Physical Exercise-Induced FGF-21 to Fight Obesity: An Update Review

Vecchiatto, Bruno; Castro, Thiago Lucas de; Muller, Cynthia R.; Azevedo-Martins, Anna Karenina; Evangelista, Fabiana S.

doi:10.3390/obesities2040031

Cited by 2 publications

(2 citation statements)

References 62 publications

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“…By health condition: elderly; conflict, diabetes; increased, fatty liver; conflict. Based on previous studies, FGF-21 mainly showed an increase in aerobic exercise and endurance exercise, which is consistent with a clearer result as the age is younger and thinner [ 44 , 45 ]. It was decreased in resistance exercise, but other previous studies showed conflicting results.…”

Section: Discussionsupporting

confidence: 82%

Exercise-Induced Fibroblast Growth Factor-21: A Systematic Review and Meta-Analysis

Kim

Jung

Park

et al. 2023

IJMS

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This systematic review aimed to synthesize and quantify the results of the studies investigating the changes in fibroblast growth factor-21 (FGF-21) induced by exercise. We searched for studies that did not differentiate between patients and healthy adults but compared them before and after exercise and with and without exercise. For quality assessment, the risk-of-bias assessment tool for nonrandomized studies and the Cochrane risk-of-bias tool were used. A quantitative analysis was performed using the standardized mean difference (SMD) and random-effects model in RevMan 5.4. A total of 94 studies were searched in international electronic databases, and after screening, 10 studies with 376 participants were analyzed. Compared with no exercise, there was a significant increase in the FGF-21 levels from before to after exercise (SMD = 1.05, 95% confidence interval (CI), 0.21 to 1.89). The changes in FGF-21 levels in the exercise group showed a significant difference from the levels in the controls. The results of the random-effects model were as follows: SMD = 1.12; 95% CI, −0.13 to 2.37. While the data on acute exercise were not synthesized in this study, FGF-21 levels generally increased after chronic exercise compared with no exercise.

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Section: Discussionsupporting

confidence: 82%

Exercise-Induced Fibroblast Growth Factor-21: A Systematic Review and Meta-Analysis

Kim

Jung

Park

et al. 2023

IJMS

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“…Although plasma FGF21 levels have been described as biomarkers of metabolic disorders or mitochondrial myopathies (67-69), its release from muscle has been associated with improvements in metabolic function (42,70,71). Consequently, it is complex to assign a favorable or harmful role to the circulating levels of FGF21 "per se" for metabolic health.…”

Section: Discussionmentioning

confidence: 99%

Fibroblast growth factor 21 is expressed and secreted from skeletal muscle following electrical stimulation via extracellular ATP activation of the PI3K/Akt/mTOR signaling pathway

Arias‐Calderón

Casas²,

Balanta‐Melo³

et al. 2023

Front. Endocrinol.

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Fibroblast growth factor 21 (FGF21) is a hormone involved in the regulation of lipid, glucose, and energy metabolism. Although it is released mainly from the liver, in recent years it has been shown that it is a “myokine”, synthesized in skeletal muscles after exercise and stress conditions through an Akt-dependent pathway and secreted for mediating autocrine and endocrine roles. To date, the molecular mechanism for the pathophysiological regulation of FGF21 production in skeletal muscle is not totally understood. We have previously demonstrated that muscle membrane depolarization controls gene expression through extracellular ATP (eATP) signaling, by a mechanism defined as “Excitation-Transcription coupling”. eATP signaling regulates the expression and secretion of interleukin 6, a well-defined myokine, and activates the Akt/mTOR signaling pathway. This work aimed to study the effect of electrical stimulation in the regulation of both production and secretion of skeletal muscle FGF21, through eATP signaling and PI3K/Akt pathway. Our results show that electrical stimulation increases both mRNA and protein (intracellular and secreted) levels of FGF21, dependent on an extracellular ATP signaling mechanism in skeletal muscle. Using pharmacological inhibitors, we demonstrated that FGF21 production and secretion from muscle requires the activation of the P2YR/PI3K/Akt/mTOR signaling pathway. These results confirm skeletal muscle as a source of FGF21 in physiological conditions and unveil a new molecular mechanism for regulating FGF21 production in this tissue. Our results will allow to identify new molecular targets to understand the regulation of FGF21 both in physiological and pathological conditions, such as exercise, aging, insulin resistance, and Duchenne muscular dystrophy, all characterized by an alteration in both FGF21 levels and ATP signaling components. These data reinforce that eATP signaling is a relevant mechanism for myokine expression in skeletal muscle.

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Physical Exercise-Induced FGF-21 to Fight Obesity: An Update Review

Cited by 2 publications

References 62 publications

Exercise-Induced Fibroblast Growth Factor-21: A Systematic Review and Meta-Analysis

Exercise-Induced Fibroblast Growth Factor-21: A Systematic Review and Meta-Analysis

Fibroblast growth factor 21 is expressed and secreted from skeletal muscle following electrical stimulation via extracellular ATP activation of the PI3K/Akt/mTOR signaling pathway

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