Physical Mapping of the Mouse Genome

Herman, Gail E.

doi:10.1006/meth.1997.0573

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Positional Cloning Strategy1

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1998

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Cited by 8 publications

(1 citation statement)

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“…3). As recently as a few years ago, once a candidate region was delimited by genetic markers, it was necessary to define the physical map region and genes contained therein experimentally by isolating large insert DNA clones followed by exon trapping or cDNA selection (25,26). This tedious process has largely been replaced by simple database queries.…”

Section: Positional Cloning Strategymentioning

confidence: 99%

Thematic review series: Systems Biology Approaches to Metabolic and Cardiovascular Disorders Approaches to lipid metabolism gene identification and characterization in the postgenomic era

Reue¹,

Vergnes²

2006

Journal of Lipid Research

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The availability of genomic resources has already had a tremendous impact on biomedical research. In this review, we describe how whole genome sequence and highthroughput functional genomics projects have facilitated the identification and characterization of important genes in lipid metabolism and disease. We review key approaches and lipid genes identified in the first years of this century and discuss how genomic resources are likely to streamline gene identification and functional characterization in the future.-Reue, K., and L. Vergnes. Approaches to lipid metabolism gene identification and characterization in the postgenomic era.

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Section: Positional Cloning Strategymentioning

confidence: 99%