Physical training and multiple sclerosis

Gallien, P.; Nicolas, B.; Duruflé, A.; Robineau, S.; Pétrilli, S.; Autret, K.; Houedakor, J.; Meur, C. Le

doi:10.1016/j.rehab.2012.07.518

Cited by 4 publications

(3 citation statements)

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“…Contrary to earlier fears that physical activity could lead to relapse and faster progression of the disease recent studies have shown that exercise does not endanger health and that regular training raises physical fitness, reduces fatigue and can thus lead to considerable improvement in the QoL of the patients (Gallien et al, 2007;Mostert & Kesselring, 2002;Petajan et al, 1996). In comparison to the normal population, however, patients with MS undertake less sporting activity (Tallner et al, 2012).…”

Section: Introductionmentioning

confidence: 96%

Physical capacity and quality of life in patients with multiple sclerosis

Kerling

Keweloh

Tegtbur

et al. 2014

NRE

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BACKGROUND: Physical capacity (PC) and quality of life (QoL) are both reduced in multiple sclerosis (MS). OBJECTIVE: Aim of our study was to investigate limitations in PC and QoL in response to the severity of MS. METHODS:The study involved 60 patients (PG) (Expanded Disability Status Scale EDSS 0-3:38, EDSS 3.5-6:22) and 48 healthy controls (CG). Endurance capacity was assessed as peak oxygen uptake (VO 2peak ) and ventilatory anaerobic threshold (VAT). Maximum force was measured in isokinetic testing. QoL was assessed using the SF-36-questionnaire and HALEMS. RESULTS: Patients with MS showed reduced VO 2peak and QoL in comparison with CG. Patients with an EDSS >3 showed reduced VO 2peak , and maximum force, however at the VAT there was no significant difference independent of the EDSS. The MS-specific QoL HALEMS and subscales 1, 4, 6, 8 and the physical sum score of the SF-36-questionnaire were evaluated to be better in patients with an EDSS ≤3. CONCLUSIONS: There are limitations within PC in patients with MS in comparison with a healthy CG; within the PG there are notes on a similar aerobic capacity but worsened anaerobic capacity in patients with an EDSS >3. This should be taken into account in future treatment strategies for training therapy.

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Section: Introductionmentioning

confidence: 96%

Physical capacity and quality of life in patients with multiple sclerosis

Kerling

Keweloh

Tegtbur

et al. 2014

NRE

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“…MS usually occurs between the ages of 18-50 [21]. MS patients have limited physical activity due to the risk of relapse [21][22][23]. Although the pathogenesis of MS has not been elucidated entirely, genetic and environmental factors are collectively effective in the pathogenesis.…”

Section: Discussionmentioning

confidence: 99%

Could NCOA5 a novel candidate gene for multiple sclerosis susceptibility?

Rustemoglu,

Arslan,

Atasever

et al. 2023

Mol Biol Rep

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BackgroundMultiple sclerosis (MS) is an in ammatory immune-mediated demyelinating disease which characterized a challenging and disabling condition. It is known that environmental and genetic factors play a role in directing the disease state. Recent studies have shown that nuclear cofactor genes may play a role in the MS pathogenesis. NCOA5 is a nuclear receptor coactivator independent of AF2 that modulate ERamediated transcription. NCOA5 gene is also involved in the pathogenesis of various diseases such as psoriasis, Behçet's disease and cancer. Methods and ResultsWe were investigated the relationship between the NCOA5 gene rs2903908 polymorphism and MS disease on 157 unrelated MS patients and 160 healthy controls by RT-PCR. The frequency of CC, CT, and TT genotypes was 19.87%, 37.82%, and 42.31% for the MS group while 5.63%, 43.75%, and 50.62% control group, respectively. In the obtained results, CC genotype and C allele were found to be signi cantly higher in the patient group (p = 0.0002 and 0.003, respectively). In particular, the fact that the CC genotype was found to be signi cantly higher in the patient group compared to the control group (p = 0.0002) and that it had a statistically signi cantly higher OR value (OR,95%CI = 4.16, suggests that the C allele may recessively predispose to the MS disease for this polymorphism. ConclusionsThese results suggest for the rst time in the literature that, the NCOA5 gene may have an effect on the occurrence MS disease through different molecular pathways which discussed in the manuscript.

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“…Troubles de l'adaptation à l'effort [32][33][34][35] Différentes études ont montré une capacité aérobie plus faible chez les sujets atteints de SEP avec une consommation maximale d'oxygène (VO2 max), diminuée lors des épreuves d'effort, en lien pour partie à des facteurs périphériques comme la faiblesse musculaire ou la fatigue. Une atteinte pulmonaire peut altérer l'adaptation à l'effort en rapport avec une altération de la commande des muscles respiratoires.…”

Section: Troubles Vésicosphinctériens Et Sexuelsunclassified