Physical exercise elicits UPRmt in the skeletal muscle: The role of c-Jun N-terminal kinase

Gaspar, Rodrigo Stellzer; Katashima, Carlos Kiyoshi; Crisol, Barbara Moreira; Carneiro, Fernanda Silva; Sampaio, Igor; Silveira, Leonardo dos Reis; Silva, Adelino Sanchez Ramos da; Cintra, Dennys Esper; Pauli, José Rodrigo; Ropelle, Eduardo Rochete

doi:10.1016/j.molmet.2023.101816

Cited by 1 publication

(1 citation statement)

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“…128 In aged nonobese mice, aerobic exercise also affects UPR mt in skeletal muscle by increasing Hsp60, Lonp1, and Yme1l1 on gastrocnemius, which were decreased by aging. 129 Similar to the aging animal model, elderly subjects with low UPR mt -related genes in the skeletal muscle presented low levels of OXPHOS-related genes; conversely, elderly individuals with higher levels of UPR mt -related genes displayed a consistent increase in several mitochondrial genes, including in OXPHOS. Interestingly, high-intensity exercise increased Lonp1, ClpP, and Yme1l1 protein content in aged mice muscle.…”

Section: Upr M T In Muscular Tissuementioning

confidence: 92%

Tissue‐specific roles of mitochondrial unfolded protein response during obesity

Carneiro,

Katashima,

Dodge

et al. 2024

Obesity Reviews

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Obesity is a worldwide multifactorial disease caused by an imbalance in energy metabolism, increasing adiposity, weight gain, and promoting related diseases such as diabetes, cardiovascular diseases, neurodegeneration, and cancer. Recent findings have reported that metabolic stress related to obesity induces a mitochondrial stress response called mitochondrial unfolded protein response (UPRmt), a quality control pathway that occurs in a nuclear DNA–mitochondria crosstalk, causing transduction of chaperones and proteases under stress conditions. The duality of UPRmt signaling, with both beneficial and detrimental effects, acts in different contexts depending on the tissue, cell type, and physiological states, affecting the mitochondrial function and efficiency and the metabolism homeostasis during obesity, which remains not fully clarified. Therefore, this review discusses the most recent findings regarding UPRmt signaling during obesity, bringing an overview of UPRmt across different metabolic tissues.

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Section: Upr M T In Muscular Tissuementioning

confidence: 92%