Physical training prevent and treat hepatic lipid accumulation induced by fructose-rich diet

Abstract

ABSTRACT:This study aims to examine the effects of physical training performed in early (preventive) or late (therapeutic) protocols on body weight gain, glucose tolerance, and triglycerides accumulation in rats fed on a fructoserich diet. Wistar rats were allocated into two major groups according to the diet received: Control (C-standard diet) and Fructose (F-diet containing 60% fructose) fed during 120 days. Next, these two groups were distributed into six groups: C and F that were kept inactive; CTE (Control Trained Early) and FTE (Fructose Trained Early) that were submitted to Anaerobic Threshold (AnT) training from 28 to 120 days; CTL (Control Trained Late) and FTL (Fructose Trained Late) trained from 90 to 120 days. Physical Training was composed by swimming (5 days/week) at AnT determined by maximum lactate stead state (MLSS). The Oral Glucose Tolerance Test (oGTT) was performed 48h after the last in vivo analysis and did not showed differences between the groups. After, the animals were euthanized for heart, liver, and adipose tissue extraction. The early exercised animals had lower body weight compared to their sedentary littermates. Also, the fructose-rich diet increased liver lipids content in the sedentary animals and physical training successfully reduced this parameter in both major groups. These results suggests that physical training at the AnT performed in early or late protocols are effective to prevent and treat metabolic disorders related to fructose intake.

What Is the Effect of Physical Exercise on Nafld/Nash

“…Two interesting questions are how does exercise benefit NAFLD and what is/are the mediators of the muscle-liver axis whereby the muscle regulates hepatic metabolism. However, considering the scarcity of studies that suggest a definite and precise answer to these questions, further research is needed in order to widen knowledge into the mechanisms through which physical exercise has a positive impact on NASH patients´ life quality [25,34,38].…”

Efeitos do exercício físico sobre a via de sinalização da proteína ROCK e regulação da lipogênese e gliconeogênese no fígado de ratos envelhecidos

“…De maneira importante, através de mapeamento por radioisótopos, é possível observar não só a diminuição da massa do fígado, assim como a perda da funcionalidade das células hepáticas (34). Além disso, o aumento do estresse oxidativo, aumento da inflamação, a senescência celular acelerada, a disfunção mitocondrial, e a diminuição na capacidade de reparo do tecidual, se tornam fatores importantes no agravo de doenças relacionadas ao tecido hepático em idades avançadas (35)(36)(37)(38)(39). O conjunto destes fatores leva o tecido hepático ao desenvolvimento de fibrose, podendo avançar para o estado mais crítico de cirrose e carcinoma hepatocelular.…”