Physical exercise improves quality of life, depressive symptoms, and cognition across chronic brain disorders: a transdiagnostic systematic review and meta-analysis of randomized controlled trials

Dauwan, Meenakshi; Begemann, Marieke J H; Slot, Margot I. E.; H, Lee; Scheltens, Philip; Sommer, Iris

doi:10.1007/s00415-019-09493-9

Cited by 146 publications

(113 citation statements)

References 237 publications

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“…MET is an index of energy expenditure that results from IPAQ‐SF, a commonly used questionnaire to assess quantitatively physical activity, even in PD 8,10 . A higher rate of physical activity improves quality of life, mood, and cognitive performances, and even motor disturbances in PD patients, exerting beneficial effects either at brain or systemic level 8,11,12 . The reduction of such “protective” action might thus explain the perception of worsening in these patients, which also presented a greater burden of PD‐related disturbances (PWBM score) and depressive symptoms (BDI score) compared to those referring stable conditions.…”

Section: Discussionmentioning

confidence: 99%

Physical Activity Changes and Correlate Effects in Patients with Parkinson's Disease during COVID‐19 Lockdown

Schirinzi

Lazzaro

Salimei

et al. 2020

Movement Disord Clin Pract

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Background Background: COVID-19 outbreak profoundly affected health systems and people's daily life worldwide. Parkinson's disease (PD) patients lost their normal routine and interrupted regular physical activity, either as physiotherapy or sport, with inevitable consequence on their daily-life and well-being. Objectives Objectives: To evaluate the changes in physical activity due to COVID-19 emergency, including self-management strategies or technology-assisted activities, and the subsequent clinical implications in PD patients. Methods Methods: Seventy-four patients from an Italian center have been remotely examined during the lockdown (April-May 2020) by an e-mail structured survey, including self-administered scales. We collected and analyzed data on changes, modalities and amount of physical active practice, on the use of technology-based tools, and on self-perceived clinical condition. Results Results: Sixty percent of patients reported a significant worsening of their general conditions during the lockdown, the reduction of physical activity being the main risk factor for such change. However, patients found ways to practice physical activity, using satisfactorily technology assistance in 50% of cases (mostly women). Conclusions Conclusions: The COVID-19 emergency has been an ordeal for PD patients. Nevertheless, patients adapted their habits to continue practicing physical activity that resulted a main determinant of their well-being; as well, they successfully approached technology-based assistance. Education, communication, and networking emerge as critical for a constructive reaction to the emergency's challenges.

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Section: Discussionmentioning

confidence: 99%

Physical Activity Changes and Correlate Effects in Patients with Parkinson's Disease during COVID‐19 Lockdown

Schirinzi

Lazzaro

Salimei

et al. 2020

Movement Disord Clin Pract

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“…Rather different physical exercise interventions had all positive clinical effects in patients with schizophrenia, unipolar depression, Alzheimer's disease, Huntington's disease, Parkinson's disease, and multiple sclerosis. 90 Many professionals state that the prescription of physical activity interventions should be placed on a par with drug prescription, but this implies that neuropsychiatrists "know how to prescribe, monitor, and evaluate the effectiveness of the exercise prescribed". 91 However, this is not often the case and this obstacle must be overcome by the multidisciplinary approach with the support of the exercise trainer.…”

Section: Practical Suggestions To Promote Physical Activitymentioning

confidence: 99%

<p>Healthy Eating, Physical Activity, and Sleep Hygiene (HEPAS) as the Winning Triad for Sustaining Physical and Mental Health in Patients at Risk for or with Neuropsychiatric Disorders: Considerations for Clinical Practice</p>

Briguglio¹,

Vitale²,

Galentino³

et al. 2020

NDT

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Neuropsychiatric disorders stem from gene-environment interaction and their development can be, at least in some cases, prevented by the adoption of healthy and protective lifestyles. Once full blown, neuropsychiatric disorders are prevalent conditions that patients live with a great burden of disability. Indeed, the determinants that increase the affliction of neuropsychiatric disorders are various, with unhealthy lifestyles providing a significant contribution in the interplay between genetic, epigenetic, and environmental factors that ultimately represent the pathophysiological basis of these impairing conditions. On one hand, the adoption of Healthy Eating education, Physical Activity programs, and Sleep hygiene promotion (HEPAS) has the potential to become one of the most suitable interventions to reduce the risk to develop neuropsychiatric disorders, while, on the other hand, its integration with pharmacological and psychological therapies seems to be essential in the overall management of neuropsychiatric disorders in order to reduce the disability and improve the quality of life of affected patients. We present an overview of the current evidence in relation to HEPAS components in the prevention and management of neuropsychiatric disorders and provide suggestions for clinical practice.

