Physical performance across the thyroid function values within the normal range in adult and older persons

Ceresini, Graziano; Marina, Michela; Lauretani, Fulvio; Maggio, Marcello; Serra, Maria Francesca; Meschi, Tiziana; Bandinelli, Stefania; Ceda, Gian Paolo; Ferrucci, Luigi

doi:10.1007/s40520-018-0975-0

Cited by 8 publications

(10 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, they used a validated questionnaire to estimate PA, which is well-known to be less sensitive than accelerometers [ 45 ], in participants younger than those used in its validation study. Conflicting data have been presented by Ravaglia et al [ 46 ] and by Ceresini et al [ 31 ], who showed opposite correlations of thyroid hormones and TSH with PA. However, these studies included a small number of participants [ 46 ], much younger than those included in the present study [ 31 , 46 ], and were mainly based on validated questionnaires [ 31 , 46 ].…”

Section: Discussionmentioning

confidence: 96%

“…In the search of parameters of thyroid function correlated with healthy aging, of particular interest, in our opinion, is the observation that low-normal TSH levels have been associated with an increased risk of frailty [ 26 ] and hip-fracture in euthyroid women, but not in men, aged 65 years and more [ 27 ]. Contrarily, low-normal fT4 has been associated with better mobility, physical function and higher handgrip strength [ 28 , 29 , 30 ], while fT3 levels have been reported to correlate positively with physical performance scores in older euthyroid individuals [ 31 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Serum TSH and Daily Physical Activity in a Cohort of Nonagenarians: Results from the Mugello Study

Blasio

Dalmazi

Izzicupo

et al. 2022

JFMK

View full text Add to dashboard Cite

Background. The current literature does not furnish clear data concerning the relationship between thyroid function, sedentary time and daily physical activity (PA) in older adults with euthyroid condition. The aim of this study was to investigate the association of serum Thyrotropin-Stimulating Hormone (TSH), free Triiodothyronine (fT3) and free Thyroxine (fT4) with sedentary time and PA in a cohort of nonagenarians. Methods. A total of 108 nonagenarians (92.8 ± 3.2 years), participating in the Mugello Study, and with complete data on thyroid function, sedentary time, PA and sleeping (objectively collected through a multisensory device), were considered for the analysis. Results. Mainly, TSH negatively correlated with time spent lying down, and positively correlated with METs. fT4 levels were negatively associated with mean daily metabolic equivalents (METs) and with low-intensity PA practice (LIPAT), and positively associated with lying down and sleeping time. Similar results have been shown in the female sample. Mainly, participants with high-normal (third tertile) versus low-normal TSH (first tertile) had higher moderate-intensity PA (MIPAT) (p = 0.03). In the female sample, first TSH tertile had higher METs (p = 0.010), LIPAT (p = 0.02), MIPAT (p = 0.01) and lower time lying down (p = 0.04) than third TSH tertile. Conclusion. High-normal serum TSH and low-normal fT4 are associated with higher levels and intensity of daily PA, together with higher MIPAT continuity, in the oldest-old.

show abstract

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Serum TSH and Daily Physical Activity in a Cohort of Nonagenarians: Results from the Mugello Study

Blasio

Dalmazi

Izzicupo

et al. 2022

JFMK

View full text Add to dashboard Cite

show abstract

“…In the InCHIANTI study, after adjusting for multiple confounders, an association between physical performance and FT3, but not FT4 or TSH, was found [ 24 ]. The populations of the InCHIANTI and the Mugello studies were selected in the same region (Tuscany), but in the latter, it is represented only by nonagenarians; the two studies differed also in design, i.e., a cross-sectional design for the Mugello study and a longitudinal one for the InCHIANTI.…”

