Physical Compatibility and Chemical Stability of Cisplatin in Various Diluents and in Large-Volume Parenteral Solutions

Mariani, Elio P.; Southard, Bruce J.; Woolever, John T.; Erlich, Ronald H.; Granatek, A.P.

doi:10.1016/b978-0-12-565050-2.50023-1

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High Pressure Liquid Chromatography1

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1992

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“…Mariani et al [156] and later Cheung et al [157] reported a straightphase system for the determination of the stability properties of cisplatin in infusion fluids. Both reversed-phase [120 123] and straight-phase [118 119 121 122] can be used for chromatographic separation of Pt(DDTC) 2 (DDTC: diethyldithiocarbamate) in chloroform.…”

Section: High Pressure Liquid Chromatographymentioning

confidence: 99%

Platinum antitumour agents: A review of (bio)analysis

Hodes

Underberg

Los

et al. 1992

Pharmaceutisch Weekblad Scientific Edition

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This paper summarizes analytical techniques in order to get a clear picture of the ins and outs of the (bio)analysis of platinum-containing compounds. The antitumour agent cisplatin has become an indispensable drug for the cure of a variety of cancer diseases. Since its introduction in the early seventies, about 2,000 related platinum complexes were designed to devoid the dose-limiting nephrotoxicity. Some of them were introduced for clinical trial, such as carboplatin and iproplatin. To investigate the mechanism of action and pharmaco-kinetic behaviour, several interesting assays for total and specific platinum determination in biological matrices have been developed, each with its own possibilities and limitations.

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Section: High Pressure Liquid Chromatographymentioning

confidence: 99%