bone Marrow Mesenchymal Stem Cell (BMSC) Ameliorates the Damage of Inflammatory Bowel Disease (IBD) Rats Through Regulation of Stromal Cell-Derived Factor 1/C-X-C Chemokine Receptor Type 4 (SDF-1/CXCR4) Axis

Kang

2022

j biomater tissue eng

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This study assesses the effect and mechanism of BMSC in IBD rat. Fifty SDF-grade rats were assigned into divided into NC group, model group, BMSC group, blocking agent group and positive NC group randomly with 10 rates in each group. The histopathological changes of colon tissue, expression of Musashi-1, DAPI, SDF-1 and CXCR4 was measured. There was notable inflammatory cell infiltration in model group and agonist group. The structure of gland was destructed notably with notable-visible phenomenon of hyperemia and edema in colon tissue. They could be improved significantly in positive control group and BMSC group. The necrotic colonic mucosal tissue began to be recovered slowly. The phenomenon of hyperemia and edema was alleviated notably without abnormality in colon tissue in control group. The positive level of Musashi-1 in control group, model group and agonist group was the highest. In conclusion, BMSC could be migrated into colonic damage position and differentiated into intestine stem cells to exert recovery effect on IBD rats. The molecular mechanism might be related with SDF-1/CXCR4 axis.

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Physical training prior to myocardial infarction potentializes stem cell therapy, SDF-1/CXCR4 axis activation and inhibits the vasoconstrictor response in hypertensive rats

Cited by 4 publications

References 34 publications

The Effect of Exercise on Mesenchymal Stem Cells and their Application in Obesity Treatment

The Effect of Exercise on Mesenchymal Stem Cells and their Application in Obesity Treatment

Up-regulation of chemokine receptor type 4 expression in the ischemic reperfused heart by alcoholic extract of Cichorium intybus rescue the heart from ischemia injury in male rat

Bone Marrow Mesenchymal Stem Cell (BMSC) Ameliorates the Damage of Inflammatory Bowel Disease (IBD) Rats Through Regulation of Stromal Cell-Derived Factor 1/C-X-C Chemokine Receptor Type 4 (SDF-1/CXCR4) Axis

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