Physical, mechanical and wound healing properties of chitosan/gelatin blend films containing tannic acid and/or bacterial nanocellulose

Taheri, Parisa; Jahanmardi, Reza; Koosha, Mojtaba; Abdi, Shabnam

doi:10.1016/j.ijbiomac.2020.03.114

Cited by 126 publications

(74 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results of the mechanical analyses indicate that the TS of AX-GL increased when the AX contents in films were increased from 2% to 2.5%. This tensile behavior can be explained as an increase in AX contents that results in increased interaction between components of the films and consequently produces more rigid films [31]. On the other hand, it was observed that the EAB (%) of AXGL4 was greater than that of AXGL3 and AXGL5.…”

Section: Mechanical Analyses Of Ax-gl Filmsmentioning

confidence: 99%

“…The WVTR is considered an important character for wound dressing materials as it aids in the absorption of wound exudate, maintenance of a moist environment, and exchange of gases, which are essential for ideal wound healing [9,34]. The WVTR of polymeric films is mainly governed by the hydrophilicity, thickness, amount of solids, porosity, and crystallinity of the films [31]. Therefore, the high WVTR of AX-GL films can be attributed to the presence of hydrophilic polymers in the film formulation.…”

Section: Water Vapor Transmission Ratementioning

confidence: 99%

See 1 more Smart Citation

Antibiotic-Loaded Psyllium Husk Hemicellulose and Gelatin-Based Polymeric Films for Wound Dressing Application

Ahmad

Alruwaili

et al. 2021

Pharmaceutics

View full text Add to dashboard Cite

Wound infections are one of the major reasons for the delay in the healing of chronic wounds and can be overcome by developing effective wound dressings capable of absorbing exudate, providing local antibiotic release, and improving patient comfort. Arabinoxylan (AX) is a major hemicellulose present in psyllium seed husk (PSH) and exhibits promising characteristics for developing film dressings. Herein, AX-gelatin (GL) films were prepared by blending AX, gelatin (GL), glycerol, and gentamicin (antibiotic). Initially, the optimal quantities of AX, GL, and glycerol for preparing transparent, bubble-free, smooth, and foldable AX-GL films were found. Physiochemical, thermal, morphological, drug release, and antibacterial characteristics of the AX-GL films were evaluated to investigate their suitability as wound dressings. The findings suggested that the mechanical, water vapor transmission, morphological, and expansion characteristics of the optimized AX-GL films were within the required range for wound dressing. The results of Fourier-transform infrared (FTIR) analyses suggested chemical compatibility among the ingredients of the films. In in vitro drug release and antibacterial activity experiments, gentamicin (GM)-loaded AX-GL films released approximately 89% of the GM in 24 h and exhibited better antibacterial activity than standard GM solution. These results suggest that AX-GL films could serve as a promising dressing to protect against wound infections.

show abstract

Section: Mechanical Analyses Of Ax-gl Filmsmentioning

confidence: 99%

Section: Water Vapor Transmission Ratementioning

confidence: 99%

Antibiotic-Loaded Psyllium Husk Hemicellulose and Gelatin-Based Polymeric Films for Wound Dressing Application

Ahmad

Alruwaili

et al. 2021

Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…After 14 days of wound treatment, the newly established extracellular matrix over scar tissue reported at a greater rate the aggregation of in ammatory cells, broblasts, and collagen bundles [41]. The in ammatory response was observed on day 7 to varying degrees in all groups; the development of granulation materials, with all the creation of new small blood vessels and hair follicles, in the wound treated with PSA-Gel-TA hydrogels [38,42].…”

Section: In Vivo Wound Healing Studymentioning

confidence: 99%

Preparation and characterization of a novel polysialic acid/gelatin composite hydrogels cross-linked by Tannic acid to improve healing and nursing care of cesarean section dressing

