Physical Characterization and Dissolution Properties of lbuprofen:Eudragit Coprecipitates

Kislalioglu, M. Serpil; Khan, Mansoor A.; Blount, C.W.; Goettsch, Robert W.; Bolton, Sanford

doi:10.1002/jps.2600800820

Cited by 86 publications

(31 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Bosch and co-workers [31] determined the pK a of ibuprofen in aqueous media through a combination of experiment and computation. Their estimate of 4.5 agrees well with the previous literature values [32][33][34][35]. Since ibuprofen is comigrating with DP7 at pH 6.5, our optimal conditions were anticipated to be found between pH 4.5 and 6.5.…”

Section: Dp7-ibuprofen Interactionssupporting

confidence: 78%

Complexation trends and binding constants between dextrin oligomers and small molecules as measured through affinity capillary electrophoresis

et al. 2003

View full text Add to dashboard Cite

Quantitative aspects of a previously reported pre-equilibration affinity/capillary electrophoretic methodology (Hong, M., et al., Anal. Chem. 1998, 70, 3590-3597) were studied using fluorescently labeled oligosaccharides and analgesic drugs. Frontal analysis capillary electrophoresis (FA-CE) was investigated for these interaction systems. In order to fulfill certain FA requirements, the analysis conditions of the sugar-drug combinations had to be adjusted individually. Only after the establishment of these conditions, acceptable binding data (association constants) could be obtained. The constants are in the range of weak hydrogen bonding and are comparable to the constants that were independently obtained through 1H nuclear magnetic resonance (NMR) spectroscopy.

show abstract

Section: Dp7-ibuprofen Interactionssupporting

confidence: 78%

Complexation trends and binding constants between dextrin oligomers and small molecules as measured through affinity capillary electrophoresis

et al. 2003

View full text Add to dashboard Cite

show abstract

“…Co-precipitation from aqueous acetone was used to prepare microgranule particles of ibuprofen and an S100/E100 mixture [19]. In contrast with the systems based on L100, the combined particles slowed significantly the release rate with a profile comparable to that of a composition based on Zwitter-ionic Eudragit ® (RLPM, RSPM).…”

Section: Co-precipitationmentioning

confidence: 99%

Interpolymer combinations of chemically complementary grades of Eudragit copolymers: a new direction in the design of peroral solid dosage forms of drug delivery systems with controlled release (review)

Mustafin

2011

Pharm Chem J

View full text Add to dashboard Cite

Principles of the combination of chemically complementary grades of Eudragit ® copolymers in peroral, matrix, and reservoir types of solid dosage forms with modified release [tablets, microspheres, (micro)pellets] and their manufacturing technology (including film coatings) are considered. Modified drug release is achieved due to the interaction between reactive groups of copolymer pairs, which controls the drug release process both inside matrices and within multilayers or combined coatings. Analysis of these processes has key significance for developing (meth)acrylate polycomplexes, which could be synthesized in both aqueous and organic media, as new classes of drug carriers for constructing modern peroral drug delivery systems.

show abstract

“…Moreover, solid dispersions (coprecipitates) of different drugs and countercharged poly(meth)acrylates are successfully used in matrix tablets production {RLPO(RSPO)/S100[L100, Eudragit R L 100-55 (L100-55)]}, 8 (E100/S100). 9,10 Microspheres prepared by a solvent evaporation method with the copolymer combinations (RL100/L100-55), 11 [RS100/L100(L100-55)] 12 showed a stronger sustained release.…”

Section: Introductionmentioning

confidence: 99%

Structural Transformations During Swelling of Polycomplex Matrices Based on Countercharged (meth)acrylate Copolymers (EudragitR EPO/EudragitR L 100-55)

Moustafine

Bobyleva

Bukhovets

et al. 2011

Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

Physical Characterization and Dissolution Properties of lbuprofen:Eudragit Coprecipitates

Cited by 86 publications

References 13 publications

Complexation trends and binding constants between dextrin oligomers and small molecules as measured through affinity capillary electrophoresis

Complexation trends and binding constants between dextrin oligomers and small molecules as measured through affinity capillary electrophoresis

Interpolymer combinations of chemically complementary grades of Eudragit copolymers: a new direction in the design of peroral solid dosage forms of drug delivery systems with controlled release (review)

Structural Transformations During Swelling of Polycomplex Matrices Based on Countercharged (meth)acrylate Copolymers (EudragitR EPO/EudragitR L 100-55)

Contact Info

Product

Resources

About