Physical performance in long-term survivors of acute leukaemia in childhood

Black, Peter C.; Gutjahr, P.; Stopfkuchen, H.

doi:10.1007/s004310050854

Cited by 22 publications

(13 citation statements)

References 25 publications

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“…The study by Matthys et al 13 was excluded because they included in the same group ALL survivors and childhood survivors of several types of cancer other than ALL. The studies from Ostanski et al, 15 Black et al, 16 Kadota et al, 17 Lipshultz et al, 18 Pihkala et al, 19 Calzolari et al 20 Turner-Gomez et al, 21 and Zalewska-Szewczyk et al 22 were excluded from the meta-analysis, because of missing or incomplete description of the methodology (gas analysis) for VO 2peak measurement. The study by Prestor et al 23 A total of 102 childhood survivors of ALL and 99 control subjects from three studies were included in this review (Table 2).…”

Section: Resultsmentioning

confidence: 99%

“…Particularly, female patients show a greater impairment after treatment with anthracyclines, which results in further deterioration of functional capacity and increased body fat compared to males. 13,14,16 For instance, Matthys et al estimated the physical activity of ALL survivors with a questionnaire. Sport leisure time was lower in girl survivors of cancer (the majority, but not all, of which was ALL) than in their corresponding controls.…”

Section: Discussionmentioning

confidence: 99%

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Is physical fitness decreased in survivors of childhood leukemia? A systematic review

et al. 2004

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The aim of this review is to determine whether physical fitness, assessed by peak oxygen uptake (VO 2peak ) measurement, is reduced in survivors of acute lymphoblastic leukemia (ALL) compared to healthy children. A systematic literature search (up to June 2004) was performed using Medline, Sportdiscus, Cinahl, Embase, Cochrane and PEDro database and reference tracking. The VO 2peak (ml kg À1 min À1 ) reached during a maximal exercise test until volitional exhaustion was used as the main outcome for this review. In all, 17 studies were identified in the literature. Data from three studies (102 ALL survivors, age ranging from 7 to 19 years) were pooled in a meta-analysis. Although there was a significant heterogeneity between the included studies (P ¼ 0.0006), the standardized mean difference (SMD) value of À0.61 (P ¼ 0.07) indicated that VO 2peak tended to be reduced in survivors of childhood ALL compared to healthy control subjects, that is, decrease of À5.97 ml kg À1 min À1 (95% confidence interval (CI): (À12.35, 0.41); P ¼ 0.07) or À13% (95 % CI: (À27, 0.004)). Physical fitness tends to be reduced in survivors of ALL during childhood, which suggests the need for this population group to engage in regular physical activities with the purpose of increasing their functional capacity. Although more research is needed, this functional improvement might ameliorate the quality of life of ALL survivors as physical and outdoors activities are an essential part of daily routine during childhood.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Is physical fitness decreased in survivors of childhood leukemia? A systematic review

et al. 2004

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“…Given that ALL survivors are at higher risk than the general population for several modifiable health problems, the importance of participating in regular physical activity is even greater for this group. Six cross-sectional studies assessing 220 leukemia survivors in their childhood and adolescent years have reported a mild to moderate reduction in exercise capacity and habitual physical activity levels (21)(22)(23)(24)(25)(26). How these changes extend into adulthood is not known.…”

Section: Introductionmentioning

confidence: 99%

Physical Inactivity in Adult Survivors of Childhood Acute Lymphoblastic Leukemia: A Report from the Childhood Cancer Survivor Study

Florin

Fryer

Miyoshi

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

190

160

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“…In the current study, however, we did not see a difference in maximal exercise parameters between pediatric patients and survivors. We previously found a normal cardiopulmonary capacity in 42 of 56 (75%) pediatric and adult long-term survivors undergoing spiroergometric testing 17 years after treatment for ALL [2]. We surmised at that time, in contrast to Odame et al [16], that the decreased fitness may be related to sedentary lifestyle and potential obesity of cancer survivors, rather than the obesity being a result of decreased exercise capacity.…”

Section: Discussionmentioning

confidence: 81%

“…This hypothesis was based on previous reports of a high prevalence of subclinical and clinically evident cardiotoxicity after anthracycline treatment [2,8,11,21,25]. Side effects of anthracyclines can be divided into acute or late toxicity.…”

Section: Discussionmentioning

confidence: 98%

Recovery kinetics of heart rate and oxygen uptake in long-term survivors of acute leukemia in childhood

et al. 2007

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Analysis of the recovery period following physical exercise has gained importance in evaluating cardiopulmonary capacity, not only in athletes but also in patients with proven or suspected heart failure. The purpose of this study was to apply these methods to long-term survivors of acute lymphoblastic leukemia (ALL) in childhood, who are at risk of developing anthracycline-induced cardiomyopathy. Nine children (mean age 12 years) and 10 adults (mean age 24 years) were included in the study after treatment for childhood ALL. Recovery of oxygen uptake and heart rate following maximal spiroergometric exercise was compared to that in 29 trained and untrained age-matched controls. The change in oxygen uptake (DeltaVO2) and heart rate (DeltaHR) between maximal effort and 60 s of recovery did not differ significantly, either between children after oncological therapy (DeltaVO2: 14.95 ml/kg, DeltaHR: 35 bpm) and healthy children (DeltaVO2: 15.85 ml/kg, DeltaHR: 37 bpm), or between adult former oncological patients (DeltaVO2: 13.1 ml/kg, DeltaHR: 27 bpm) and untrained adults (DeltaVO2: 15.7 ml/kg, DeltaHR: 31 bpm). There was, however, a significant difference in DeltaVO2 between trained adults (DeltaVO2: 24.5 ml/kg) and both untrained adult controls (DeltaVO2: 15.7 ml/kg, p=0.004) and adult patients (DeltaVO2: 13.1 ml/kg, p=0.0002). This difference was not detected for heart rate. In conclusion, the recovery period did not reveal a discernible difference in cardiopulmonary capacity between former ALL patients and untrained age-matched controls. We did confirm that heart rate and oxygen uptake recovery serve as indicators of physical fitness.

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Physical performance in long-term survivors of acute leukaemia in childhood

Cited by 22 publications

References 25 publications

Is physical fitness decreased in survivors of childhood leukemia? A systematic review

Is physical fitness decreased in survivors of childhood leukemia? A systematic review

Physical Inactivity in Adult Survivors of Childhood Acute Lymphoblastic Leukemia: A Report from the Childhood Cancer Survivor Study

Recovery kinetics of heart rate and oxygen uptake in long-term survivors of acute leukemia in childhood

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