Physical Performance During the Menopausal Transition and the Role of Physical Activity

Bondarev, Dmitriy; Finni, Taija; Kokko, Katja; Kovanen, Vuokko; Laakkonen, Eija K.; Sipilä, Sarianna

doi:10.1093/gerona/glaa292

Cited by 23 publications

(25 citation statements)

References 38 publications

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“…Handgrip strength measurement can be used as an indicator of general muscle strength among older people [ 54 ]. Maximal Nm was calculated from the best attempt measured in Newtons (N) multiplied by lower leg length (the distance between the lateral joint line of the knee and the midline of a cuff around the ankle) [ 55 ].…”

Section: Methodsmentioning

confidence: 99%

Blood and skeletal muscle ageing determined by epigenetic clocks and their associations with physical activity and functioning

et al. 2021

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The aim of this study was to investigate the correspondence of different biological ageing estimates (i.e. epigenetic age) in blood and muscle tissue and their associations with physical activity (PA), physical function and body composition. Two independent cohorts (N = 139 and N = 47) were included, whose age span covered adulthood (23–69 years). Whole blood and m. vastus lateralis samples were collected, and DNA methylation was analysed. Four different DNA methylation age (DNAmAge) estimates were calculated using genome-wide methylation data and publicly available online tools. A novel muscle-specific methylation age was estimated using the R-package ‘MEAT’. PA was measured with questionnaires and accelerometers. Several tests were conducted to estimate cardiorespiratory fitness and muscle strength. Body composition was estimated by dual-energy X-ray absorptiometry. DNAmAge estimates from blood and muscle were highly correlated with chronological age, but different age acceleration estimates were weakly associated with each other. The monozygotic twin within-pair similarity of ageing pace was higher in blood (r = 0.617–0.824) than in muscle (r = 0.523–0.585). Associations of age acceleration estimates with PA, physical function and body composition were weak in both tissues and mostly explained by smoking and sex. The muscle-specific epigenetic clock MEAT was developed to predict chronological age, which may explain why it did not associate with functional phenotypes. The Horvath’s clock and GrimAge were weakly associated with PA and related phenotypes, suggesting that higher PA would be linked to accelerated biological ageing in muscle. This may, however, be more reflective of the low capacity of epigenetic clock algorithms to measure functional muscle ageing than of actual age acceleration. Based on our results, the investigated epigenetic clocks have rather low value in estimating muscle ageing with respect to the physiological adaptations that typically occur due to ageing or PA. Thus, further development of methods is needed to gain insight into muscle tissue-specific ageing and the underlying biological pathways.

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Section: Methodsmentioning

confidence: 99%

Blood and skeletal muscle ageing determined by epigenetic clocks and their associations with physical activity and functioning

et al. 2021

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“…Age-associated decline in physical functioning that results in mobility limitations or disabilities among older people [7] may also be related to low mental well-being [8]. It has been shown that women who transitioned through perimenopause to postmenopause had a decline in muscle strength and muscle power on average by 2-3%, which may suggest that the decline in physical functioning accelerates already during midlife [9,10]. However, the physical performance of more physically active middle-aged women is greater than that of less physically active peers [11].…”

Section: Introductionmentioning

confidence: 99%

Associations of physical performance and physical activity with mental well-being in middle-aged women

et al. 2021

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Background To investigate whether physical performance is independently of physical activity (PA) associated with positive and negative dimensions of mental well-being in middle-aged women. Methods Data were drawn from the Estrogenic Regulation of Muscle Apoptosis (ERMA) study in which women 47 to 55 years were randomly selected from the Finnish National Registry. They (n = 909) participated in measurements of physical performance (handgrip force, knee extension force, vertical jumping height, maximal walking speed, and six-minute walking distance). Both mental well-being (the Centre for Epidemiologic Studies Depression Scale, the International Positive and Negative Affect Schedule Short Form and the Satisfaction with Life Scale) and PA were self-reported. Associations between variables were analysed using multivariate linear regression modelling adjusted for body height, fat mass %, menopausal status and symptoms, marital status, parity, employment status, self-reported mental disorders, and use of psycholeptics and psychoanaleptics. PA was then entered into a separate model to explore its role in the associations. Results In the adjusted models, significant positive associations of six-minute walking distance with positive affectivity (B = 0.12, p = 0.002) and life satisfaction (B = 0.15, p = 0.033) were observed. No significant associations were observed between physical performance and depressive symptoms or negative affectivity. PA was positively associated with positive affectivity and life satisfaction and negatively with depressive symptoms across all the physical performance variables. Conclusions Of the physical performance dimensions, aerobic component was associated with positive mental well-being independently of PA level. In relation to other physical performance components, the results point to the benefits of physical activity for mental well-being.

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“…Handgrip strength measurement can be used as an indicator of general muscle strength among older people [52]. Maximal Nm was calculated from the best attempt measured in Newtons (N) multiplied by lower leg length (the distance between the lateral joint line of the knee and the midline of a cuff around the ankle) [53].…”

Section: Methodsmentioning

confidence: 99%

Blood and skeletal muscle ageing determined by epigenetic clocks and their associations with physical activity and functioning

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Heikkinen

Kankaanpää

et al. 2021

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The aim of this study was to investigate the correspondence of different biological ageing estimates (i.e. epigenetic age) in blood and muscle tissue and their associations with physical activity (PA), physical function and body composition. Two independent cohorts were included, whose age span covered adulthood (23-69 years). Whole blood and m. vastus lateralis samples were collected, and DNA methylation analysed. Four different DNA methylation age (DNAmAge) estimates were calculated using genome-wide methylation data and publicly available online tools. A novel muscle-specific methylation age was estimated using the R-package MEAT. PA was measured with questionnaires and accelerometers. Several tests were conducted to estimate cardiorespiratory fitness and muscle strength. Body composition was estimated by dual-energy X-ray absorptiometry. DNAmAge estimates from blood and muscle were highly correlated with chronological age, but different age acceleration estimates were weakly associated with each other. The monozygotic twin within-pair similarity of ageing pace was higher in blood (r=0.617-0.824) than in muscle (r=0.523-0.585). Associations of age acceleration estimates with PA, physical function and body composition were weak in both tissues and mostly explained by smoking and sex. The muscle-specific epigenetic clock MEAT was developed to predict chronological age, which may explain why it did not associate with functional phenotypes. The Horvath's clock and GrimAge were weakly associated with PA and related phenotypes, suggesting that higher PA would be linked to accelerated biological ageing in muscle. This may, however, be more reflective of the low capacity of epigenetic clock algorithms to measure functional muscle ageing than of actual age acceleration. Based our results, the investigated epigenetic clocks have rather low value in estimating muscle ageing with respect to the physiological adaptations that typically occur due to ageing or PA. Thus, further development of methods is needed to gain further insight into muscle tissue-specific ageing and the underlying biological pathways.

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Physical Performance During the Menopausal Transition and the Role of Physical Activity

Cited by 23 publications

References 38 publications

Blood and skeletal muscle ageing determined by epigenetic clocks and their associations with physical activity and functioning

Blood and skeletal muscle ageing determined by epigenetic clocks and their associations with physical activity and functioning

Associations of physical performance and physical activity with mental well-being in middle-aged women

Blood and skeletal muscle ageing determined by epigenetic clocks and their associations with physical activity and functioning

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