Zhang¹,

Chunjie²,

Wang³

et al. 2021

Preprint

View full text Add to dashboard Cite

The infections and delayed wound healing after cesarean delivery is one of the most complicated issues in surgical medicinal field. In the present investigation, designed novel polysialic acid loaded gelatin (PSA-Gel) composite hydrogels cross-linked by tannic acid (TA) has been developed and used as a facile wound dressing to improve cesarean wound healing ability with prevent bactericidal infections. The cross-linking effect was predominant when the TA content was lower, resulting in the formation of a cross-linked network. An effective TA cross-linking effect on the PSA-Gel hydrogel matrix was achieved when the amount of TA was around 15 wt %. The morphology of as-fabricated hydrogels was characterized using scanning electron microscopy (SEM) with an average pore sizes of PSA-Gel, PSA-Gel-TA-5%, PSA-Gel-TA-10%, and PSA-Gel-TA-15% hydrogels were 95.4 ± 12.6 µm, 120.4 ± 8.2 µm, 165.3 ± 21.6 µm, and 270.2 ± 32.5 µm, respectively. The effects of hydrogels on the swelling ratio, in vitro degradation, and mechanical properties were systemically evaluated. The TA cross-linked PSA-Gel hydrogels display strong antimicrobial behavior against gram-positive (Staphylococcus aureus) gram-negative (Escherichia coli) bacteria strains. Moreover, PSA-Gel-TA hydrogels also displayed favorable cytotoxicity toward L929 fibroblast cell lines. Finally, the therapeutic and wound healing potential of the PSA-Gel-TA hydrogels has been studied in vivo using the excision wound model in rats. The results indicate that the PSA-Gel-TA hydrogels have a greater and significant effect on wound closure and increased the wound healing rate compared with native PSA-Gel hydrogels and untreated control group. The findings suggest that PSA-Gel-TA hydrogels are promising dressing materials for the treatment of wound healing.

show abstract

“…Chitosan is a natural polymer with both biocompatibility and antibacterial property, which inhibits the synthesis of mRNA and protein via penetration into the nuclei of bacteria and binding with DNA 7,8 . Although chitosan‐based films exhibit good bactericidal activity, their poor mechanical properties, such as, tensile strength and flexibility, restrict their biomedical applications, especially as wound dressings 9 . To improve the flexibility and tensile strength, some researchers have employed the incorporation of chitosan and liquid silicone rubber (SR) as an alternative.…”

Section: Introductionmentioning

confidence: 99%

“…7,8 Although chitosan-based films exhibit good bactericidal activity, their poor mechanical properties, such as, tensile strength and flexibility, restrict their biomedical applications, especially as wound dressings. 9 To improve the flexibility and tensile strength, some researchers have employed the incorporation of chitosan and liquid silicone rubber (SR) as an alternative. In this case, the chitosan/SR blend not only shows good antibacterial activity but it also represents improved mechanical properties.…”

Section: Introductionmentioning

confidence: 99%

Preparation, characterization, and antibacterial activity of chitosan/silicone rubber filled zeolite, silver, and copper nanocomposites againstPseudomonas aeruginosaand methicillin‐resistantStaphylococcus aureus

Rezazadeh

Kianvash

2021

J of Applied Polymer Sci

View full text Add to dashboard Cite

The ongoing emergence of antibiotic‐resistant bacteria has become one of the biggest threats to global health and development today. Pseudomonas aeruginosa and methicillin‐resistant Staphylococcus aureus (MRSA) are important antibiotic‐resistant bacteria due to their increasing resistance to a broad array of antimicrobial agents. Herein, we developed a novel antibacterial nanocomposite based on chitosan and liquid silicone rubber filled zeolite‐A, Ag, and Cu nanoparticles with remarkable antibacterial activity against P. aeruginosa and MRSA. The antibacterial activity of the nanocomposite was studied by disc diffusion and broth culture methods. Besides, the mechanical properties, wetting behavior, and chemical structure of the present nanocomposite were also investigated. The results exhibited that the inhibition zone diameter of the nanocomposite for P. aeruginosa and MRSA were 40 and 27 mm, respectively. It also took approximately 1 h to inhibit the growth of the tested bacteria. The nanocomposite sample with a thickness of around 1 mm showed an elastic elongation of nearly 49% and a contact angle of roughly 120°. Thus, the present nanocomposite was found to be useful in killing and inhibiting the growth of P. aeruginosa and MRSA, and it could also be qualified as a superior elastic and hydrophobic material.

show abstract

Physical, mechanical and wound healing properties of chitosan/gelatin blend films containing tannic acid and/or bacterial nanocellulose

Cited by 126 publications

References 36 publications

Antibiotic-Loaded Psyllium Husk Hemicellulose and Gelatin-Based Polymeric Films for Wound Dressing Application

Antibiotic-Loaded Psyllium Husk Hemicellulose and Gelatin-Based Polymeric Films for Wound Dressing Application

Preparation and characterization of a novel polysialic acid/gelatin composite hydrogels cross-linked by Tannic acid to improve healing and nursing care of cesarean section dressing

Preparation, characterization, and antibacterial activity of chitosan/silicone rubber filled zeolite, silver, and copper nanocomposites againstPseudomonas aeruginosaand methicillin‐resistantStaphylococcus aureus

Contact Info

Product

Resources

About