Physical Inactivity and Pancreatic Cancer Mortality

Pratapwar, Megha; Stenzel, Ashley E.; Joseph, Janine M.; Fountzilas, Christos; Etter, John Lewis; Mongiovi, Jennifer; Cannioto, Rikki A.; Moysich, Kirsten B.

doi:10.1007/s12029-020-00441-9

Cited by 5 publications

(3 citation statements)

References 21 publications

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“…In the European Prospective Investigation into Cancer and Nutrition (EPIC) trial where over 1100 patients were followed for 15 years, a healthy lifestyle was also found to have a protective effect against pancreatic cancer incidence [18]. Perhaps most compelling was the finding that a history of physical inactivity prior to being diagnosed with pancreatic adenocarcinoma was associated with an increased mortality rate and that obesity seems to confer a higher rate of chemotherapy resistance [19,20]. Clinical trials and meta-analyses regarding the link between obesity and the metabolic syndrome and pancreatic cancer, but no randomized-controlled trials exist.…”

Section: Obesitymentioning

confidence: 99%

Systematic Review of the Integrative Medicine Recommendations for Patients with Pancreatic Cancer

et al. 2021

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Introduction: Integrative medicine (IM) is a relatively new field where non-traditional therapies with peer-reviewed evidence are incorporated or integrated with more traditional approaches. Methods: A systematic review of the literature from the last 10 years was done by searching clinical trials and randomized-controlled trials on Pubmed that discuss nutrition, supplementation, and lifestyle changes associated with “Pancreatic Cancer.” Results: Only 50 articles ultimately met the inclusion criteria for this review. A total of 15 articles discussed the role of obesity and 10 discussed the influence of stress in increasing the risk of pancreatic cancer. Six discussed the potential beneficial role of Vitamins, 5 of cannabinoids, 4 an anti-inflammatory diet, 3 of nut consumption, 2 of green tea consumption, 2 of curcumin supplementation, 1 role of melatonin, and 1 of probiotics. One article each was found on the theoretical benefits of adhering to either a Mediterranean or ketogenic diet. Discussion: As more surgeons become interested in IM, it is hoped that more diseases where the curative treatment is mainly surgical can benefit from the all-encompassing principles of IM in an effort to improve quality of life and survival in patients with pancreatic cancer.

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Section: Obesitymentioning

confidence: 99%

Systematic Review of the Integrative Medicine Recommendations for Patients with Pancreatic Cancer

et al. 2021

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“…4,5 Epidemiological studies have identified several modifiable risk factors associated with PDAC. These factors include overweight and obesity, 6,7 physical inactivity, 8 smoking, 9,10 alcohol consumption 11 and diabetes mellitus. 12 Additionally, there are non-modifiable risk factors such as age, 13 chronic pancreatitis, 11 and genetic factors/family history of PDAC.…”

Section: Introductionmentioning

confidence: 99%

Recent Developments in the Treatment of Pancreatic Cancer

Paulino,

Mansinho

2023

Acta Med Port

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Pancreatic duct adenocarcinoma is currently the sixth-leading cause of cancer death worldwide and the fourth in Europe, with a continuous increase in annual lethality in Portugal during the last two decades. Surgical en-bloc resection of the tumor with microscopic-negative margins and an adequate lymphadenectomy is the only possibility of long-term survival. As this type of cancer is a systemic disease, there is a high rate of recurrence even after curative resection, turning systemic therapy the core of its management, mostly based on chemotherapy. Neoadjuvant strategies for nonmetastatic disease showed significant improvement in overall survival compared with upfront surgery, namely in borderline resectable disease. Moreover, these strategies provided downstaging in several situations allowing R0 resections. Under these new oncologic strategies, several recent surgical issues were introduced, namely more aggressive vascular resections and even tumor resections in oligometastatic disease. This review revisits the state-of-the-art of surgical and oncological interventions in pancreatic duct adenocarcinoma and highlights recent advances in the field aiming to achieve higher survival rates.

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“…Epidemiological studies have suggested different modifiable risk factors for PDAC, including overweight and obesity ( 8 , 9 ), physical inactivity ( 10 ), smoking ( 11 , 12 ), alcohol consumption ( 13 , 14 ) and diabetes mellitus (DM) ( 15 ), as well as non-modifiable risk factors, such as age ( 16 ), chronic pancreatitis ( 13 , 14 ) and genetic factors/family history of PDAC ( 17 , 18 ). A previous systematic review and meta-analysis of 23 prospective studies including 9,504 patients revealed that a BMI >25 kg/m 2 and high waist circumference increase the risk of pancreatic cancer ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

Treatment optimization of locally advanced and metastatic pancreatic cancer (Review)

Barros¹,

Pulido

Machado

et al. 2021

Int J Oncol

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Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignant tumor types, being the sixth leading cause of mortality worldwide and the fourth in Europe. Globally, it has a mortality/incidence ratio of 98%, and the 5-year survival rate in Europe is only 3%. Although risk factors, such as obesity, diabetes mellitus, smoking, alcohol consumption and genetic factors, have been identified, the causes of PDAC remain elusive. Additionally, the only curative treatment for PDAC is surgery with negative margins. However, upon diagnosis, ~30% of the patients already present with locally advanced disease. In these cases, a multidisciplinary approach is required to improve disease-related symptoms and prolong patient survival. In the present article, a comprehensive review of PDAC epidemiology, physiology and treatment is provided. Moreover, guidelines on patient treatment are suggested. Among the different available therapeutic options for the treatment of advanced PDAC, results are modest, most likely due to the complexity of the disease, and so the prognostic remains poor. Molecular approaches based on multi-omics research are promising and will contribute to groundbreaking personalized medicine. Thus, economic investment that promotes research of pancreatic cancer will be critical to the development of more efficient diagnostic and treatment strategies.

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Physical Inactivity and Pancreatic Cancer Mortality

Cited by 5 publications

References 21 publications

Systematic Review of the Integrative Medicine Recommendations for Patients with Pancreatic Cancer

Systematic Review of the Integrative Medicine Recommendations for Patients with Pancreatic Cancer

Recent Developments in the Treatment of Pancreatic Cancer

Treatment optimization of locally advanced and metastatic pancreatic cancer (Review)

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