Physical exercise reduces synthesis of ADMA SDMA and L-Arg

Riccioni, Graziano

doi:10.2741/e739

Cited by 22 publications

(12 citation statements)

References 33 publications

(14 reference statements)

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“…As ADMA functions as an inhibitor of nitric oxide synthase, high plasma ADMA levels are considered as a cardiovascular risk factor [59] and an increased urinary excretion seems to be one of the main mechanisms lowering ADMA plasma levels [60]. Recently, it was shown that physical exercise decreases ADMA levels in plasma [61]. However, the effect of exercise on urinary ADMA excretion in healthy individuals has rarely been examined so far.…”

Section: Discussionmentioning

confidence: 99%

High-Intensity Interval Training Decreases Resting Urinary Hypoxanthine Concentration in Young Active Men—A Metabolomic Approach

et al. 2019

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High-intensity interval training (HIIT) is known to improve performance and skeletal muscle energy metabolism. However, whether the body’s adaptation to an exhausting short-term HIIT is reflected in the resting human metabolome has not been examined so far. Therefore, a randomized controlled intervention study was performed to investigate the effect of a ten-day HIIT on the resting urinary metabolome of young active men. Fasting spot urine was collected before (−1 day) and after (+1 day; +4 days) the training intervention and 65 urinary metabolites were identified by liquid chromatography-mass spectrometry (LC-MS) and nuclear magnetic resonance (NMR) spectroscopy. Metabolite concentrations were normalized to urinary creatinine and subjected to univariate statistical analysis. One day after HIIT, no overall change in resting urinary metabolome, except a significant difference with decreasing means in urinary hypoxanthine concentration, was documented in the experimental group. As hypoxanthine is related to purine degradation, lower resting urinary hypoxanthine levels may indicate a training-induced adaptation in purine nucleotide metabolism.

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Section: Discussionmentioning

confidence: 99%

High-Intensity Interval Training Decreases Resting Urinary Hypoxanthine Concentration in Young Active Men—A Metabolomic Approach

et al. 2019

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“…Additionally, arginine is a glucogenic amino acid that contributes to gluconeogenesis. Prolonged and strenuous exercise decreases asymmetric dimethylarginine (ADMA) [31], one of the substrates for citrulline synthesis.…”

Section: Amino Acids Arginine Metabolism-and Urea Cycle Related-metamentioning

confidence: 99%

Metabolite Shifts Induced by Marathon Race Competition Differ between Athletes Based on Level of Fitness and Performance: A Substudy of the Enzy-MagIC Study

et al. 2020

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This study compared metabolite shifts induced by training for, participation in, and recovery from a marathon race competition among athletes divided into three groups based on fitness (relative maximum oxygen uptake (VO2max)) and performance levels (net running time). Plasma samples from 76 male runners participating in the Munich Marathon were analyzed for metabolite shifts using a targeted metabolomics panel. For the entire cohort of runners, pronounced increases were measured immediately after the race for plasma concentrations of acylcarnitines (AC), the ratio (palmitoylcarnitine + stearoylcarnitine)/free carnitine that is used as a proxy for the activity of the mitochondrial enzyme carnitine palmitoyltransferase, and arginine-related metabolites, with decreases in most amino acids (AA) and phospholipids. Plasma levels of AA and phospholipids were strongly increased 24 and 72 h post-race. Post-race plasma concentrations of AC and arginine-related metabolites were higher in the low compared to top performers, indicating an accumulation of fatty acids and a reliance on protein catabolism to provide energy after the marathon event. This study showed that marathon race competition is associated with an extensive and prolonged perturbation in plasma metabolite concentrations with a strong AC signature that is greater in the slower, less aerobically fit runners. Furthermore, changes in the arginine-related metabolites were observed.

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“…ADMA is an inhibitor of NO synthase (NOS) and a key enzyme for NO production [52,53,54,55]. SDMA is indirectly inhibiting NOS [13,17,55]. NO is the most potent vasorelaxant agent [17,56,57,58] with strong anti-atherogenic, anti-inflammatory and anti-thrombotic action [17,55,58].…”

Section: Discussionmentioning

confidence: 99%

“…SDMA is indirectly inhibiting NOS [13,17,55]. NO is the most potent vasorelaxant agent [17,56,57,58] with strong anti-atherogenic, anti-inflammatory and anti-thrombotic action [17,55,58]. Eighty percent of ADMA is degraded by dimethylarginine dimethylamonohydrolase (DDAH), enzyme which is very active in kidney and liver [13,59], and 20% of ADMA in excreted by kidneys [17,52].…”

Section: Discussionmentioning

confidence: 99%

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Changes in Water Soluble Uremic Toxins and Urinary Acute Kidney Injury Biomarkers After 10- and 100-km Runs

Wołyniec

Kasprowicz

Giebułtowicz

et al. 2019

IJERPH

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Acute kidney injury (AKI) is described as a relatively common complication of exercise. In clinical practice the diagnosis of AKI is based on serum creatinine, the level of which is dependent not only on glomerular filtration rate but also on muscle mass and injury. Therefore, the diagnosis of AKI is overestimated after physical exercise. The aim of this study was to determine changes in uremic toxins: creatinine, urea, uric acid, asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), trimethylamine N-oxide (TMAO) and urinary makers of AKI: albumin, neutrophil gelatinase-associated lipocalin (uNGAL), kidney injury molecule-1 and cystatin-C (uCyst-C) after long runs. Sixteen runners, mean age 36.7 ± 8.2 years, (2 women, 14 men) participating in 10- and 100-km races were studied. Blood and urine were taken before and after the races to assess markers of AKI. A statistically significant increase in creatinine, urea, uric acid, SDMA and all studied urinary AKI markers was observed. TMAO and ADMA levels did not change. The changes in studied markers seem to be a physiological reaction, because they were observed almost in every runner. The diagnosis of kidney failure after exercise is challenging. The most valuable novel markers which can help in post-exercise AKI diagnosis are uCyst-C and uNGAL.

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Physical exercise reduces synthesis of ADMA SDMA and L-Arg

Cited by 22 publications

References 33 publications

High-Intensity Interval Training Decreases Resting Urinary Hypoxanthine Concentration in Young Active Men—A Metabolomic Approach

High-Intensity Interval Training Decreases Resting Urinary Hypoxanthine Concentration in Young Active Men—A Metabolomic Approach

Metabolite Shifts Induced by Marathon Race Competition Differ between Athletes Based on Level of Fitness and Performance: A Substudy of the Enzy-MagIC Study

Changes in Water Soluble Uremic Toxins and Urinary Acute Kidney Injury Biomarkers After 10- and 100-km Runs

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