Physical Factors in the Pathogenesis of Atheroma Formation

Four-Dimensional Ultrasonographic Characterization of Plaque Surface Motion in Patients With Symptomatic and Asymptomatic Carotid Artery Stenosis

“…This notion is derived from experimental work providing evidence that variable vessel wall distensibilities, geometric asymmetries at branching sites, and blood flow disturbances play key roles as localizing factors for atherosclerosis, presumably reflecting the response of the residential vessel wall to moving blood particles, pulsatile pressure, and tension changes from the adjacent flow field. 2,3 This dynamic interaction between plaque geometry and its local hemodynamic environment may be instrumental in plaque modeling and in conditions leading to plaque instability. In particular, heterogeneous plaques would be expected to display different elastic properties that may or may not allow local plaque deformations, depending on the extent and location of calcifications, fibrous matrix, lipid deposits, and intraplaque hemorrhages.…”

A Study on Prevalence of Carotid Artery Stenosis in Acute Ischaemic Stroke Patients

“…6,7,8 Carotid atherosclerosis will lead to plaque formation and these plaques slowly increase in size and cause significant stenosis. 9,10 Atherosclerotic plaques disrupt the endothelium and then produce ulcer as the endothelium is breached, platelets adhere to the vessel wall and a haemostatic plug is formed. This platelet nidus initiates the coagulation cascade and thrombus is formed which occludes the vessel lumen.…”