Physical interactions in macroporous scaffolds based on poly(ɛ-caprolactone)/chitosan semi-interpenetrating polymer networks

Cruz, Dunia M. García; Coutinho, Daniela F.; Mano, João F.; Ribelles, J.L. Gómez; Salmerón-Sánchez, Manuel

doi:10.1016/j.polymer.2009.02.046

Cited by 37 publications

(12 citation statements)

References 21 publications

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“…The lower stiffness for the CS- g -PCL sample is attributed to the lower degree of crystallinity of CS chains in the graft copolymer. A similar effect has been reported earlier by [10], which claimed that blending of CS and PCL occurs via hydrogen bond formation between the functional groups present in the CS molecule (–NH 2 and –OH) and the carbonyl groups of PCL, which also resulted in the suppression of the PCL crystallization [10,24,30,33,52].…”

Section: Resultssupporting

confidence: 80%

“…The last several years there has been a tremendous attempt to blend CS and PCL, although these materials are considered immiscible [24,25,26,27,28]. It is believed that mixing hydrophilic CS with the hydrophobic PCL will allow for the improvement of water diffusion to the proximity of the hydrophobic chains and, thus, accelerate the hydrolytic degradation of the latter [29].…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, Nanomechanical Characterization and Biocompatibility of a Chitosan-Graft-Poly(ε-caprolactone) Copolymer for Soft Tissue Regeneration

et al. 2019

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Tissue regeneration necessitates the development of appropriate scaffolds that facilitate cell growth and tissue development by providing a suitable substrate for cell attachment, proliferation, and differentiation. The optimized scaffolds should be biocompatible, biodegradable, and exhibit proper mechanical behavior. In the present study, the nanomechanical behavior of a chitosan-graft-poly(ε-caprolactone) copolymer, in hydrated and dry state, was investigated and compared to those of the individual homopolymers, chitosan (CS) and poly(ε-caprolactone) (PCL). Hardness and elastic modulus values were calculated, and the time-dependent behavior of the samples was studied. Submersion of PCL and the graft copolymer in α-MEM suggested the deterioration of the measured mechanical properties as a result of the samples’ degradation. However, even after three days of degradation, the graft copolymer presented sufficient mechanical strength and elastic properties, which resemble those reported for soft tissues. The in vitro biological evaluation of the material clearly demonstrated that the CS-g-PCL copolymer supports the growth of Wharton’s jelly mesenchymal stem cells and tissue formation with a simultaneous material degradation. Both the mechanical and biological data render the CS-g-PCL copolymer appropriate as a scaffold in a cell-laden construct for soft tissue engineering.

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Section: Resultssupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Synthesis, Nanomechanical Characterization and Biocompatibility of a Chitosan-Graft-Poly(ε-caprolactone) Copolymer for Soft Tissue Regeneration

et al. 2019

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“…Some difficulties have frequently been encountered when blending PCL with CHT: (i) melting processing techniques may be used to blend CHT and PCL but only if the CHT content is not too high as it cannot melt; (ii) there are very few shared solvents available for CHT and PCL in order to process them using wet‐based technologies . The common solvent 1,1,1,3,3,3‐hexa‐fluoro‐2‐propanol (HFIP) has been proposed to process PCL/CHT blends .…”

Section: Introductionmentioning

confidence: 99%

Development of new poly(ϵ-caprolactone)/chitosan films

2013

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This study reports for the first time the production of poly(ε-caprolactone)/chitosan (PCL/CHT) films by solvent casting using a mixture of formic acid/acetone (70:30 vol%). Both uncrosslinked and crosslinked films with the natural crosslinker genipin were developed. The mechanical properties of the samples were analyzed by dynamical mechanical analysis (DMA) in the hydrated state. DMA was also successfully used for the first time to monitor in situ the crosslinking process as a function of time and crosslinker concentration. The compatibility between the polymers in the blended films was analyzed by Fourier transform infrared (FTIR) spectroscopy and differential scanning calorimetry (DSC). It was found that phase distribution is highly dependent on the blend composition. The developed films could potentially be used in different applications, such as tissue engineering scaffolds.

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“…Different polymeric membranes have been produced for the recovery of skin lesions such as burns and wounds caused by chronic illnesses or resulting from accidents. In particular, skin dressings based on polysaccharides such as chitosan (Ch) have frequently been studied for this purpose [2][3][4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

“…Previous work [7,8,20] focusing on the use of Ch mixed with PCL showed very promising results regarding the development of new polymer hybrids. Sarasam and Madihally [21] report good results with regard to biomechanical aspects of the blend.…”

Section: Introductionmentioning

confidence: 99%

Characterization of chitosan and polycaprolactone membranes designed for wound repair application

et al. 2011

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Polycaprolactone (PCL) and chitosan (Ch) are nontoxic, biocompatible, and biodegradable polymers of vast interest for wound repair. The aim of this work was to prepare Ch/PCL membranes in different proportions (90:10 and 80:20 w/w) in the presence and absence of the surfactant Pluronic F68 (PF68). The membranes were evaluated regarding morphology, thermal behavior, and viscoelastic properties. Sample swelling and degradation in phosphate-buffered saline (PBS), simulated body fluid (SBF), and fetal bovine serum (FBS) were determined by differential scanning calorimetry (DSC) and dynamical mechanical analysis (DMA), while cell toxicity to L929 and Vero fibroblasts was evaluated using the MTT reduction assay and cell proliferation, by DNA quantification and confocal laser microscopy. After 60 days in SBF, marked Ch matrix loss and advanced degradation of PCL particles were noticed by scanning electron microscopy (SEM). No significant differences in melting temperature (T m) and enthalpy (DH m) were detected by DSC. However, the surfactant increased the DH m. After 30 days, the membranes obtained in the presence of PF68 had absorbed more blood serum and were more degraded after exposure to simulated blood fluid for 30 days. All membranes had low cytotoxicity, and higher cell proliferation was noticed for samples obtained in the presence of the surfactant. In conclusion, the Ch/PCL membranes showed satisfactory degradability and biocompatibility, which enhances their potential for application in wound repair.

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Physical interactions in macroporous scaffolds based on poly(ɛ-caprolactone)/chitosan semi-interpenetrating polymer networks

Cited by 37 publications

References 21 publications

Synthesis, Nanomechanical Characterization and Biocompatibility of a Chitosan-Graft-Poly(ε-caprolactone) Copolymer for Soft Tissue Regeneration

Synthesis, Nanomechanical Characterization and Biocompatibility of a Chitosan-Graft-Poly(ε-caprolactone) Copolymer for Soft Tissue Regeneration

Development of new poly(ϵ-caprolactone)/chitosan films

Characterization of chitosan and polycaprolactone membranes designed for wound repair application

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