Physical Exercise and Health: A Focus on Its Protective Role in Neurodegenerative Diseases

Bonanni, Roberto; Cariati, Ida; Tarantino, Umberto; D’Arcangelo, Giovanna; Tancredi, Virginia

doi:10.3390/jfmk7020038

Cited by 37 publications

(28 citation statements)

References 113 publications

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“…In particular, improved cognitive function has been suggested to depend upon increased production of neurotrophins, known mediators of neuronal development, survival, and function [ 76 ]. In this context, brain-derived neurotrophic factor (BDNF) appears to be the most susceptible to exercise-induced regulation and may be among the main contributors to the cascade of molecular and cellular events that support brain plasticity.…”

Section: Molecular Mediators Involved In Wbv Effectsmentioning

confidence: 99%

Whole Body Vibration: A Valid Alternative Strategy to Exercise?

Bonanni

Cariati

Romagnoli

et al. 2022

JFMK

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Several studies agree that mechanical vibration can induce physiological changes at different levels, improving neuromuscular function through postural control strategies, muscle tuning mechanisms and tonic vibration reflexes. Whole-body vibration has also been reported to increase bone mineral density and muscle mass and strength, as well as to relieve pain and modulate proprioceptive function in patients with osteoarthritis or lower back pain. Furthermore, vibratory training was found to be an effective strategy for improving the physical performance of healthy athletes in terms of muscle strength, agility, flexibility, and vertical jump height. Notably, several benefits have also been observed at the brain level, proving to be an important factor in protecting and/or preventing the development of age-related cognitive disorders. Although research in this field is still debated, certain molecular mechanisms responsible for the response to whole-body vibration also appear to be involved in physiological adaptations to exercise, suggesting the possibility of using it as an alternative or reinforcing strategy to canonical training. Understanding these mechanisms is crucial for the development of whole body vibration protocols appropriately designed based on individual needs to optimize these effects. Therefore, we performed a narrative review of the literature, consulting the bibliographic databases MEDLINE and Google Scholar, to i) summarize the most recent scientific evidence on the effects of whole-body vibration and the molecular mechanisms proposed so far to provide a useful state of the art and ii) assess the potential of whole-body vibration as a form of passive training in place of or in association with exercise.

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Section: Molecular Mediators Involved In Wbv Effectsmentioning

confidence: 99%

Whole Body Vibration: A Valid Alternative Strategy to Exercise?

Bonanni

Cariati

Romagnoli

et al. 2022

JFMK

Self Cite

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“…89 Undoubtedly, prevention is fundamental and represents a goal that, if achieved, makes it possible not only to improve individuals' quality of life but also to reduce the socioeconomic and health costs associated with such a widespread disease. 90 The osteosarcopenia development can be prevented by acting on modifiable risk factors. Indeed, a healthy lifestyle and regular exercise are currently the first-line choices for the prevention and treatment of osteosarcopenia (Table 1).…”

Section: Possible Prevention and Treatment Strategiesmentioning

confidence: 99%

Osteosarcopenia and Long-COVID: a dangerous combination

Tarantino

Visconti

Bonanni

et al. 2022

Therapeutic Advances in Musculoskeletal

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SARS-CoV-2 has caused a global pandemic and an unprecedented public health crisis, infecting more than 580 million people worldwide. Moreover, recent evidence has suggested the emergence of a new syndrome known as Long-COVID, a term used to describe a diverse set of physical and mental symptoms that persist after a diagnosed SARS-CoV-2 infection. Epidemiological data have identified myalgias, muscle and joint dysfunction, and bone fragility as common sequelae in patients with moderate and severe forms of this disease. Significant musculoskeletal dysfunction has also been detected in some healed patients, although knowledge about pathophysiological mechanisms of Long-COVID is still rather scarce. In this context, SARS-CoV-2 infection has been suggested to amplify the effects of aging on the musculoskeletal system by aggravating the osteosarcopenic state. Based on this evidence, our review focused on the muscle and bone tissue alterations induced by SARS-CoV-2 infection and Long-COVID, summarizing the current knowledge on the underlying biological mechanisms and highlighting the need for a multidisciplinary approach to predict the musculoskeletal targets and long-term consequences of COVID-19 disease.

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“…The skeletal muscle is an endocrine organ capable of secreting a variety of neurotrophic factors with neuroprotective and beneficial effects [ 124 ]. For example, neurological disorders, impaired cognition, dementia, and depression are associated with lower levels of circulating brain-derived neurotrophic factor (BDNF), which can be mitigated by exercise [ 125 ].…”

Section: Ameliorating Mitochondrial Dysfunction In Parkinson’s Diseas...mentioning

confidence: 99%

Exercise-Boosted Mitochondrial Remodeling in Parkinson’s Disease

et al. 2022

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Parkinson’s disease (PD) is a movement disorder characterized by the progressive degeneration of dopaminergic neurons resulting in dopamine deficiency in the striatum. Given the estimated escalation in the number of people with PD in the coming decades, interventions aimed at minimizing morbidity and improving quality of life are crucial. Mitochondrial dysfunction and oxidative stress are intrinsic factors related to PD pathogenesis. Accumulating evidence suggests that patients with PD might benefit from various forms of exercise in diverse ways, from general health improvements to disease-specific effects and, potentially, disease-modifying effects. However, the signaling and mechanism connecting skeletal muscle-increased activity and brain remodeling are poorly elucidated. In this review, we describe skeletal muscle–brain crosstalk in PD, with a special focus on mitochondrial effects, proposing mitochondrial dysfunction as a linker in the muscle–brain axis in this neurodegenerative disease and as a promising therapeutic target. Moreover, we outline how exercise secretome can improve mitochondrial health and impact the nervous system to slow down PD progression. Understanding the regulation of the mitochondrial function by exercise in PD may be beneficial in defining interventions to delay the onset of this neurodegenerative disease.

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Physical Exercise and Health: A Focus on Its Protective Role in Neurodegenerative Diseases

Cited by 37 publications

References 113 publications

Whole Body Vibration: A Valid Alternative Strategy to Exercise?

Whole Body Vibration: A Valid Alternative Strategy to Exercise?

Osteosarcopenia and Long-COVID: a dangerous combination

Exercise-Boosted Mitochondrial Remodeling in Parkinson’s Disease

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