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“…The role of physical activity in improving the QoL has been demonstrated in various diseases. Recently, a meta-analysis conducted in six chronic brain disorders (Parkinson's disease, Alzheimer's disease, Huntington's disease, multiple sclerosis, schizophrenia, and unipolar depression) confirmed that exercise is superior to pharmacological treatment in improving QoL (Dauwan et al, 2019). The maintenance of QoL found in this study in individuals with ALS who exercised, and the tendency toward lower values of QoL in individuals with ALS who did not exercise, is probably due to the fact that participants in the TRAIN group felt that their motor skills were maintained and that they could do something about it.…”

Section: Discussionmentioning

confidence: 99%

Tailored Exercise Training Counteracts Muscle Disuse and Attenuates Reductions in Physical Function in Individuals With Amyotrophic Lateral Sclerosis

et al. 2019

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Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease, characterized by the progressive loss of motor neurons, which leads to a reduction in strength and exercise capacity. Although the concept of "Exercise is Medicine" is accepted for many diseases, the role of exercise in individuals with ALS is still debated. The aim of this study was to propose a tailored exercise training program that was both safe and effective for individuals with ALS, and to evaluate the effects of this combined, moderateintensity, aerobic and strength training program on aerobic capacities, strength, and physical function. Sixteen individuals with ALS were randomly assigned to either a training (three times a week for 12 weeks; TRAIN, n = 8) or usual care (continued their usual standard of care and served as control; UC, n = 8) group. Peak power, peak oxygen uptake, as well as the gas exchange threshold (GET) during a cardiopulmonary exercise test (CPET) on a cycle ergometer, and the maximal strength (1RM) of the knee extensor muscles, were evaluated before and after 12 weeks. Participants also performed the "Timed Up and Go" (TUG) and the "6-min walking" (6MWT) tests. The ALS Functional Rating Scale revisited (ALSFRS-R), the ALS Severity Scale (ALS-SS), and the McGill quality of life (QoL) questionnaire were also measured. The GET increased from 0.94 ± 0.08 to 1.06 ± 0.10 L min −1 in TRAIN (p = 0.009) and decreased from 0.79 ± 0.17 to 0.72 ± 0.17 L min −1 in UC (p = 0.001). There was a significant difference between groups for changes in TUG (9.1 ± 5.5% improvement in TRAIN and 56.8 ± 18.5% worsening in UC, p = 0.002), ALSFRS-R (4.7 ± 2.6% decrease in TRAIN and 23.0 ± 5.6% decrease in UC, p = 0.007), and for the ALS-SS (2.2 ± 2.1% decrease in TRAIN and 12.4 ± 4.4% decrease in UC, p = 0.04). Even if the 1RM of the knee-extensor muscles showed a tendency to increase in TRAIN (70.1 ± 30.0%, p = 0.07), there was not a statistically significant difference (p = 0.57) with respect to the

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Physical exercise improves quality of life, depressive symptoms, and cognition across chronic brain disorders: a transdiagnostic systematic review and meta-analysis of randomized controlled trials

Cited by 146 publications

References 237 publications

Physical Activity Changes and Correlate Effects in Patients with Parkinson's Disease during COVID‐19 Lockdown

Physical Activity Changes and Correlate Effects in Patients with Parkinson's Disease during COVID‐19 Lockdown

<p>Healthy Eating, Physical Activity, and Sleep Hygiene (HEPAS) as the Winning Triad for Sustaining Physical and Mental Health in Patients at Risk for or with Neuropsychiatric Disorders: Considerations for Clinical Practice</p>

Tailored Exercise Training Counteracts Muscle Disuse and Attenuates Reductions in Physical Function in Individuals With Amyotrophic Lateral Sclerosis

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