Physical Properties of Aqueous N-Methyl Pyrrolidone at Different Temperatures

Maloka, Iamir E.; Ibrahim, Sabah Yassin

doi:10.1081/lpet-200027883

Cited by 7 publications

(8 citation statements)

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“…The shape of the profile is similar to that of the EtOH-Water mixtures (18). This observation is consistent with the reported lowering of the dielectric constant (reflecting reduction in the polarizability) of water with an increasing concentration of NMP (19).…”

Section: Additional Support For the Proposed Modelsupporting

confidence: 82%

Solubility Improvement of Drugs using N-Methyl Pyrrolidone

Narazaki²,

et al. 2008

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Abstract. The solubilization efficiency of N-methyl pyrrolidone (NMP) has been determined and compared to that of ethanol and propylene glycol for 13 poorly soluble drugs. NMP is found to be a more efficient solubilizer for all the drugs studied. The solubility enhancement as high as about 800-fold is obtained in 20% v/v NMP solution as compared to water. The mechanism of drug solubilization by NMP has also been investigated. It is proposed that NMP enhances drug solubility by simultaneously acting as a cosolvent and a complexing agent. A mathematical model is used to estimate the drug solubility in NMP-water mixture, according to which the total solubility enhancement is a sum of the two effects. This model describes the experimental data well and is more accurate than other models. A large and uniform reduction in the surface tension of water as a function of NMP concentration demonstrates its cosolvent effect. The complexation is supported by the fact that it's strength is affected by the temperature and the polarity of the medium. A strong correlation exists between log K ow of the drugs and the cosolvency coefficients. The correlation between log K ow and the complexation coefficients is weak suggesting that factors such as molecular shape and aromaticity of the drug molecule are significant in determining the complexation strength. This has been confirmed by the absence of a significant complexation between NMP and linear drug-like solutes.

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Section: Additional Support For the Proposed Modelsupporting

confidence: 82%

Solubility Improvement of Drugs using N-Methyl Pyrrolidone

Narazaki²,

et al. 2008

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“…Based on these observations, we propose that water molecules present in the atmosphere sequester the Lewis base DMSO/DMF/NMP from the adduct, which causes heterogeneity during nucleation and crystal growth and eventually leads to anisotropic crystal growth. This mechanism is likely because water has stronger bond affinity to DMF, DMSO, and NMP, respectively, than to itself, resulting in a complex formation . As perovskite structure is held together by weak hydrogen bonding, even weaker bonding is to be expected in the metastable adduct phase, which would make the Lewis bases highly labile to sequestering by water .…”

Section: Resultsmentioning

confidence: 99%

Controlling Homogenous Spherulitic Crystallization for High‐Efficiency Planar Perovskite Solar Cells Fabricated under Ambient High‐Humidity Conditions

Angmo

Peng

Seeber

et al. 2019

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The influence of precursor solution properties, fabrication environment, and antisolvent properties on the microstructural evolution of perovskite films is reported. First, the impact of fabrication environment on the morphology of methyl ammonium lead iodide (MAPbI3) perovskite films with various Lewis‐base additives is reported. Second, the influence of antisolvent properties on perovskite film microstructure is investigated using antisolvents ranging from nonpolar heptane to highly polar water. This study shows an ambient environment that accelerates crystal growth at the expense of nucleation and introduces anisotropies in crystal morphology. The use of antisolvents enhances nucleation but also influences ambient moisture interaction with the precursor solution, resulting in different crystal morphology (shape, size, dispersity) in different antisolvents. Crystal morphology, in turn, dictates film quality. A homogenous spherulitic crystallization results in pinhole‐free films with similar microstructure irrespective of processing environment. This study further demonstrates propyl acetate, an environmentally benign antisolvent, which can induce spherulitic crystallization under ambient environment (52% relative humidity, 25 °C). With this, planar perovskite solar cells with ≈17.78% stabilized power conversion efficiency are achieved. Finally, a simple precipitation test and in situ crystallization imaging under an optical microscope that can enable a facile a priori screening of antisolvents is shown.

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“…Most of them were collected from the open literature [5][6][7], while DMEPEG viscosity and surface tension of the three solvents were independently measured. DMEPEG viscosity was measured with a CVO 120 rheometer (Bohlin Instruments).…”

Section: Calculation Methodsmentioning

confidence: 99%

“…References to the problems under consideration. To date, there are no studies in the literature on the character and the rate of gas desorption from different organic solvents used in commercial applications with the exception of preliminary measurements of CO 2 +NMP and CO 2 +DMEPEG systems reported by Kierzkowska-Pawlak [5,6]. In the References cited, the measurements were performed for a single temperature of 293.15 K and no quantative description of the mass transfer rate was presented.…”

Section: Introductionmentioning

confidence: 95%

Carbon Dioxide Desorption from Saturated Organic Solvents

Kierzkowska‐Pawlak

Chacuk

2009

Chem Eng & Technol

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Carbon dioxide removal from various gaseous streams and its subsequent recovery are of considerable industrial importance. The absorption technologies represent the most important operation to separate CO 2 . In this work, the mass transfer rates during CO 2 absorption and desorption from propylene carbonate dimethyl ether of polyethylene glycol, and N-methyl-2-pyrrolidone solutions were measured over the temperature range of 293.15-323.15 K in a baffled agitated reactor with a flat gas-liquid interface operated in a batchwise manner. Two distinct mechanisms of desorption were observed: bubbling and diffusive desorption. The volumetric gas-liquid mass transfer coefficients for the bubbling desorption were determined from the measured overall and diffusive desorption rates, and were correlated by the semi-empirical equation. The proposed correlation is a power relationship of supersaturation, Reynolds and Weber numbers, and was found to quantitatively explain the observed phenomena with satisfactory agreement.

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Physical Properties of Aqueous N-Methyl Pyrrolidone at Different Temperatures

Cited by 7 publications

References 0 publications

Solubility Improvement of Drugs using N-Methyl Pyrrolidone

Solubility Improvement of Drugs using N-Methyl Pyrrolidone

Controlling Homogenous Spherulitic Crystallization for High‐Efficiency Planar Perovskite Solar Cells Fabricated under Ambient High‐Humidity Conditions

Carbon Dioxide Desorption from Saturated Organic Solvents

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