Physical function after dietary weight loss in overweight and obese adults with osteoarthritis: a systematic review and meta-analysis

Webb, Emily; Osmotherly, Peter G.; Baines, Susan

doi:10.1017/s1368980020002529

Cited by 7 publications

(11 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, semaglutide, which had the greatest effect on weight loss within this analysis, resulted in the greatest improvement in IWQOL‐Lite physical function scores and one of the strongest effects on SF‐36 scores. Results of a 2020 study investigating the effects of a dietary intervention on physical function showed that meal replacement or very low‐energy diets were more effective than any other lifestyle programs for improving physical function 10 . Therefore, it is likely that improvements in self‐reported physical function are proportional to the amount of weight lost.…”

Section: Discussionmentioning

confidence: 99%

“…A reduction in biomechanical loading resulting from weight loss can enhance an individual's ability to undertake everyday tasks of living with improved physical functioning. This is consistently observed particularly after dietary‐induced or surgically induced weight loss interventions 8–10 . Epidemiological research has also suggested a bi‐directional relationship between weight change and activity, where reduced body weight may contribute to increasing physical activity levels 11,12 .…”

Section: Introductionmentioning

confidence: 92%

“…Results of a 2020 study investigating the effects of a dietary intervention on physical function showed that meal replacement or very low-energy diets were more effective than any other lifestyle programs for improving physical function. 10 Therefore, it is likely that improvements in self-reported physical function are proportional to the amount of weight lost. However, it is also possible that the mode of weight loss acts as an additional determinant of improved physical function.…”

Section: Self-reported and Objective Physical Functionmentioning

confidence: 99%

See 2 more Smart Citations

The effects of weight‐lowering pharmacotherapies on physical activity, function and fitness: A systematic review and meta‐analysis of randomized controlled trials

et al. 2023

View full text Add to dashboard Cite

Summary Weight‐lowering pharmacotherapies provide an option for weight management; however, their effects on physical activity, function, and cardiorespiratory fitness are not fully understood. We conducted a systematic review and meta‐analysis of randomized controlled trials to investigate the effect of licensed weight loss pharmacotherapies on physical activity, physical function, and cardiorespiratory fitness in individuals with obesity. Fourteen trials met our prespecified inclusion criteria: Five investigated liraglutide, four semaglutide, three naltrexone/bupropion, and two phentermine/topiramate. All 14 trials included a self‐reported measure of physical function, with the pooled findings suggesting an improvement favoring the pharmacotherapy intervention groups (SMD: 0.27; 95% CI: 0.22 to 0.32) and effects generally consistent across different therapies. Results were also consistent when stratified by the two most commonly used measures: The Short‐Form 36‐Item Questionnaire (SF‐36) (0.24; 0.17 to 0.32) and the Impact of Weight on Quality Of Life‐Lite (IWQOL‐Lite) (0.29; 0.23 to 0.35). Meta‐regression confirmed a significant association between pharmacotherapy induced weight loss and improved physical function for IWQOL‐Lite (p = 0.003). None of the studies reported a physical activity outcome, and only one study reported objectively measured cardiorespiratory fitness. Improvements in self‐reported physical function were observed with weight loss therapy, but the effect on physical activity or objectively measured physical function and fitness could not be determined.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 92%

Section: Self-reported and Objective Physical Functionmentioning

confidence: 99%

See 1 more Smart Citation

The effects of weight‐lowering pharmacotherapies on physical activity, function and fitness: A systematic review and meta‐analysis of randomized controlled trials

et al. 2023

View full text Add to dashboard Cite

show abstract

“… 116 It is possible that the improvements in mental well‐being seen at mid‐diet and potentially at post‐diet, may be—in part—a result of these biological shifts. 116 It is also important to note that physical quality of life (e.g., physical functioning) is likely to have improved across participants included in our meta‐analyses, 117 , 118 and that any improvements in physical quality of life may have had indirect effects on mental well‐being.…”

Section: Discussionmentioning

confidence: 99%

Effects of total diet replacement programs on mental well‐being: A systematic review with meta‐analyses

