Physical Models from Physical Templates Using Biocompatible Liquid Crystal Elastomers as Morphologically Programmable Inks For 3D Printing

Baka, Zakaria A. M.; Godier, Claire; Lamy, Laureline; Mallick, Abhik; Gribova, Varvara; Figarol, Agathe; Bezdetnaya, Lina; Chateau, Alicia; Magne, Zoé; Stiefel, Marie; Louaguef, Dounia; Lavalle, Philippe; Gaffet, Éric; Joubert, O.; Alem, Halima

doi:10.1002/mabi.202370010

Cited by 2 publications

(1 citation statement)

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“…Thus, it is possible to manipulate liquid crystal elastomers (LCEs) in order to mitigate the adverse effects of toxicity and inflammation, both of which are frequently encountered when incorporating foreign substances into the human body. LCE-based structures are intentionally engineered to possess inherent biocompatibility, hence mitigating the potential for unfavorable responses and assuring their favorable acceptance by the host tissue [82].…”

Section: Lces Applicationsmentioning

confidence: 99%

From Static to Dynamic: Smart Materials Pioneering Additive Manufacturing in Regenerative Medicine

Kantaros,

Ganetsos

2023

IJMS

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The emerging field of regenerative medicine holds immense promise for addressing complex tissue and organ regeneration challenges. Central to its advancement is the evolution of additive manufacturing techniques, which have transcended static constructs to embrace dynamic, biomimetic solutions. This manuscript explores the pivotal role of smart materials in this transformative journey, where materials are endowed with dynamic responsiveness to biological cues and environmental changes. By delving into the innovative integration of smart materials, such as shape memory polymers and stimulus-responsive hydrogels, into additive manufacturing processes, this research illuminates the potential to engineer tissue constructs with unparalleled biomimicry. From dynamically adapting scaffolds that mimic the mechanical behavior of native tissues to drug delivery systems that respond to physiological cues, the convergence of smart materials and additive manufacturing heralds a new era in regenerative medicine. This manuscript presents an insightful overview of recent advancements, challenges, and future prospects, underscoring the pivotal role of smart materials as pioneers in shaping the dynamic landscape of regenerative medicine and heralding a future where tissue engineering is propelled beyond static constructs towards biomimetic, responsive, and regenerative solutions.

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Section: Lces Applicationsmentioning

confidence: 99%

From Static to Dynamic: Smart Materials Pioneering Additive Manufacturing in Regenerative Medicine

Kantaros,

Ganetsos

2023

IJMS

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The Role of Liquid Crystal Elastomers in Pioneering Biological Applications

Shiralipour,

Nik Akhtar,

Gilmor

et al. 2024

Crystals

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Liquid crystal elastomers have shown an attractive potential for various biological applications due to their unique combination of mechanical flexibility and responsiveness to external stimuli. In this review, we will focus on a few examples of LCEs used with specific applications for biological/biomedical/environmental systems. So far, areas of innovation have been concentrating on the integration of LCEs to enhance stability under physiological conditions, ensure precise integration with biological systems, and address challenges related to optical properties and spatial control of deformation. However, several challenges and limitations must still be addressed to fully realize their potential in biomedical and environmental fields, and future research should focus on continuing to improve biocompatibility, response to the environment and chemical cues, mechanical properties, ensuring long-term stability, and establishing cost-effective production processes. So far, 3D/4D printing appears as a great promise to develop materials of high complexity, almost any shape, and high production output. However, researchers need to find ways to reduce synthesis costs to ensure that LCEs are developed using cost-effective production methods at a scale necessary for their specific applications’ needs.

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Physical Models from Physical Templates Using Biocompatible Liquid Crystal Elastomers as Morphologically Programmable Inks For 3D Printing

Cited by 2 publications

References 0 publications

From Static to Dynamic: Smart Materials Pioneering Additive Manufacturing in Regenerative Medicine

From Static to Dynamic: Smart Materials Pioneering Additive Manufacturing in Regenerative Medicine

The Role of Liquid Crystal Elastomers in Pioneering Biological Applications

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