Physical Function and Disability in Older Adults with Diabetes

Rekeneire, Nathalie de; Volpato, Stefano

doi:10.1016/j.cger.2014.08.018

Cited by 42 publications

(23 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our results confirmed a significant and independent effect of CV diseases, hypertension, diabetes mellitus, hip fracture, malignancy, mental illness, and neurologic disorders on walking difficulty (21,23,(39)(40)(41)(42)(43)(44). However, the effects of these conditions were relatively small after controlling for OA, BMI, and PVD.…”

supporting

confidence: 68%

Impact of Osteoarthritis on Difficulty Walking: A Population‐Based Study

King

Kendzerska

Waugh

et al. 2017

Arthritis Care & Research

View full text Add to dashboard Cite

Objective. To assess the relationship of hip and knee osteoarthritis (OA) to walking difficulty. Methods. A population cohort ages ≤55 years recruited from 1996 to 1998 (n = 28,451) completed a standardized questionnaire assessing demographics, health conditions, joint symptoms, and functional limitations, including difficulty walking in the past 3 months. Survey data were linked to health administrative databases; self-report and administrative data were used to identify health conditions. Hip/knee OA was defined as self-reported swelling, pain, or stiffness in a hip or knee lasting ≥6 weeks in the past 3 months without an inflammatory arthritis diagnosis. Using multivariable logistic regression, we examined the determinants of walking difficulty and constructed a clinical nomogram. Results. A total of 18,490 cohort participants were eligible (mean age 68 years, 60% women), and 25% reported difficulty walking. Difficulty walking was significantly and independently associated with older age, female sex, body mass index, and several health conditions. Of the conditions examined, the likelihood of walking difficulty was greatest with hip and knee OA and increased with the number of hip/knee joints affected. The predicted probability of difficulty walking for a 60-year-old middle-income, normal-weight woman was 5-10% with no health conditions, 10-20% with diabetes mellitus and cardiovascular (CV) disease, 40% with OA in 2 hips/knees, 60-70% with diabetes mellitus, CV disease, and OA in 2 hips/knees, and 80% with diabetes mellitus, CV disease, and OA in all hips/knees. Conclusion. In a population cohort, symptomatic hip/knee OA was the strongest contributor to walking difficulty. Given the importance of walking to engagement in physical activity for chronic disease management, greater attention to OA is warranted.

show abstract

supporting

confidence: 68%

Impact of Osteoarthritis on Difficulty Walking: A Population‐Based Study

King

Kendzerska

Waugh

et al. 2017

Arthritis Care & Research

View full text Add to dashboard Cite

show abstract

“…Thus, the disabling impact from the diseases among younger elders appears to carry more weight, while other factors besides the reported diseases contribute to the prevalence of disability during aging, leading to the observation of higher background values among the oldest old. Although chronic diseases are consistently associated with disability 5,6,7,8,9,10,11,12,13,30,31,32 , other factors are also determinant in this event, such as socio-demographic conditions and health behaviors 33,34 , which were not examined in detail in this study, but which are present in the background. One can thus suggest that the other factors show an uneven distribution between the age brackets, being more common among older seniors and exerting greater influence on prevalence of disability in this age group, contrary to the chronic diseases analyzed in the study.…”

Section: Discussionmentioning

confidence: 91%

“…Meanwhile, diabetes only showed a significant contribution to limitations in BADL, in both sexes. Like arthritis and stroke, diabetes may involve impairment of neuromuscular functions, in addition to sensory (visual) and circulatory functions 13 , especially at more advanced ages, in which it is assumed that time with the disease is longer and consequently entails more (and more serious) sequelae 13,42 . Such sequelae can thus lead to greater impact on the performance of basic activities of daily living, as observed in an Italian study 43 , reinforcing the importance of this disease in more severe disability.…”

