Physical (in)activity and its influence on disease-related features, physical capacity, and health-related quality of life in a cohort of chronic juvenile dermatomyositis patients
“…Our patients were less physically active than our controls and the general, Norwegian population (PAPER II and III). However, physical activity levels in our patients were comparable to a Danish JDM cohort (74) and higher than a Brazilian JDM cohort (110). Compared with the Brazilian cohort, a smaller proportion of patients had inactive disease (PRINTO) (70% vs 89%).…”
Section: Physical Activitysupporting
confidence: 46%
“…(SD3.2) years disease duration), a larger proportions of our patients still had active disease (36-51% vs 11%) despite a longer disease duration (110).…”
Section: Representativenessmentioning
confidence: 54%
“…In PAPER II, CRF was reduced in patients compared to controls similar to other JDM studies (74,99,100), although our study showed smaller differences between patients and controls. As our patients also had physical activity levels comparable to a Danish cohort, but higher than a Brazilian cohort (74,110), this may reflect that we had a more physically active patient group compared to other cohorts or might be explained by a gradual improvement in CRF with longer disease duration (PAPER II).…”
Section: Primary Outcomes In the Total Cohort Compared To Literaturementioning
Submaximal exercise capacity was reduced in patients with JDM, particularly those with active disease. This reduction was associated with muscle and lung dysfunction and poorer HRQOL.
“…Our patients were less physically active than our controls and the general, Norwegian population (PAPER II and III). However, physical activity levels in our patients were comparable to a Danish JDM cohort (74) and higher than a Brazilian JDM cohort (110). Compared with the Brazilian cohort, a smaller proportion of patients had inactive disease (PRINTO) (70% vs 89%).…”
Section: Physical Activitysupporting
confidence: 46%
“…(SD3.2) years disease duration), a larger proportions of our patients still had active disease (36-51% vs 11%) despite a longer disease duration (110).…”
Section: Representativenessmentioning
confidence: 54%
“…In PAPER II, CRF was reduced in patients compared to controls similar to other JDM studies (74,99,100), although our study showed smaller differences between patients and controls. As our patients also had physical activity levels comparable to a Danish cohort, but higher than a Brazilian cohort (74,110), this may reflect that we had a more physically active patient group compared to other cohorts or might be explained by a gradual improvement in CRF with longer disease duration (PAPER II).…”
Section: Primary Outcomes In the Total Cohort Compared To Literaturementioning
Submaximal exercise capacity was reduced in patients with JDM, particularly those with active disease. This reduction was associated with muscle and lung dysfunction and poorer HRQOL.
“…Each accelerometer-containing device collects acceleration magnitude multiple times each second and/or provides a summarized measure of physical activity. Measures of physical activity included the “Euclidean Norm Minus One” (GENEActiv device) [28], time spent in light, moderate or vigorous states (Actical, ActiGraph GT3X devices) [21, 23, 24, 26, 27], “counts” per minute (CPM, ActiGraph GT1M device) [22, 27] and number of steps recorded in 48 h (Sense Wear device) [25]. Fig.…”
BackgroundThe idiopathic inflammatory myopathies (IIMs) are a group of rare conditions characterised by muscle inflammation (myositis). Accurate disease activity assessment is vital in both clinical and research settings, however, current available methods lack ability to quantify associated variation of physical activity, an important consequence of myositis.This study aims to review studies that have collected accelerometer-derived physical activity data in IIM populations, and to investigate if these studies identified associations between physical and myositis disease activity.MethodsA narrative review was conducted to identify original articles that have collected accelerometer-derived physical activity data in IIM populations. The following databases were searched from February 2000 until February 2019: Medline via PubMed, Embase via OVID and Scopus.ResultsOf the 297 publications screened, eight studies describing accelerometer use in 181 IIM cases were identified. Seven out of the eight studies investigated juvenile dermatomyositis (JDM) populations and only one reported on an adult-onset population. Population sizes, disease duration, accelerometer devices used, body placement sites, and study duration varied between each study.Accelerometer-derived physical activity levels were reduced in IIM cohorts, compared to healthy controls, and studies reported improvement of physical activity levels following exercise programme interventions, thus demonstrating efficacy.Higher levels of accelerometer-derived physical activity measurements were associated with shorter JDM disease duration, current glucocorticoid use and lower serum creatine kinase. However, no clear association between muscle strength and accelerometer-derived physical activity measures was identified.ConclusionsThe use of accelerometer-derived physical activity in IIM research is in its infancy. Whilst knowledge is currently limited to small studies, the opportunities are promising and future research in this area has the potential to improve disease activity assessment for clinical and research applications.
“…Os pacientes com DMJ com gengivite apresentaram idade atual[12,4 (8,3-18,4) vs 9,2(5,(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)5), p=0,034] e tempo de seguimento (7,09 ± 3,07 vs presente estudo demonstrou que a inflamação gengival e perda da inserção dentária parecem estar relacionadas à dislipidemia em pacientes com DMJ, sugerindo mecanismos comuns subjacentes para ambas as comorbidades.Ainda em relação as anormalidades do perfil lipídico, a presença do anticorpo anti-LPL, um auto anticorpo já associado à hipertrigliceridemia em pacientes com LES42 , foi identificada em apenas um dos pacientes estudados, não sendo possível, portanto, atribuir sua presença às alterações lipídicas encontradas em nossa casuística.…”
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