Physical Properties of Gum Karaya-Starch-Essential Oil Patches

Shcherbina, Yulia; Roth, Zvi; Nussinovitch, A.

doi:10.1208/s12249-010-9502-0

Cited by 8 publications

(4 citation statements)

References 29 publications

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“…It might be highlighted that both components of the scaffold described here, PVA and KG, are biocompatible and biodegradable . PVA is more stiff and tough in comparison to KG . This finding is corroborated by our studies revealing that an increased KG content of the cryogel decreased the Young's modulus.…”

Section: Discussionsupporting

confidence: 86%

In Situ Polyphosphate Nanoparticle Formation in Hybrid Poly(vinyl alcohol)/Karaya Gum Hydrogels: A Porous Scaffold Inducing Infiltration of Mesenchymal Stem Cells

et al. 2018

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The preparation and characterization of a porous hybrid cryogel based on the two organic polymers, poly(vinyl alcohol) (PVA) and karaya gum (KG), into which polyphosphate (polyP) nanoparticles have been incorporated, are described. The PVA/KG cryogel is prepared by intermolecular cross‐linking of PVA via freeze‐thawing and Ca2+‐mediated ionic gelation of KG to form stable salt bridges. The incorporation of polyP as amorphous nanoparticles with Ca2+ ions (Ca‐polyP‐NP) is achieved using an in situ approach. The polyP constituent does not significantly affect the viscoelastic properties of the PVA/KG cryogel that are comparable to natural soft tissue. The exposure of the Ca‐polyP‐NP within the cryogel to medium/serum allows the formation of a biologically active polyP coacervate/protein matrix that stimulates the growth of human mesenchymal stem cells in vitro and provides the cells a suitable matrix for infiltration superior to the polyP‐free cryogel. In vivo biocompatibility studies in rats reveal that already two to four weeks after implantation into muscle, the implant regions containing the polyP‐KG/PVA material become replaced by initial granulation tissue, whereas the controls are free of any cells. It is proposed that the polyP‐KG/PVA cryogel has the potential to become a promising implant material for soft tissue engineering/repair.

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Section: Discussionsupporting

confidence: 86%

In Situ Polyphosphate Nanoparticle Formation in Hybrid Poly(vinyl alcohol)/Karaya Gum Hydrogels: A Porous Scaffold Inducing Infiltration of Mesenchymal Stem Cells

et al. 2018

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“…Gum karaya-essential oil patches with or without starch were produced as previously described by Cherebina et al [19]. Briefly, the first fraction was composed of 13.6 to 23.6% (w/w) distilled water, 21.1% (w/w) glycerol (Sigma Chemical Co., St. Louis, MO), 7.5% (w/w) of either Lavandula angustifolia essential oil ("Light of the Desert", Kibbutz Urim, Israel) or Valencia orange oil (Kibbutz Givat Haim, Israel), 1% (w/w) Tween 80 (Sigma) as an emulsifier and, optionally, 10% (w/w) potato starch (Merck, Darmstadt, Germany) as a filler.…”

Section: Patch Preparationmentioning

confidence: 99%

“…We have recently produced essential-oil patches, in which Lavandula angustifolia a concentration of 2.5 to 10% was included. The patches are manufactured from the exudate Gumkaraya, propylene glycol, glycerol, emulsifier and optionally, potato starch as filler [19]. We found that inclusion of essential oil reduced to some extent the mechanical properties and adhesion of the patches however, a high proportion of essential oil could be included without losing patch integrity or eliminating its adhesiveness to the skin [19].…”

Section: Introductionmentioning

confidence: 97%

Transdermal Delivery of Lavandula angustifolia and Valencia Orange Essential Oils Using Gum-karaya Patches

Rotha¹,

Shcherbinab²,

Nussinovitchb³

2017

Med Aromat Plants

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Use of skin patches is an innovative, practical and promising approach for transdermal medicine delivery. Two sets of experiments were performed using a Franz diffusion cell [FC] apparatus and an animal model to study the passage of the essential oils of Lavandula angustifolia and Valencia orange from a gum-karaya hydrocolloid patch through the skin. Findings from the FC model revealed steady-state fluxes from the patch to the medium of 1.9 × 10 -4 mg . cm -2 h -1 for d-limonene, a component of orange essential oil, and 0.018 and 4.3 × 10 -4 mg . cm -2 h -1 for the lavender components linalool and camphor, respectively. When a lavender and almond oil mixture was applied by rubbing into the skin, 0.027 and 5.7 × 10 -4 mg . cm -2 h -1 were calculated for linalool and camphor, respectively. In the in-vivo part of the study, we examined the diffusion of essential oil from the patch and its components' penetration through a rat's skin into its circulation. Findings indicated better transfer when patches containing essential oil were adhered to the abdomen rather than the back skin of the animal. Some of the essential oil components were entrapped in the skin, resulting in differential penetration into the blood. We therefore suggest that a specific essential oil should be considered a mixture of ingredients rather one component. Moreover, the transfer and penetration from the patch through the skin to the blood seems to be multifactorial in nature. While some factors are associated with the essential oils' features, others are associated with the patch topography and physical or chemical properties. Taken together, the current study extends our understanding of the pattern of essential oil passage through the skin and explores the potential of essential oil patches for commercial use.

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“…In cosmetics, it has been used in hair dressing lotions and finger wave lotions [17]. Gum karaya has also been employed to produce essential-oil-intact patches of Lavandula angustifolia oil for aroma-therapeutic applications, essential oil delivery through the skin and other tropical applications [18].…”

Section: Introductionmentioning

confidence: 99%

Drying Kinetics of Gum Karaya (Sterculia urens) Using Convective Air Dryer

Singh

2014

BJPR

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The present study was aimed to investigate the drying kinetics of gum karaya (S. urens). Three grades of gum (I, II, III) were dried using a cabinet-type convective dryer. Particle size equivalent to US Sieve size-6 and air temperatures of 50, 60 and 70°C were used for the drying experiments. The experimental drying data was fitted to Page's model to predict the drying kinetics. Investigations with constant air velocity revealed that for grade-I gum, drying rate constant (k) varied between 0.2744-0.3742 (h -1 ), for grade-II gum between 0.3208-0.4439 (h -1 ) and for grade-III gum between 0.4098-0.4639 (h -1 ). The dimensionless number (n) was always more than 1 and minimum value of the Coefficient of determination (R 2 ) was 0.967. Increase in air temperature enhanced drying process and drying rate. For each particular temperature, the values of drying rate constant were minimum for grade-I, maximum for grade-III and intermediate for grade-II gum.

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Physical Properties of Gum Karaya-Starch-Essential Oil Patches

Cited by 8 publications

References 29 publications

In Situ Polyphosphate Nanoparticle Formation in Hybrid Poly(vinyl alcohol)/Karaya Gum Hydrogels: A Porous Scaffold Inducing Infiltration of Mesenchymal Stem Cells

In Situ Polyphosphate Nanoparticle Formation in Hybrid Poly(vinyl alcohol)/Karaya Gum Hydrogels: A Porous Scaffold Inducing Infiltration of Mesenchymal Stem Cells

Transdermal Delivery of Lavandula angustifolia and Valencia Orange Essential Oils Using Gum-karaya Patches

Drying Kinetics of Gum Karaya (Sterculia urens) Using Convective Air Dryer

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