Physical mapping of the herpes simplex virus type 2 nuc- lesion affecting alkaline exonuclease activity by using herpes simplex virus type 1 deletion clones

Wathen, Michael W.; Hay, John

doi:10.1128/jvi.51.1.237-241.1984

Cited by 2 publications

(1 citation statement)

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“…HSV-1 also encodes an alkaline nuclease or deoxyribonuclease, which is a phosphoprotein with endo-and exonuclease activity, which localizes to the nucleus of infected cells [372][373][374][375]. The alkaline nuclease is encoded by the U L 12 gene of HSV-1 [22,374,[376][377][378][379]. The U L 12 gene of HSV-1 is highly related in sequence to proteins from other herpes viruses [380][381][382][383].…”

Section: Nucleic Acid Metabolism and Endonucleasesmentioning

confidence: 99%

“Non-Essential” Proteins of HSV-1 with Essential Roles In Vivo: A Comprehensive Review

Dogrammatzis

Waisner

Kalamvoki

2020

Viruses

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Viruses encode for structural proteins that participate in virion formation and include capsid and envelope proteins. In addition, viruses encode for an array of non-structural accessory proteins important for replication, spread, and immune evasion in the host and are often linked to virus pathogenesis. Most virus accessory proteins are non-essential for growth in cell culture because of the simplicity of the infection barriers or because they have roles only during a state of the infection that does not exist in cell cultures (i.e., tissue-specific functions), or finally because host factors in cell culture can complement their absence. For these reasons, the study of most nonessential viral factors is more complex and requires development of suitable cell culture systems and in vivo models. Approximately half of the proteins encoded by the herpes simplex virus 1 (HSV-1) genome have been classified as non-essential. These proteins have essential roles in vivo in counteracting antiviral responses, facilitating the spread of the virus from the sites of initial infection to the peripheral nervous system, where it establishes lifelong reservoirs, virus pathogenesis, and other regulatory roles during infection. Understanding the functions of the non-essential proteins of herpesviruses is important to understand mechanisms of viral pathogenesis but also to harness properties of these viruses for therapeutic purposes. Here, we have provided a comprehensive summary of the functions of HSV-1 non-essential proteins.

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