Physical-Chemical Characterization and Polymorphism Determination of Two Nimodipine Samples Deriving from Distinct Laboratories

Cardoso, Thiago Mota; Rodrigues, Patrik Oening; Stulzer, Hellen Karine; Silva, Marcos Antônio Segatto; Matos, Jivaldo do Rosário

doi:10.1080/03639040500216212

Cited by 22 publications

(10 citation statements)

References 13 publications

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“…The variation of samples reflections is small being larger in the relative intensity. Studies have been considering that the similarity of patterns is established if the scattering angles of the strongest reflections obtained from an sample agree to about 0.2 degrees with that of the reference material; and if the relative intensities of these reflections do not vary more than 20% 2,5 . The d-distance that considers the distance among the crystal plans is similar between carbonates, however, the values of the egg shell calcium carbonate is slightly smaller.…”

Section: Resultsmentioning

confidence: 99%

Physicochemical study of CaCO3 from egg shells

Murakami¹,

Rodrigues²,

Campos³

et al. 2007

Ciênc. Tecnol. Aliment.

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157

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Calcium carbonate, a pharmaceutical excipient, is widely used as diluent in solid dosage forms. It is also used as a base for medicinal and dental preparations, a buffering and dissolution aid for dispersible tablets, a food additive and a calcium supplement. Egg shells are a rich source of mineral salts, mainly calcium carbonate, which corresponds to about 94% of the shell. Layer farms produce large amounts of shells, whose final disposal poses a challenge from the environmental standpoint. This work was designed to evaluate the physicochemical and thermal properties of calcium carbonate obtained from egg shells. The findings indicated that calcium carbonate from egg shells can be used as an alternative pharmaceutical excipient. Keywords: thermal analysis; X-ray powder diffraction; egg shells; calcium carbonate. ResumoO carbonato de cálcio é um excipiente farmacêutico amplamente utilizado como diluente em formas farmacêuticas sólidas. Também é utilizado para auxiliar na dissolução de comprimidos dispersíveis, como base para preparações dentais e medicinais, e como aditivos em suplementos alimentares. A casca de ovo é rica em sais minerais, principalmente o carbonato de cálcio que corresponde a 94% da casca. As indústrias de ovos produzem grande quantidade de casca e seu destino final é um desafio em termos ambientais. Este trabalho teve como objetivo avaliar as propriedades físico-químicas do carbonato de cálcio obtido a partir da casca de ovo. Os resultados demonstraram que o carbonato de cálcio obtido pode ser uma alternativa como excipiente farmacêutico.

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Section: Resultsmentioning

confidence: 99%

Physicochemical study of CaCO3 from egg shells

Murakami¹,

Rodrigues²,

Campos³

et al. 2007

Ciênc. Tecnol. Aliment.

Self Cite

157

View full text Add to dashboard Cite

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“…[11][12][13][14] The substance is a racemic mixture of 2 optical antipodes and shows 2 polymorphic forms. 11 Modi¿ cation I (mod I) is the racemic compound, while modi¿ cation II (mod II) is the conglomerate.…”

Section: Introductionmentioning

confidence: 99%

Characterization of the distribution, polymorphism, and stability of nimodipine in its solid dispersions in polyethylene glycol by micro-Raman spectroscopy and powder x-ray diffraction

Docoslis

Huszarik

Papageorgiou

et al. 2007

AAPS J

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In the present study, a series of solid dispersions of the drug nimodipine using polyethylene glycol as carrier were prepared following the hot-melt method. Micro-Raman spectroscopy in conjunction with X-ray powder diffractometry was used for the characterization of the solid structure, including spatial distribution, physical state, and presence of polymorphs, as well as storage stability of nimodipine in its solid formulations. The effect of storage time on drug stability was investigated by examination of the samples 6 months and 18 months after preparation. Confocal microRaman mapping performed on the samples showed that the drug was not uniformly distributed on a microscopic level. The presence of crystals of nimodipine with sizes varying between one and several micrometers was detected, and the crystal size seemed to increase with overall drug content. In samples examined 6 months after preparation it was found that the crystals existed mainly as the racemic compound, whereas after 18 months of storage mainly crystal conglomerates were observed.

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“…Thermo analytical techniques measure changes in physical or chemical properties of the sample as a function of temperature 3 . Thermo analysis has been used for the rapid evaluation of purity, kinetics decomposition and physical property of drugs 4,5 .…”

Section: Introductionmentioning

confidence: 99%

Untitled

2017

IJPSR

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ABSTRACT:A drug dosage form is very important in delivering the drug in proper dose in most appropriate form. The capsule shell is an excellent barrier to air, and it also has some other advantages such as being easy to swallow and tasteless, flexibility of formulation etc. The use of the hard gelatin capsule dosage form may perhaps be an alternative to overcome the problem, which the hygroscopicity of the extracts may pose. Present study was envisaged to develop a polyherbal formulation as capsule. The results obtained by the thermo analytical techniques showed no chemical incompatibility between capsule shell and herbal extract. The results were further confirmed by IR spectroscopy. The herbal capsule was stored at different temperatures viz., 25 0 C, 40 0 C and 50 0 C for shelf life evaluation. The percentage alkaloid content for day zero was taken as 100% and accordingly, the percentages were calculated for all the other days. The organoleptic properties of the herbal capsule remain unchanged at tested temperatures throughout the stability study. Likewise, pH values were fairly constant and appear not to be influenced by temperature. The herbal capsule showed maximum pharmaceutical elegance and remained stable throughout the observation period. The shelf life of the herbal capsule was found to be 3.2 years which is much more than sufficient to satisfy the regulatory norms of many countries.

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Physical-Chemical Characterization and Polymorphism Determination of Two Nimodipine Samples Deriving from Distinct Laboratories

Cited by 22 publications

References 13 publications

Physicochemical study of CaCO3 from egg shells

Physicochemical study of CaCO3 from egg shells

Characterization of the distribution, polymorphism, and stability of nimodipine in its solid dispersions in polyethylene glycol by micro-Raman spectroscopy and powder x-ray diffraction

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