Physical Exercise and Neuroinflammation in Major Depressive Disorder

Ignácio, Zuleide Maria; Silva, Renato S da; Plissari, Marcos Eduardo; Quevedo, Joao L De; Réus, Gislaine Z.

doi:10.1007/s12035-019-01670-1

Cited by 98 publications

(51 citation statements)

References 126 publications

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“…The putative anti-inflammatory properties of exercise can partially be explained by reduced visceral adiposity, as adipose tissue is an important source of systemic inflammation [121]. Some studies have suggested that physical activity increases gene expression of PGC-1-α (peroxisome proliferator-activated receptor C coactivator-1α) [122], a transcription coactivator that plays a central role in the regulation of cellular energy metabolism [123]. PGC-1-α is a coactivator of transcription factors with neuroprotective properties and controls gene expression of pro-inflammatory cytokines in muscles, partly by inhibition of the NF-KB pathway [116,124] (11,8).…”

Section: Is Exercise Efficacious In Inflammatory Depression?mentioning

confidence: 99%

Inflammatory Depression—Mechanisms and Non-Pharmacological Interventions

Suneson

Lindahl

Hårsmar

et al. 2021

IJMS

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Treatment of depression is hampered by the failure to identify distinct symptom profiles with distinct pathophysiologies that differentially respond to distinct treatments. We posit that inflammatory depression is a meaningful depression subtype associated with specific symptoms and biological abnormalities. We review several upstream, potentially causative, mechanisms driving low-grade inflammation in this subtype of depression. We also discuss downstream mechanisms mediating the link between inflammation and symptoms of depression, including alterations in dopaminergic neurotransmission and tryptophan metabolism. Finally, we review evidence for several non-pharmacological interventions for inflammatory depression, including probiotics, omega-3 fatty acids, and physical exercise interventions. While some evidence suggests that these interventions may be efficacious in inflammatory depression, future clinical trials should consider enriching patient populations for inflammatory markers, or stratify patients by inflammatory status, to confirm or refute this hypothesis.

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Section: Is Exercise Efficacious In Inflammatory Depression?mentioning

confidence: 99%

Inflammatory Depression—Mechanisms and Non-Pharmacological Interventions

Suneson

Lindahl

Hårsmar

et al. 2021

IJMS

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“…Drugs may lose their efficiency over time if they work at all [4]. Also, major depressive disorder (MDD) is "a prevalent psychiatric disorder associated with various prognosis, chronic course, and duration of illness with decreased quality of life" [8]. A study was conducted by [9] found that "the prevalence of depressive symptoms was 28.6% and that of depressive disorders was 11.3%."…”

Section: Significance Of the Studymentioning

confidence: 99%

The Effectiveness of Mindfulness Training Techniques on Stress, Anxiety, and Depression of Depressed Patient

Atia¹,

Sallam²

2019

AJNR

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Depression remains one of the world's most urgent health problems, affecting an estimated 350 million people. Mindfulness is effective for people suffering from critical depressive symptoms. The aim of this study was to evaluate the effectiveness of mindfulness training techniques on stress, anxiety, and depression of depressed patients. Design: -Quasi-experimental design (one group pretest-posttest design) was used to achieve the aim of the study. Setting: -The study was conducted at the Psychiatric Hospital in Tanta and The Psychiatric and Addiction Treatment Hospital in Met-Khalf, Menoufia governorate, Egypt. Sample: -A Purposive sample (34) depressed patients that were diagnosed by psychiatrists according to DSM5 were selected; in the chosen setting inpatient clinics. Tools: Data were collected using the depression, anxiety and stress scale. Results: The results revealed that there is a highly statistically significant reduction in stress, anxiety, and depression mean score level among the study group after mindfulness training techniques than before; where p-value (p = 0.001). Also, there is a statistically significant positive correlation between stress and depression level of study group before and after mindfulness training techniques where p-value (p = 0.015, 0.013), respectively. Conclusion: The implementation of mindfulness training techniques with depressed patients has a positive effect on reducing stress, anxiety, and depression levels. Recommendation: Application of mindfulness training techniques for all patients with depression to reduce their stress, anxiety, and depression levels.

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“…Inflammatory mediators released by immune cells, such as TNFα, IL-1β, IL-6, PGE 2 , and PGI 2 , result in pain sensitization [ 28 ]. Exercise and physical therapy alleviate chronic neuropathic pain by modulating neuroinflammation [ 29 , 30 , 31 , 32 , 33 ]. Irisin has also been suggested to alleviate pain sensitization [ 34 , 35 ] and possess diagnostic value for pain symptoms [ 36 , 37 ].…”

Section: Introductionmentioning

confidence: 99%

Irisin Gene Delivery Ameliorates Burn-Induced Sensory and Motor Neuropathy

Huang

Yang

et al. 2020

IJMS

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Burn-related neuropathy is common and often involves pain, paresthesia, or muscle weakness. Irisin, an exercise-induced myokine after cleavage from its membrane precursor fibronectin type III domain-containing 5 (FNDC5), exhibits neuroprotective and anti-inflammatory activities. A rat model of third-degree burn on the right hind paw was used to investigate the therapeutic role of irisin/FNDC5. Rats received burn injury and were treated with intrathecal recombinant adenovirus containing the irisin sequence (Ad-irisin) at 3 weeks postburn. One week later, mechanical allodynia was examined. The expression of irisin in cerebrospinal fluid (CSF) was detected. Ipsilateral gastrocnemius muscle and lumbar spinal cord were also obtained for further investigation. Furthermore, the anti-apoptotic effect of recombinant irisin in SH-SY5Y cells was evaluated through tumor necrosis factor alpha (TNFα) stimulus to mimic burn injury. We noted intrathecal Ad-irisin attenuated pain sensitization and gastrocnemius muscle atrophy by modulating the level of irisin in CSF, and the expression of neuronal FNDC5/irisin and TNFα in the spinal cord. Ad-irisin also ameliorated neuronal apoptosis in both dorsal and ventral horns. Furthermore, recombinant irisin attenuated TNFα-induced SH-SY5Y cell apoptosis. In summary, irisin attenuated allodynia and muscle wasting by ameliorating neuroinflammation-induced neuronal apoptosis.

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Physical Exercise and Neuroinflammation in Major Depressive Disorder

Cited by 98 publications

References 126 publications

Inflammatory Depression—Mechanisms and Non-Pharmacological Interventions

Inflammatory Depression—Mechanisms and Non-Pharmacological Interventions

The Effectiveness of Mindfulness Training Techniques on Stress, Anxiety, and Depression of Depressed Patient

Irisin Gene Delivery Ameliorates Burn-Induced Sensory and Motor Neuropathy

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