Physical evaluations of Haruan spray for wound dressing and wound healing.

Abstract

Haruan spray (aerosol) dosage form is a new dosage form formulated for use as wound dressing and wound healing. Spray can minimize pain and emotional trauma experience during the application and removal process of conventional dressing and bandages. Haruan extract is incorporated as an active ingredient of the aerosol concentrate for its ability to enhance the healing process. The aim of this study is to evaluate the physical properties of Haruan spray using different propellant. The propellants evaluated were 1,1,1,2 -tetrafluoroethane (HFA 134a), butane and propane. Concentrate of aerosol also contain hydroxypropyl methylcellulose (HPMC) as polymer and glycerine as plasticizer. All ingredients of the aerosol were packaged in an aluminium container fitted with continuous-spray valves. Evaluations for the Haruan spray included delivery rate, delivery amount, pressure, minimum fill, leakage, flammability, spray patterns and particles image. Glass containers were used to study incompatibility between the concentrate and propellant due to the ease of visible inspection. HFA 134a reacted with the concentrate and produced white aggregates, while propane had a very high vapour pressure. From safety and economics point of view, butane was chosen as the propellant because it met the requirements for aerosol and produced Haruan spray with the expected characteristics.

Channa striata (Ikan Gabus) Extract and the Acceleration of Tuberculosis Treatment: A True Experimental Study

“…The cream formulation of Channa striata extract can heal the wound in Sprague-Dawley rats (250-300 g) [28]. Besides, the Channa striata is also formulated in spray form to heal the wound [29, 30]. The aerosol form is created from butane, propene, and the combination of butane-propene as propellant [30].…”

“…Besides, the Channa striata is also formulated in spray form to heal the wound [29, 30]. The aerosol form is created from butane, propene, and the combination of butane-propene as propellant [30]. Furthermore, Maj Jais [31] noted that the extract of Channa striata without bone is unable to decrease the blood sugar and HDL (High Density Lipoprotein) level toward Sprague-Dawley rat and mice.…”

Formulation of Eel (Monopterus albus) extract membranes for wound dressing using plasticizers

“…PVA was dissolved in hot distilled water. Eel extract, methylparaben, propylparaben were dispersed in glycerol, propylene glycol or PEG 400, and then mixed with PVA solution using Ultra turrax at 10,000 rpm for 15 minutes [4,16,17]. The formulae can be seen in Table 1.…”

Formulation of Eel (Monopterus Albus) Extract Gels for Accelerated the Wound Healing

“…HPMC was prepared by cold mechanical method (Febriyenti, et al, 2014;Shivhare, et al, 2009;USP, 2007). Eel extract, methylparaben, propylparaben, and vitamin E were dispersed in propylene glycol and then mixed with the gelling agent using Ultra turrax at 10,000 rpm for 15 min (Febriyenti, et al, 2014;Febriyenti, et al, 2011;Febriyenti, et al, 2008).…”