et al. 2022

View full text Add to dashboard Cite

This systematic review with meta-analyses assessed the effects of total diet replacement (TDR) programs on mental well-being in clinical trial participants with a body mass index greater than or equal to 25 kg/m 2 . TDR programs involve replacing all dietary requirements with nutritionally replete formula foods and are generally administered to induce rapid weight loss. To date, it is largely unclear what effects TDR programs may have on mental well-being, particularly in the long-term. To address this, we screened 25,976 references across six databases and extracted 35 publications. These 35 publications provided sufficient data to evaluate the effects of TDR programs on depression, anxiety, stress, positive affect, negative affect, vitality, role-emotional, social functioning, mental health, mental composite summary score, self-esteem, and general psychological health in 24 meta-analyses.Due to the lack of research comparing TDR programs to comparator groups, 22 of our 24 meta-analyses explored change in these mental well-being sub-domains over time in TDR programs without comparators. Specifically, we assessed the change from pre-diet (before the TDR program) to either post-diet (up to and including two months after the TDR program); and/or follow-up (more than two months after the TDR program). For depression and anxiety, we were also able to assess the change from pre-diet to mid-diet (which fell within two weeks of the diet half-way point). The remaining two meta-analyses assessed the difference in depression scores between a TDR group and a food-based comparator group from pre-diet to post-diet and from pre-diet to follow-up. Across all meta-analyses, our results found no marked adverse effects of TDR programs on any mental well-being sub-domain. In fact, clear improvements were observed for depression, anxiety, stress, vitality, role-emotional, and social functioning at post-diet. Interestingly, the improvements for depression, vitality and role-emotional were maintained at follow-up. All improvements were

show abstract

“…While knee OA clinical guidelines recommend weight loss [ 14 , 15 ], they do not specify how best to do this or which dietary approach to use. There is evidence to show that very low calorie diets (VLCDs) involving meal replacements are more effective for inducing significant weight loss and improving physical function than diets that involve lifestyle counselling alone in people with knee OA [ 29 ]. Ketogenic VLCDs, whereby carbohydrate intake is additionally restricted (< 50-60 g per day), have also been demonstrated to be an effective and safe means of achieving rapid weight loss in the adult population with overweight and obesity [ 30 ] and lead to greater weight loss than low-fat diets in the short-term [ 31 ].…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of a telehealth physiotherapist-delivered intensive dietary weight loss program combined with exercise in people with knee osteoarthritis and overweight or obesity: study protocol for the POWER randomized controlled trial

Bennell

Jones

Hinman

et al. 2022

BMC Musculoskelet Disord

View full text Add to dashboard Cite

Background Obesity is associated with knee osteoarthritis (OA). Weight loss, alongside exercise, is a recommended treatment for individuals with knee OA and overweight/obesity. However, many patients cannot access weight loss specialists such as dietitians. Innovative care models expanding roles of other clinicians may increase access to weight loss support for people with knee OA. Physiotherapists may be well placed to deliver such support. This two-group parallel, superiority randomized controlled trial aims to compare a physiotherapist-delivered diet and exercise program to an exercise program alone, over 6 months. The primary hypothesis is that the physiotherapist-delivered diet plus exercise program will lead to greater weight loss than the exercise program. Methods 88 participants with painful knee OA and body mass index (BMI) > 27 kg/m2 will be recruited from the community. Following baseline assessment, participants will be randomised to either exercise alone or diet plus exercise groups. Participants in the exercise group will have 6 consultations (20–30 min) via videoconference with a physiotherapist over 6 months for a strengthening exercise program, physical activity plan and educational/exercise resources. Participants in the diet plus exercise group will have 6 consultations (50–75 min) via videoconference with a physiotherapist prescribing a ketogenic very low-calorie diet with meal replacements and educational resources to support weight loss and healthy eating, plus the intervention of the exercise only group. Outcomes are measured at baseline and 6 months. The primary outcome is percentage change in body weight measured by a blinded assessor. Secondary outcomes include self-reported knee pain, physical function, global change in knee problems, quality of life, physical activity levels, and internalised weight stigma, as well as BMI, waist circumference, waist-to-hip ratio, physical performance measures and quadriceps strength, measured by a blinded assessor. Additional measures include adherence, adverse events, fidelity and process measures. Discussion This trial will determine whether a physiotherapist-delivered diet plus exercise program is more effective for weight loss than an exercise only program. Findings will inform the development and implementation of innovative health service models addressing weight management and exercise for patients with knee OA and overweight/obesity. Trial registration NIH US National Library of Medicine, Clinicaltrials.gov NCT04733053 (Feb 1 2021).

show abstract

Physical function after dietary weight loss in overweight and obese adults with osteoarthritis: a systematic review and meta-analysis

Cited by 7 publications

References 38 publications

The effects of weight‐lowering pharmacotherapies on physical activity, function and fitness: A systematic review and meta‐analysis of randomized controlled trials

The effects of weight‐lowering pharmacotherapies on physical activity, function and fitness: A systematic review and meta‐analysis of randomized controlled trials

Effects of total diet replacement programs on mental well‐being: A systematic review with meta‐analyses

Effectiveness of a telehealth physiotherapist-delivered intensive dietary weight loss program combined with exercise in people with knee osteoarthritis and overweight or obesity: study protocol for the POWER randomized controlled trial

Contact Info

Product

Resources

About