Physical properties and structure of bound water in collagen-type fibrillar proteins as studied by scanning calorimetry

Габуда, С. П.; Gaidash, A. A.; Drebushchak, V. A.; Kozlova, S. G.

doi:10.1134/1.2161292

Cited by 12 publications

(6 citation statements)

References 3 publications

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“…In other words, the hydrophobic compartment (general part of a D period) and the hydrophilic compartment (friable part of D periods) can be separated in the structure of collagen fibrils of healthy rats. This confirms the previously discovered bimodal distribution of water in collagen interfaces [ 5 , 6 ].…”

Section: Resultssupporting

confidence: 92%

Nanoporous Structure of Bone Matrix at Osteoporosis from Data of Atomic Force Microscopy and IR Spectroscopy

Gaidash

Sinit︠s︡a

Babenko

et al. 2011

Journal of Osteoporosis

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It was found that in an osteoporotic bone the fraction of nanosized pores decreases, the mineral phase amorphizes, hydrated shells around mineralized particles of the bone matrix thicken, and adhesion forces increase. This contributes to the formation of water clusters similar to bulk water clusters compared to the healthy bone tissue and leads to the accumulation of more viscous liquid with increased intermolecular interaction forces in the pores of the bone matrix. Given this, the rates of chemical reactions proceeding in the water phase of ultrathin channels of general parts of collagen fibrils decrease. Ultimately, nanopores of collagen-apatite interfaces lose, to a certain extent, the capability of catalyzing the hydroxyapatite crystallization.

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Section: Resultssupporting

confidence: 92%

Nanoporous Structure of Bone Matrix at Osteoporosis from Data of Atomic Force Microscopy and IR Spectroscopy

Gaidash

Sinit︠s︡a

Babenko

et al. 2011

Journal of Osteoporosis

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“…As further investigations have shown, model (4) with regard to (21) was supported in [75][76][77], where it was shown that the structure of one part of bound water in disordered regions of the collagen protein structure belongs to the tectohydrate type, involving a continuous three-dimensional framework of water molecules with a tetrahedral coordination characteristic of ice and clathrate hydrates (Fig. 7).…”

Section: Hydrate Shells Of Collagen Type Proteinsmentioning

confidence: 77%

“…2 shows the NMR spectra of polycrystalline samples containing diffusing water molecules. Expressions (4)- (17) were used in the works of S. P. Gabuda and his colleagues in the studies of the structural location features, mechanisms of the internal mobility of molecules and their interactions in ionic and molecular crystals [19][20][21][22][23][24][25][26][27][28][29][30][31][32], in minerals , at phase transformations in crystals [58][59][60][61][62][63][64][65][66][67][68][69], and also hydrated proteins [70][71][72][73][74][75][76][77][78] and catalysts [79][80][81]. It is worth noting that formulas (4)-(17) can be used not only for the analysis of the diffusion mobility of water molecules and also for some other molecules characterized by pronounced intramolecular dipole-dipole interactions of nuclear magnetic moments forming doublet splittings.…”

mentioning

confidence: 99%

Gabuda’s model of averaging local magnetic fields in solid-state NMR. The mobility of atoms and molecules

Kozlova¹,

Sergeev²,

Бузник³

2016

J Struct Chem

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The review presents the main results of the studies of Prof. S. P. Gabuda, which were devoted to the NMR investigation of the mobility of atoms and molecules. The basic principles of his model for averaging local magnetic fields under the conditions of atomic and molecular mobility are outlined. This model provides a relationship between the parameters of these fields with the structural features of the mobility of atoms and molecules and intermolecular interactions. Ionic and molecular crystals, zeolites, molecular sieves, hydrated proteins, and so on are considered. Phase transitions in guest subsystems, effects of dynamic disordering and correlated electron motion on the mobility of atoms and molecules and their location are discussed.

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“…Space between macromolecules is populated by H 2 O(1) (points). Cisterns (or tanks) in collagen of skin and tendon are filled by nearly free water, H 2 O(2) (points) [1]. In the bone tissue the cisterns are filled by nanoparticles (nanocrystals, Fig.…”

Section: Resultsmentioning

confidence: 99%

Production of nanocrystalline hydroxyapatite on collagen template during in vivo tooth and bone regeneration with use of collagen-Ca-phosphate preparations

Litvinov¹,

Габуда

2008

2008 IEEE Region 8 International Conference on Computational Technologies in Electrical and Electronics Engineering

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Hydroxyapatite (hydroxyfluorapatite) -collagen and composite materials are synthesized using directed diffusion of ions from solutions on collagen fibers. Computer tomography indicates that the salt component is rather uniformly distributed over the organic matrix. According to the electron microscopic data,the composite materials involve salt nanocrystals (less than 1m in size), which are uniformly distributed between collagen fibers. Biotransformation of material was studied after its implantation to different defects of bones of experimental animals. Nanocrystals of apatite plays a role of some catalytic agent accelerating the regeneration process in studied bone, tooth tissues and parenchymatous organs.

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Physical properties and structure of bound water in collagen-type fibrillar proteins as studied by scanning calorimetry

Cited by 12 publications

References 3 publications

Nanoporous Structure of Bone Matrix at Osteoporosis from Data of Atomic Force Microscopy and IR Spectroscopy

Nanoporous Structure of Bone Matrix at Osteoporosis from Data of Atomic Force Microscopy and IR Spectroscopy

Gabuda’s model of averaging local magnetic fields in solid-state NMR. The mobility of atoms and molecules

Production of nanocrystalline hydroxyapatite on collagen template during in vivo tooth and bone regeneration with use of collagen-Ca-phosphate preparations

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