Physical origins of canonical and tautomeric mutagenesis

Abstract

The problem of the origin of canonical and aberrant DNA mutations and the contribution of protons encoding DNA to genetic stability is an essential topic in molecular biology. Based on the empirical results, we reconsidered canonical and tautomeric mutations under the two-fluid model of quantum physics. We assumed that the proton-induced pressure of the DNA environment could change the concentration ratio between canonical and tautomeric base pairs, which were found to be different at and beyond the criticality level, respectively. We anticipate that the deviation of the cellular system from a specific (critical) temperature at which dynamic entropy reaches a minimum and a critical pH occurs may be the source of point mutations leading to tautomerization.