Physical exercise prevents short and long-term deficits on aversive and recognition memory and attenuates brain oxidative damage induced by maternal deprivation

Neves, Ben-Hur Souto das; Menezes, Jefferson; Souza, Mauren Assis; Mello‐Carpes, Pâmela Billig

doi:10.1016/j.physbeh.2015.09.019

Cited by 27 publications

(14 citation statements)

References 63 publications

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“…Our data demonstrate that maternal exercise rescued the cognitive deficits caused by repeated prenatal exposure to sevoflurane. This finding is consistent with previous studies, which showed that maternal physical activity attenuated postnatal memory deficits induced by maternal deprivation (Neves et al, 2015 ), mild chronic postnatal hypoxia (Akhavan et al, 2012 ) or hyperthermia-induced neuronal apoptosis (Lee et al, 2011 ) and in rat pups born to lipopolysaccharide-exposed dams or to maternal rats with hypothyroidism (Kim et al, 2015 ; Shafiee et al, 2016 ). In the present study, we found that maternal treadmill exercise was able to induce hippocampal histone acetylation at H3K14 and H3K27 in the pups.…”

Section: Discussionsupporting

confidence: 92%

Effects of Sevoflurane Exposure During Mid-Pregnancy on Learning and Memory in Offspring Rats: Beneficial Effects of Maternal Exercise

Zhang

et al. 2018

Front. Cell. Neurosci.

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Fetal exposure to general anesthetics may pose significant neurocognitive risks but methods to mitigate against these detrimental effects are still to be determined. We set out, therefore, to assess whether single or repeated in utero exposure to sevoflurane triggers long-term cognitive impairments in rat offspring. Since maternal exercise during pregnancy has been shown to improve cognition in offspring, we hypothesized that maternal treadmill exercise during pregnancy would protect against sevoflurane-induced neurotoxicity. In the first experiment, pregnant rats were exposed to 3% sevoflurane for 2 h on gestational (G) day 14, or to sequential exposure for 2 h on G13, G14 and G15. In the second experiment, pregnant rats in the exercise group were forced to run on a treadmill for 60 min/day during the whole pregnancy. The TrkB antagonist ANA-12 was used to investigate whether the brain-derived neurotrophic factor (BDNF)/TrkB/Akt signaling pathway is involved in the neuroprotection afforded by maternal exercise. Our data suggest that repeated, but not single, exposure to sevoflurane caused a reduction in both histone acetylation and BDNF expression in fetal brain tissues and postnatal hippocampus. This was accompanied by decreased numbers of dendritic spines, impaired spatial-dependent learning and memory dysfunction. These effects were mitigated by maternal exercise but the TrkB antagonist ANA-12 abolished the beneficial effects of maternal exercise. Our findings suggest that repeated, but not single, exposure to sevoflurane in pregnant rats during the second trimester caused long-lasting learning and memory dysfunction in the offspring. Maternal exercise ameliorated the postnatal neurocognitive impairment by enhancing histone acetylation and activating downstream BDNF/TrkB/Akt signaling.

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Section: Discussionsupporting

confidence: 92%

Effects of Sevoflurane Exposure During Mid-Pregnancy on Learning and Memory in Offspring Rats: Beneficial Effects of Maternal Exercise

Zhang

et al. 2018

Front. Cell. Neurosci.

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“…This finding is further supported by previous work showing that after a protocol of exercise, mice showed increased performance in memory task, specifically SOR (Ferreira‐Vieira et al, ). Also, these observations are in line with the findings of Neves et al () (Neves, Menezes, Souza, & Mello‐Carpes, ) who showed recognition deficits after maternal deprivation and that exercise reversed these effects.…”

Section: Discussionsupporting

confidence: 92%

“…Data are presented as mean ± SEM WEARICK-SILVA ET AL. | 271 Mello-Carpes, 2015) who showed recognition deficits after maternal deprivation and that exercise reversed these effects.…”

Section: Discussionmentioning

confidence: 99%

Running during adolescence rescues a maternal separation‐induced memory impairment in female mice: Potential role of differential exon‐specific BDNF expression

Wearick-Silva

Marshall

Viola

et al. 2016

Developmental Psychobiology

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Exposure to early life stress has been associated with memory impairments related to changes in brain-derived neurotrophic factor (BDNF) signaling. However, the potential impact of physical exercise to reverse these effects of maternal separation has been under investigated. Mice were subjected to maternal separation during the first 2 weeks of life and then exposed to a 3-week running protocol during adolescence. The spontaneous object recognition task was performed during adolescence followed by analysis of hippocampal expression of exons I, IV, and IX of the BDNF gene. As expected, maternal separation impaired recognition memory and this effect was reversed by exercise. In addition, running increased BDNF exon I expression, but decreased expression of BDNF exon IV in all groups, while exon IX expression increased only in MS animals exposed to exercise. Our data suggest that memory deficits can be attenuated by exercise and specific transcripts of the BDNF gene are dynamically regulated following both MS and exercise.

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“…Maternal deprivation is one of the most compelling natural stressors during the early stages of development (Neves et al, 2015;Uysal et al, 2005). Events from this type of stress can result in permanent deficits during adulthood (Neves et al, 2015). (Markovic et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Cortico-hippocampal morphology and behavioural indices improved in maternal deprivation model of schizophrenia following vitamin B complex supplementation

Omotoso

Abdulsalam

Mutholib

et al. 2020

Preprint

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Maternal deprivation (MD) during early life development has been documented to culminate in long-term alterations in brain function and behavioural manifestations that mimic schizophrenia. This study elucidated the putative neuroprotective roles of vitamin B complex in MD-induced behavioural and neurochemical modifications in hippocampus and prefrontal cortex of Wistar rats. Rat pups were maternally deprived on postnatal day 9 for 24 hours and then treated with or without vitamin B complex for 15 days while a control group was undisturbed during the experimental period. The rats were then subjected to behavioural paradigms to measure memory indices and anxiety levels. The rats were sacrificed to obtain the PFC and hippocampus for histomorphological and biochemical analysis. Behavioural analysis of the animals revealed that MD induced a declination in long-and short-term memory in addition to anxiety-like behaviour in the open field test. Cortico-hippocampal histomorphology of these animals showed an increased astrocytic density and chromatolysis, which were accompanied by reduced levels of superoxide dismutase and catalase enzymes.Vitamin B complex mitigated MD-induced behavioural decline, histomorphological perturbation and oxidative stress by enhancing the intrinsic antioxidant defence, thereby culminating in nootropic behaviour and reduced anxiety. In conclusion, we confirmed the hypothesis that vitamin B complex is neuroprotective against neuropathological alterations induced by maternal deprivation.

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Physical exercise prevents short and long-term deficits on aversive and recognition memory and attenuates brain oxidative damage induced by maternal deprivation

Cited by 27 publications

References 63 publications

Effects of Sevoflurane Exposure During Mid-Pregnancy on Learning and Memory in Offspring Rats: Beneficial Effects of Maternal Exercise

Effects of Sevoflurane Exposure During Mid-Pregnancy on Learning and Memory in Offspring Rats: Beneficial Effects of Maternal Exercise

Running during adolescence rescues a maternal separation‐induced memory impairment in female mice: Potential role of differential exon‐specific BDNF expression

Cortico-hippocampal morphology and behavioural indices improved in maternal deprivation model of schizophrenia following vitamin B complex supplementation

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