Physical exercise training interventions for children and young adults during and after treatment for childhood cancer

Braam, Katja I.; Torre, Patrick van der; Takken, Tim; Veening, Margreet A.; Broeder, Eline van Dulmen‐den; Kaspers, Gertjan J. L.

doi:10.1002/14651858.cd008796.pub2

Cited by 132 publications

(180 citation statements)

References 37 publications

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“…A meta-analysis study has examined the effect of physical exercise programs for children with cancer. 47 Other investigators have examined the interest of growth hormone supplementation in a select population of patients. 48,49 A group of American investigators has shown that preventive therapeutic interventions limiting the increase in BMI and insulin resistance may be particularly important during maintenance therapy.…”

Section: Number Of Cases (%) 95% CImentioning

confidence: 99%

Metabolic syndrome in long-term survivors of childhood acute leukemia treated without hematopoietic stem cell transplantation: an L.E.A. study

et al. 2016

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C ardiovascular conditions are serious long-term complications of childhood acute leukemia. However, few studies have investigated the risk of metabolic syndrome, a known predictor of cardiovascular disease, in patients treated without hematopoietic stem cell transplantation. We describe the overall and age-specific prevalence, and the risk factors for metabolic syndrome and its components in the L.E.A. (Leucémie de l'Enfant et de l'Adolescent) French cohort of childhood acute leukemia survivors treated without hematopoietic stem cell transplantation. The study included 650 adult patients (mean age at evaluation: 24.2 years; mean follow-up after leukemia diagnosis: 16.0 years). The prevalence of metabolic syndrome was 6.9% (95% CI 5.1-9.2). The age-specific cumulative prevalence at 20, 25, 30 and 35 years of age was 1.3%, 6.1%, 10.8% and 22.4%, respectively. The prevalence of decreased high-density lipoprotein cholesterol, increased triglycerides, increased fasting glucose, increased blood pressure and increased abdominal circumference was 26.8%, 11.7%, 5.8%, 36.7% and 16.7%, respectively. Risk factors significantly associated with metabolic syndrome in the multivariate analysis were male sex (OR 2.64; 95% CI 1.32-5.29), age at last evaluation (OR 1.10; 95% CI 1.04-1.17) and body mass index at diagnosis (OR 1.15; 95% CI 1.01-1.32). The cumulative steroid dose was not a significant risk factor. Irradiated and non-irradiated patients exhibited different patterns of metabolic abnormalities, with more frequent abdominal obesity in irradiated patients and more frequent hypertension in non-irradiated patients. Survivors of childhood acute leukemia are at risk of metabolic syndrome, even when treated without hematopoietic stem cell transplantation or central nervous system irradiation. A preventive approach with regular screening for cardiovascular risk factors is recommended.

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Section: Number Of Cases (%) 95% CImentioning

confidence: 99%

Metabolic syndrome in long-term survivors of childhood acute leukemia treated without hematopoietic stem cell transplantation: an L.E.A. study

et al. 2016

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“…Additionally, ankle dorsiflexion with goniometers has been measured in children to assess lower limb extremity extensibility for proper foot mechanics [39].…”

Section: Motor and Skill Assessmentmentioning

confidence: 99%

“…Braam et al provide the most current review of childhood and young adult cancer exercise training interventions during and after cancer [39]. In general, children need a minimal level of physical fitness for normal growth and development [50].…”

Section: Guidelines For Exercise Prescription In Pediatric Cancer Patmentioning

confidence: 99%

“…As a result of the numerous LAE related to pediatric cancer treatment, an interest in using exercise as a therapeutic measure to attenuate or reverse many cancer-related LAE in the pediatric population has surfaced. While comparatively less studied, the research suggests that there is a positive effect of physical activity on organ system function, fatigue, and physical well-being in children during and after cancer treatment [39][40][41][42][43][44][45][46][47][48][49]. It is clear that children who exercise can increase aerobic fitness and strength, with the latter a result of neuromuscular adaptations rather than skeletal muscle hypertrophy.…”

Section: Introductionmentioning

confidence: 99%

“…In adults, it appears that the most effective strategies for increasing physical activity levels after treatment are individualized programs that are initiated under supervision and are later adopted into life-style behaviors in an unsupervised setting [38,51]. It is not clear whether this is an ideal strategy for childhood cancer patients, but it appears that most current pediatric cancer exercise programs implement this approach [39,40].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Role of Exercise in Pediatric and Adolescent Cancers: A Review of Assessments and Suggestions for Clinical Implementation

Klika

Tamburini

Galanti

et al. 2018

JFMK

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Abstract:In the European Union, five-year survival rates for childhood cancer patients are approaching 72-80%, which is a testament to better diagnostics and improved treatment. As a result, a large proportion of childhood cancer patients go on to live productive lives well past reproductive age. While this is encouraging, childhood cancer treatment is accompanied by multiple long-term adverse effects on physical and mental wellbeing. While there are several approaches to address mental health, reproductive integrity, secondary pathologies, and recurrence, in order to optimize quality of life in childhood cancer patients, exercise and nutrition should also be considered. It is clear that physical activity plays an important role in the prevention and reduction of long-term adverse side effects associated with cancer treatment in both children and adults. However, the current exercise guidelines for cancer survivors are based on adult data and accordingly are not appropriate for children. As children and adults are markedly different, including both the pathophysiology of cancer and exercise response, treatment plans incorporating exercise for children should be age-specific and individually tailored to both reduce the development of future comorbidities and enhance physical health. The purpose of this paper is to review the predominant cancer types and effects of cancer treatment in children, describe several special considerations, and propose a framework for assessment and exercise guidelines for this population.

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Exercise and Well-being in Adult Survivors of Childhood Cancer—Time for Interventions

Mack

2020

JAMA Oncol

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Physical exercise training interventions for children and young adults during and after treatment for childhood cancer

Abstract: Physical exercise training interventions for children and young adults during and after treatment for childhood cancer.

Cited by 132 publications

References 37 publications

Metabolic syndrome in long-term survivors of childhood acute leukemia treated without hematopoietic stem cell transplantation: an L.E.A. study

Metabolic syndrome in long-term survivors of childhood acute leukemia treated without hematopoietic stem cell transplantation: an L.E.A. study

The Role of Exercise in Pediatric and Adolescent Cancers: A Review of Assessments and Suggestions for Clinical Implementation

Exercise and Well-being in Adult Survivors of Childhood Cancer—Time for Interventions

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