Physical Characterizations and In Vitro Skin Permeation of Elastic Liposomes for Transdermal Delivery of Polygonum aviculare L. Extract

한샛별,; 권순식,; 정유민,; 공봉주,; 유은령,; 박수남,

doi:10.7317/pk.2014.38.6.694

Cited by 7 publications

(3 citation statements)

References 13 publications

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“…Recent reports describe the preparation of elastic nanoliposomes through the use of nonionic surfactants such as polyglyceryl-3-methylglucose distearate as an edge activator [ 17 , 18 , 19 ]. This surfactant has two alkyl chains, unlike an edge activator with a single alkyl chain that is used in conventional elastic nanoliposomes.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Alkyl Chain Number in Sucrose Surfactant on the Physical Properties of Quercetin-Loaded Deformable Nanoliposome and Its Effect on In Vitro Human Skin Penetration

Hong

Han

et al. 2018

Nanomaterials

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Non-invasive skin penetration of a drug is increased by an edge activator, which enhances the nanoliposome deformability. The objective of this study was to investigate the role of the alkyl chain number of sucrose surfactants as an edge activator in elastic nanoliposomes. In addition, the physicochemical properties of the elastic nanoliposomes were characterized and an in vitro human skin permeation study was performed. Elastic nanoliposomes that were composed of sucrose monostearate (MELQ), sucrose distearate (DELQ), and sucrose tristearte (TELQ) were prepared using a thin-film hydration method. Particle size and entrapment efficiency of elastic nanoliposomes increased proportionally with an increase in the amounts and the numbers of the stearate in sucrose surfactant. Deformability of elastic nanoliposomes was indicated as DELQ > MELQ > TELQ and the same pattern was revealed through the in vitro human skin permeability tests. These results suggest that the number of alkyl chains of sucrose surfactant as edge activator affects the physicochemical property, stability, and skin permeability in elastic nanoliposome. Our findings give a valuable platform for the development of elastic nanoliposomes as skin drug delivery systems.

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Section: Introductionmentioning

confidence: 99%

The Effect of Alkyl Chain Number in Sucrose Surfactant on the Physical Properties of Quercetin-Loaded Deformable Nanoliposome and Its Effect on In Vitro Human Skin Penetration

Hong

Han

et al. 2018

Nanomaterials

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“…제형적 방법에는 리포좀 제형이 있다 (Chung & Han, 2014;Kim et al, 2019). 리포좀은 생체막의 성분인 인지질 을 주성분으로 유효성분을 효율적으로 피부에 침투시킬 수 있는 전달 체로 리포좀 내부의 활성성분을 효과적으로 세포 내로 전달할 수 있 다 (Han et al, 2014;Chung & Han, 2014). 리포좀을 이용한 선행 연구로는 탄성리포좀을 사용하여 소수성 물질인 쿼세틴의 경피 전달 하는 연구 (Park et al, 2012), 비타민 C 유효성분을 독자기술로 리포 좀형태로 만들어서 세포 효능을 평가하는 연구 (Joo et al, 2022) 등 이 있다.…”

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An Experimental Evaluation of Åbsoro-Pep™ on Skin Absorption Using 3D Raman Spectroscopy

Kwon,

Park,

Lee

et al. 2024

Asian J Beauty Cosmetol

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Purpose: The skin acts as a barrier to prevent external harmful substances from entering the body. This function interferes with active ingredient absorption. Understanding the degree of absorption of the substance into the skin is important to predict the effectiveness of cosmetic active ingredients. This study aimed to investigate the human efficacy of Åbsoro-Pep™ substance, which contains gold cysteinyl hydroxy-prolyl dipeptide-48 as a key ingredient, for improving absorption. Methods: This study conducted a human application test to evaluate the improvement in skin absorption (including absorption rate, speed, and depth) of Åbsoro-Pep™ using three-dimensional Raman spectroscopy, targeting adult women aged 20–68 years. Results: The results revealed that skin absorption rate, speed, and depth were all significantly enhanced (p<0.001) 30 min after application of the test substance compared to before application. Additionally, a high-concentration test confirmed that substance A application site was more helpful than substance B application site by improving skin absorption rate, speed, and depth by 1.80, 2.13, and 2.13 times, respectively. Conclusion: Åbsoro-Pep™, which combines gold nanoparticles with peptides, is expected to be predominantly used and applied in functional cosmetics to improve skin absorption.

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“…이와 관련 연구로는 경피 전달을 위한 탄성리포좀의 물리적 특성연 구 (Han et al, 2014), 비타민 C 유효성분을 포함한 리포좀형태 연구 (Joo et al, 2022) (Akdemir et al, 2001). 이미 선행연구를 통해 제라늄의 항 산화, 미백, 항염 효과를 확인한 바 있으며 (Choi, 2022) (Strijkers et al, 2005;Kim et al, 2021).…”

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Whitening and Anti-inflammatory Effects of Geranium maculatum Liposomes

Choi¹

2023

Asian J Beauty Cosmetol

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Purpose: In this study, cytotoxicity and whitening effects of liposomes and non-liposomes containing Geranium maculatum (G. maculatum) were measured to confirm their functionality as a cosmetic material.Methods: The cytotoxicity test was used to measure the effect of G. maculatum in liposomes and non-liposomes on B16F10 cells, and the whitening test was performed to measure the inhibitory effect of G. maculatum in liposomes and non-liposomes on melanin and tyrosinase production. Furthermore, the effect of G. maculatum liposomes on LPS-induced NO production was determined in RAW 264.7 cells. Cell viability was measured using the MTT assay.Results: G. maculatum in liposomes showed higher a cytotoxicity to B16F10 cells than G. maculatum in non-liposomes. Examination of the inhibitory effect on melanin production and tyrosinase production revealed that G. maculatum in liposomes produced a stronger whitening effect than that in non-liposomes. In addition, the experiments using RAW 264.7 cells showed that liposomes containing G. maculatum not only inhibited NO production but also resulted in higher cell viability than non-liposomes containing G. maculatum. Conclusion: Liposomescontaining G. maculatum exert an antiseptic effect through a significant inhibition of NO production. They are preferred as a cosmetic material owing to their inhibitory activity on tyrosinase and melanin production.

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Physical Characterizations and In Vitro Skin Permeation of Elastic Liposomes for Transdermal Delivery of Polygonum aviculare L. Extract

Cited by 7 publications

References 13 publications

The Effect of Alkyl Chain Number in Sucrose Surfactant on the Physical Properties of Quercetin-Loaded Deformable Nanoliposome and Its Effect on In Vitro Human Skin Penetration

The Effect of Alkyl Chain Number in Sucrose Surfactant on the Physical Properties of Quercetin-Loaded Deformable Nanoliposome and Its Effect on In Vitro Human Skin Penetration

An Experimental Evaluation of Åbsoro-Pep™ on Skin Absorption Using 3D Raman Spectroscopy

Whitening and Anti-inflammatory Effects of Geranium maculatum Liposomes

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