Section: Discussionmentioning

confidence: 99%

Thyroid hormone signaling is associated with physical performance, muscle mass, and strength in a cohort of oldest-old: results from the Mugello study

et al. 2020

View full text Add to dashboard Cite

Thyroid hormones (THs) play a crucial role in the homeostasis of muscle function, such as myogenesis and energy metabolism, suggesting that the thyroid may be also involved in the entropic processes of muscle aging. The aim of the present study is to evaluate the effect of TH signaling on physical performance, muscle mass, and strength in a cohort of community-dwelling oldest-old subjects (> 90 years). The study population was selected in a rural area of central Italy (Mugello, Tuscany), and the design was cross-sectional. Four hundred seventy-five subjects (130 males and 345 females) were enrolled, representing about 65% of all the nonagenarians living in the Mugello area. After adjusting for multiple confounding factors (sex, age, diabetes, and levothyroxine administration), the lowest quartile of FT3/FT4 ratio distribution showed lower physical performance compared to the other quartiles (β ± SE: − 0.49 ± 0.12; p < 0.001), whereas the highest quartile of FT3/FT4 ratio was associated with higher skeletal muscle index (β ± SE: 1.11 ± 0.42; p = 0.009). In addition, the lowest quartile of FT4 showed a statistically significant higher handgrip strength (β ± SE: 1.78 ± 0.68; p = 0.009) compared to all other quartiles. This study demonstrates that nonagenarians with higher FT3/FT4 ratios had better preserved muscle function, therefore successfully overcoming the imbalance of homeostatic and entropic processes involved in muscle aging. However, we could not establish a cause-effect relationship due to the cross-sectional design of the study.

show abstract

“…In addition it was shown that long term exercise may have different impacts on TSH levels than an acute exercise program (Hawamdeh, Baniata, Mansi, Nasr, Aburjai, 2012). However, no changes in circulating TSH were observed in elite athletes who underwent regular training (Healy, Gibney, Pentecost, Wheeler, Sonksen, 2014;de Souza et al, 2019;Ceresini et al, 2019). With this background in mind our study was undertaken and was aimed at evaluation of relationships between circulating TSH within the normal range with metabolic risk factors (glucose, insulin, lipoproteins) separately in male and female physical education students engaged in regular physical activity due to their studies.…”

Section: Introductionmentioning

confidence: 99%

Normal Levels of TSH Affect the Metabolic Profile Differently in Physically Active Males and Females

Malara

Kęska

Tkaczyk

et al. 2021

Central European Journal of Sport Sciences and Medicine

View full text Add to dashboard Cite

Our study was aimed at the evaluation of relationships between thyroid stimulating hormone (TSH) within the normal range and metabolic risk factors (glucose, insulin, HOMA-IR and lipoprotein profile) in physically active male and female students. In 219 students circulating TSH, glucose, insulin and lipoproteins were measured in blood under fasting conditions. Insulin resistance was expressed as HOMA-IR (homeostasis model assessment for insulin resistance). For further procedures 99 males and 97 regularly menstruating females with TSH 0.4-4.0 µIU/ml were accepted. In male students no correlations between circulating TSH, anthropometric and biochemical variables were noted. In females TSH within the normal range was slightly but significantly correlated with the triglyceride (TG) level (p < 0.03). However, step-wise multiple regression analysis revealed that the effect of TSH was small (p < 0.046) in relation to that found for HOMA-IR (p < 0.0009). No relationships between biochemical variables and normal levels of TSH were noted in male students. However, surprisingly normal range TSH in males was slightly but significantly correlated with the percentage of body fat and this issue needs further studies concerning measurements of different fat depots. The above data suggests that in active females TG synthesis and export from the liver is more sensitive to TSH action than in active male counterparts.

show abstract

Physical performance across the thyroid function values within the normal range in adult and older persons

Abstract: In euthyroid older adults, circulating FT3 may play an important role in the thyroid effects on physical function.

Cited by 8 publications

References 34 publications

Serum TSH and Daily Physical Activity in a Cohort of Nonagenarians: Results from the Mugello Study

Serum TSH and Daily Physical Activity in a Cohort of Nonagenarians: Results from the Mugello Study

Thyroid hormone signaling is associated with physical performance, muscle mass, and strength in a cohort of oldest-old: results from the Mugello study

Normal Levels of TSH Affect the Metabolic Profile Differently in Physically Active Males and Females

Contact Info

Product

Resources

About