Physical health and schizophrenia

Mitchell, Alex J.; Malone, Darren

doi:10.1097/01.yco.0000228767.71473.9e

Cited by 88 publications

(63 citation statements)

References 53 publications

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“…Finally, a number of studies have suggested that the increased medical comorbidity among persons with schizophrenia is due to inadequate medical care provision by psychiatrists or PCPs, or both (Jeste et al, 1996;Druss et al, 2001a;Meyer and Nasrallah, 2003;Schoos and Cohen, 2003;Marder et al, 2004;Goff et al, 2005;Mitchell and Malone, 2006). Vahia and coauthors (2008) found that older persons with schizophrenia were significantly less likely than their age peers to receive medications for several common medical conditions.…”

Section: Introductionmentioning

confidence: 95%

A pilot study to assess attitudes, behaviors, and inter‐office communication by psychiatrists and primary care providers in the care of older adults with schizophrenia

Jones¹,

Vahia

Cohen

et al. 2008

Int J Geriat Psychiatry

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Section: Introductionmentioning

confidence: 95%

A pilot study to assess attitudes, behaviors, and inter‐office communication by psychiatrists and primary care providers in the care of older adults with schizophrenia

Jones¹,

Vahia

Cohen

et al. 2008

Int J Geriat Psychiatry

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“…2 Younger adults with schizophrenia are prone to diseases associated with aging such as diabetes and cardiovascular disorders. [3][4][5][6][7] The average life span of a person with schizophrenia is 15-20 years shorter than that of an unaffected person, 2,8 and patients with schizophrenia have 2-12 times higher mortality rate than age-comparable general population. [9][10][11] Given that lifespans are generally increasing for the population as a whole, 12 understanding alterations in the aging process within schizophrenia is clearly imperative.…”

Section: "Besides the Psychic Disorders There Are Also In The Physicmentioning

confidence: 99%

Systemic Biomarkers of Accelerated Aging in Schizophrenia: A Critical Review and Future Directions

Nguyen

Eyler

Jeste

2017

Schizophrenia Bulletin

103

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Background: Schizophrenia is associated with increased physical morbidity and early mortality, suggesting that the aging process may be accelerated in schizophrenia. However, the biological underpinnings of these alterations in aging in schizophrenia are unclear. Method: We conducted a detailed search of peer-reviewed empirical studies to evaluate evidence for accelerated biological aging in schizophrenia based on systemic, age-related biomarkers. We included studies that investigated differences between persons with schizophrenia and healthy comparison subjects in levels of biomarkers known to be associated with aging and examined the relationship of these biomarkers to age in the 2 groups. Results: Forty-two articles that met our selection criteria were reviewed. Nearly 75% reported abnormal biomarker levels among individuals with schizophrenia, including indices of inflammation, cytotoxicity, oxidative stress, metabolic health, gene expression, and receptor/synaptic function, with medium to large effect sizes reported in many studies. Twenty-nine percent of the studies observed differential age-related decline in schizophrenia. Markers of receptor/synaptic function and gene expression were most frequently differentially related to age in schizophrenia. Schizophrenia patients with greater disease severity and longer illness duration exhibited higher levels of inflammatory and oxidative stress biomarkers and shorter telomere length. Conclusions: Most studies show biomarker abnormalities in schizophrenia, and there is some suggestion for accelerated aging. Although definitive interpretation is limited by cross-sectional design of the published reports, findings in the area of gene expression and synaptic function are promising and pave the way for future longitudinal studies needed to fully test this hypothesis.

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“…Even if medical problems are identified, medical in-patients with mental illness appear to experience more post-operative complications and elevated mortality (Copeland 2008;Khaykin 2010). Yet it is the nature as well as the extent of comorbid physical illnesses that is concerning, with an excess of metabolic and cardiovascular problems (Mitchell 2006;Leucht 2007;Bresee 2010). The European METEOR study reported that 70% of patients receiving antipsychotics for schizophrenia had lipid disorders and 40% hypertension (De Hert 2008), and a more recent US study found that 90% of Medicaid recipients prescribed second-generation antipsychotics for schizophrenia had at least one major metabolic risk factor (Bell 2009).…”

Section: Articlementioning

confidence: 99%

Let's get physical: improving the medical care of people with severe mental illness

Mitchell¹,

Delaffon²,

Lord³

2012

Adv. psychiatr. treat

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SummaryThere is clear evidence of increased medical comorbidity and related mortality in people with severe mental illness, despite numerous guidelines for managing medical conditions in this population. This article assesses inequalities in medical treatment and preventive healthcare received by psychiatric patients compared with the general population. It considers whether the medical care provided is adequate and whether published guidelines improve it. Mental health specialists, general practitioners and hospital specialists appear to deliver poorer than average medical care for this vulnerable population. Implementation of physical healthcare guidelines is incomplete and the guidelines must be matched with resources to address this deficit.

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Physical health and schizophrenia

Cited by 88 publications

References 53 publications

A pilot study to assess attitudes, behaviors, and inter‐office communication by psychiatrists and primary care providers in the care of older adults with schizophrenia

A pilot study to assess attitudes, behaviors, and inter‐office communication by psychiatrists and primary care providers in the care of older adults with schizophrenia

Systemic Biomarkers of Accelerated Aging in Schizophrenia: A Critical Review and Future Directions

Let's get physical: improving the medical care of people with severe mental illness

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