Physical exercise influences astrocytes in the striatum of a Parkinson’s disease male mouse model

Vitorino, Louise Caroline; Oliveira, Karla Ferreira; Silva, Wagner Antonio Barbosa da; Gomes, Carlos Augusto Borges de Andrade; Romão, Luciana; Allodi, Silvana; Corrêa, Clynton Lourenço

doi:10.1016/j.neulet.2022.136466

Cited by 1 publication

(1 citation statement)

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“…Treadmill exercise was found to reduce Ibal-1 expression, TNF-α and IL-1β levels in MPTP mice, and to suppress the TLR2/MyD88/NF-κB signaling pathway, reducing motor deficits and the decline in dopamine levels [70]. In 6-OHDAinduced Parkinsonism, the morphology of striatal astrocytes and GFAP levels returned to normal to some degree after exercise [71]. The 6-OHDA PD mice showed increased activation of astrocytes, microglia, and oxidative species before exercise, and exercise prevented the neuroinflammatory response [72].…”

Section: Exercise Modulation Of Glial Molecular Mechanismsmentioning

confidence: 99%

Molecular mechanisms of glial cells in brain disorders following physical exercise

Liu,

Ran,

et al. 2023

Stress and Brain

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Physical exercise generally improves health in humans and animals and may enhance cognitive function and neural function in the brain, especially in the prefrontal cortex and hippocampus. It is also a promising intervention for brain disorders such as psychiatric conditions and neurodegenerative diseases. The neuroprotective mechanisms of exercise are related to synaptic plasticity, neurogenesis, and autophagy. Moreover, the therapeutic effects of exercise are associated with glial cell function in the brain. In this review, we examine the relationship between glial cell function and brain disorders. We also consider the role of glial cells in modulating the effects of exercise on the molecular mechanisms and neural circuits involved in central and peripheral brain function. This review demonstrates that glial cells may play an important role in the effects of physical exercise interventions on the brain, particularly in those with neurological disorders.

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Section: Exercise Modulation Of Glial Molecular Mechanismsmentioning

confidence: 99%