We report the spectroscopic confirmation of a new protocluster in the COSMOS field at z ∼ 2.2, COSMOS Cluster 2.2 (CC2.2), originally identified as an overdensity of narrow-band selected Hα emitting candidates. With only two masks of Keck/MOSFIRE near-IR spectroscopy in both H (∼ 1.47-1.81 µm) and K (∼ 1.92-2.40 µm) bands (∼ 1.5 hour each), we confirm 35 unique protocluster members with at least two emission lines detected with S/N > 3. Combined with 12 extra members from the zCOSMOS-deep spectroscopic survey (47 in total), we estimate a mean redshift and a line-ofsight velocity dispersion of z mean =2.23224 ± 0.00101 and σ los =645 ± 69 km s −1 for this protocluster, respectively. Assuming virialization and spherical symmetry for the system, we estimate a total mass of M vir ∼ (1 − 2)×10 14 M ⊙ for the structure. We evaluate a number density enhancement of δ g ∼ 7 for this system and we argue that the structure is likely not fully virialized at z ∼ 2.2. However, in a spherical collapse model, δ g is expected to grow to a linear matter enhancement of ∼ 1.9 by z=0, exceeding the collapse threshold of 1.69, and leading to a fully collapsed and virialized Coma-type structure with a total mass of M dyn (z=0) ∼ 9.2×10 14 M ⊙ by now. This observationally efficient confirmation suggests that large narrow-band emission-line galaxy surveys, when combined with ancillary photometric data, can be used to effectively trace the large-scale structure and protoclusters at a time when they are mostly dominated by star-forming galaxies.