Physical mapping of the class I regions of the rat major histocompatibility complex

Günther, Eberhard; Ioannidu, Sofia; Walter, Lutz

doi:10.1007/978-4-431-65868-9_6

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Mhc Class I Regions Of Rat Human and Mouse1

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2000

2001

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Cited by 2 publications

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“…Whereas the scheme is roughly to scale for the HLA complex, it is not for RT1 and H2 because of lack of precise information. The HLA data are from The MHC sequencing consortium (1999), mouse data from Amadou et al (1999) and rat data from Günther et al (2000) and our own unpublished experiments. It should be noted that different designations, not always following standardized nomenclature, are in use for several framework genes.…”

Section: Mhc Class I Regions Of Rat Human and Mousementioning

confidence: 99%

Comparative genomic aspects of rat, mouse and human MHC class I gene regions

Günther¹,

Walter²

2000

Cytogenet Genome Res

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Section: Mhc Class I Regions Of Rat Human and Mousementioning

confidence: 99%

Comparative genomic aspects of rat, mouse and human MHC class I gene regions

Günther¹,

Walter²

2000

Cytogenet Genome Res

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Physical Map and Expression Profile of Genes of the Telomeric Class I Gene Region of the Rat MHC

Ioannidu

Walter

Dressel

et al. 2001

The Journal of Immunology

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The rat is an important model for studying organ graft rejection and susceptibility to certain complex diseases. The MHC, the RT1 complex, plays a decisive role in controlling these traits. We have cloned the telomeric class I region of the RT1 complex, RT1-C/E/M, of the BN inbred rat strain in a contig of overlapping P1-derived artificial chromosome clones encompassing ∼2 Mb, and present a physical map of this MHC region. Forty-five class I exon 4-hybridizing BamHI fragments were detected, including the previously known rat class I genes RT1-E, RT-BM1, RT1-N, RT1-M2, RT1-M3, and RT1-M4. Twenty-six non-class I genes known to map to the corresponding part of the human and mouse MHC were tested and could be fine mapped in the RT1-C/E/M region at orthologous position. Four previously known microsatellite markers were fine mapped in the RT1-C/E/M region and found to occur in multiple copies. In addition, a new, single-copy polymorphic microsatellite has been defined. The expression profiles of several class I genes and the 26 non-class I genes were determined in 13 different tissues and exhibited restricted patterns in most cases. The data provide further molecular information on the MHC for analyzing disease susceptibility and underline the usefulness of the rat model.

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Physical mapping of the class I regions of the rat major histocompatibility complex

Cited by 2 publications

References 45 publications

Comparative genomic aspects of rat, mouse and human MHC class I gene regions

Comparative genomic aspects of rat, mouse and human MHC class I gene regions

Physical Map and Expression Profile of Genes of the Telomeric Class I Gene Region of the Rat MHC

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