Section: Discussionmentioning

confidence: 99%

“…Various studies have shown an association between functional decline and presence of one or more chronic diseases in the elderly 5,6,7,8,9,10,11,12,13 . The diseases most commonly associated with functional decline are cardiovascular disease, lung disease, hypertension, diabetes, and joint disease, which have a greater effect on functionality.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Contribution of chronic diseases to the prevalence of disability in basic and instrumental activities of daily living in elderly Brazilians: the National Health Survey (2013)

et al. 2018

View full text Add to dashboard Cite

This study's objective was to assess the contribution of selected chronic diseases to the prevalence of disability in elderly Brazilians, based on data from the National Health Survey (PNS 2013). Disability was defined as some degree of difficulty in performing ten activities, considering three levels: (i) without disability; (ii) disabled only in some instrumental activity of daily living (IADL); and (iii) disabled in some basic activity of daily living (BADL). The multinomial additive hazards model was the attribution method used to assess the contribution of each self-reported chronic condition (hypertension, diabetes, arthritis, stroke, depression, heart disease, and lung disease) to the prevalence of disability in this population, stratified by sex and age bracket (60 to 74 years and 75 or older). Study participants included 10,537 elderly Brazilians with a mean age of 70.0 years (SD = 7.9 years) and predominance of women (57.4%). Prevalence rates for disability in at least one IADL and at least one BADL were 14% (95%CI: 12.9; 15.1) and 14.9% (95%CI: 13.8; 16.1), respectively. In general, the contribution of chronic diseases to prevalence of disability was greater in younger elderly (60 to 74 years) and in the group with greatest severity (disabled in BADL), highlighting the relevance of stroke and arthritis in men, and arthritis, hypertension, and diabetes in women. This knowledge can help orient health services to target specific groups, considering age, sex, and current illnesses, aimed at preventing disability in the elderly.

show abstract

“…Persons with diabetes have an increased risk of functional limitations with up to 70% of patients having difficulty with routine physical tasks. 35,36 Thus, the favorable body composition changes observed in our study may have implications in ultimately reducing the burden of disability in persons with diabetes and this needs to be investigated in future studies.…”

Section: Discussionmentioning

confidence: 87%

The relationship of fasting hyperglycemia to changes in fat and muscle mass after exercise training in type 2 diabetes

Yalamanchi

Stewart

et al. 2016

Diabetes Research and Clinical Practice

View full text Add to dashboard Cite

Aims Exercise training (ET) has been variably associated with body composition changes among persons with type 2 diabetes (T2DM). The degree to which these changes are related to hyperglycemia remains unclear. Our objective was to investigate the relationship of baseline fasting glucose (FG) to the magnitude of muscle gains and fat loss after ET in individuals with T2DM. Methods Participants were enrolled in the SHAPE-2 trial, a six month supervised aerobic and resistance training intervention (three days/week), at Johns Hopkins. This was a post-hoc single arm intervention study of participants who completed the exercise intervention (n=50). Participants were aged 40-65 years and had T2DM that was not treated with insulin. Body composition was assessed by DEXA. Results After 6 months of ET, total fat mass decreased (−2.1 ± 3.1 kg) and total lean body mass (LBM) increased (0.5 ± 2.0 kg) overall, but there was variability among individual participants. There was an increase in % total LBM (1.4 ± 1.9%) and decrease in % total body fat mass (−1.5±2.0%) after ET. Interestingly, each standard deviation (SD) increase in baseline FG (mean=135.5 mg/dl; SD= 39.0 mg/dl) was related to a significant increase in % total LBM (0.54±0.26%, p=0.048) and decrease in % total body fat (−0.57±0.27%, p=0.04) after ET among individual participants. Conclusions Our data demonstrate that muscle gains and fat loss after ET are positively related to baseline hyperglycemia. Further studies are needed to characterize differences in metabolic response following ET among persons with diabetes.

show abstract

Physical Function and Disability in Older Adults with Diabetes

Cited by 42 publications

References 72 publications

Impact of Osteoarthritis on Difficulty Walking: A Population‐Based Study

Impact of Osteoarthritis on Difficulty Walking: A Population‐Based Study

Contribution of chronic diseases to the prevalence of disability in basic and instrumental activities of daily living in elderly Brazilians: the National Health Survey (2013)

The relationship of fasting hyperglycemia to changes in fat and muscle mass after exercise training in type 2 diabetes

Contact Info

Product

Resources

About